SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff and GRC Chair |
7:45 pm - 9:30 pm | Keynote Presentations: For better or worse |
| Session Chairs / Discussion Leaders: Roger Woodgate (NICHD, NIH, USA) & Nancy Maizels (University of Washington, USA) |
7:45 pm - 8:25 pm | Myron Goodman (University of Southern California, USA) "Better living through hyper-mutation" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Steve Jackson (University of Cambridge, UK) "Detection, signalling and repair of DNA double-strand breaks" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Chair’s opening reception |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Mutagenesis Due to Blocked Replication and Transcription |
| Session Chair / Discussion Leader: Sue Jinks-Robertson (Duke University, USA) |
9:00 am - 9:30 am | Sue Jinks-Robertson (Duke University, USA) "Bypassing roadblocks during DNA replication in yeast" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Robert Fuchs (CNRS, Marseille, France) "Polymerase trafficking at the transiently blocked replication fork" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Julian Sale (MRC Cambridge, UK) "The timing and control of translesion synthesis" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break / Group Photo |
11:05 am - 11:30 am | Graham Walker (MIT, USA) "Dealing with DNA problems: Replication Blocks and Template Lesions" |
11:30am - 11:40 am | Discussion |
11:40 am - 11:55 am | Dmitry Gordenin (NIEHS, NIH, USA) "Damage-induced localized hypermutability" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Andrés Aguilera (Universidad de Sevilla, Spain) "Transcription-associated genomic instability in mRNP biogenesis and export mutants" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Consequences of Oxidative Stress |
| Session Chair / Discussion Leader: Greg Verdine (Harvard University, USA) |
7:30 pm - 8:00 pm | Greg Verdine (Harvard University, USA) "Structural and Mechanistic Investigations in DNA Repair" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Grigory Dianov (University of Oxford, UK) "Regulation of base excision repair in response to DNA damage" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Ueli Hübscher (University of Zurich, Switzerland) "Faithful translesion synthesis by human DNA polymerases over 8-oxo-guanine" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Bruce Demple (Harvard University, USA) "Preventing Genetic Decay via BER of Oxidative Damage" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Recombination Induced Genomic Instability |
| Session Chair / Discussion Leader: Penny Jeggo (University of Sussex, UK) |
9:00 am - 9:30 am | Penny Jeggo (University of Sussex, UK) "The impact of chromatin structure on double strand break repair and signalling" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Shunichi Takeda (Kyoto University, Japan) "Collaboration of BRCA1 and CtIP in cellular tolerance to topoisomerase poisons" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Kyungjae Myung (NIHGR, NIH, USA) "Suppression of genomic instability by RAD5-dependent PCNA polyubiquitination in mammalian cells" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | John Tainer (The Scripps Institute, USA) "Core Structures and Functions of the Mre1/Rad50/Nbs1 Complex in dsDNA End Binding and dsDNA Break Signaling and Repair" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Dale Ramsden (University of North Carolina, USA) "End joining, for better or diverse" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Simon Boulton (London Research Institute, UK) "SPAR1 maintains genome stability through suppression of aberrant recombination events" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Physiological Mutagenesis in the Immune Response |
| Session Chair / Discussion Leader: Nancy Maizels (University of Washington, USA) |
7:30 pm - 8:00 pm | Nancy Maizels (University of Washington, USA) "Targeting immunoglobulin gene diversification" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Heinz Jacobs (Netherlands Cancer Institute, The Netherlands) "Role of PCNA modification in somatic hypermutation" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Pat Gearhart (NIA, NIH, USA) "Hypermutation in immunoglobulin variable and switch regions" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Michael Neuberger (MRC Cambridge, USA) "Antibody gene diversification through DNA deamination" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Rare Human Diseases Associated with Genomic Instability, Neurodegeneration and Premature Aging |
| Session Chair / Discussion Leader: Keith Caldecott (University of Sussex, UK) |
9:00 am - 9:30 am | Keith Caldecott (University of Sussex, UK) "Mammalian single-strand break repair and human disease" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Björn Schumacher (Erasmus University, The Netherlands) "DNA damage and the paradoxical link with longevity" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Sergei Mirkin (Tufts University, USA) "Large-scale expansions of triplet repeats: mechanisms and implications" |
10:35 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Cynthia McMurray (Mayo Clinic, USA) "MSH2/MSH3: a damage sensor" |
11:30am - 11:40 am | Discussion |
11:40 am - 11:55 am | Kevin Hiom (MRC Cambridge, UK) "BRCA1, its interactions and the maintenance of genome stability" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Wim Vermeulen (Erasmus University, The Netherlands) "Mouse models of mutant transcription/repair factor TFIIH" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Excursion: Broughton Castle |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Low-fidelity Replication and Cancer |
| Session Chair / Discussion Leader: Larry Loeb (University of Washington, USA) |
7:30 pm - 8:00 pm | Larry Loeb (University of Washington, USA) "The presence and significance of random mutations in human cancers" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Zvi Livneh (Weizmann Institute, Israel) "Cancer risk assessment using DNA repair enzymatic activity assays: A tool for lung cancer prevention" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Fumio Hanaoka (Gakushuin University, Japan) "In vivo and in vitro studies on DNA polymerase η" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Errol Friedberg (University of Southwestern Texas, USA) "Lessons Learned From the Polκ Mouse" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Mutagenesis |
| Session Chair / Discussion Leader: Tom Kunkel (NIEHS, NIH, USA) |
9:00 am - 9:30 am | Tom Kunkel (NIEHS, NIH, USA) "Dissecting the fidelity of leading and lagging strand replication fidelity in yeast" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Floyd Romesberg (The Scripps Institute, USA) "Mechanisms of induced mutation in E. coli and S. cerevisiae" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Pat Foster (Indiana University, USA) "Stress-induced mutagenesis in E. coli" |
10:30 am - 10:35am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Alan Lehmann (University of Sussex, UK) "The role of polκ in nucleotide excision repair" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Iwona Fijalkowska (Polish Academy of Sciences, Poland)
"Dpb2p, a non catalytic subunit of DNA polymerase epsilon contributes to the fidelity of DNA replication in S. cerevisiae" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Wei Yang (NIDDK, NIH, USA) "Translesion DNA synthesis by E. coli pol II" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Formal Conference Dinner |
7:30 pm - 9:30 pm | Signaling for repair: avoiding excessive mutagenesis |
| Session Chair / Discussion Leader: Joe Jiricny (University of Zurich, Switzerland) |
7:30 pm - 8:00 pm | Joe Jiricny (University of Zurich, Switzerland) "Mismatch repair in unusual settings" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Joyce Lebbink (Erasmus University, The Netherlands) "DNA loop formation by the MutS MutL protein complex during early steps of DNA mismatch repair" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Wei Xiao (University of Saskatchewan, Canada) "Ubiquitination of DNA clamps: a central signaling for repair and tolerance?" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Tom Ellenberger (Washington University, USA) "Specialization of Mammalian DNA Ligases" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Chair’s closing reception |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |