SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | KEYNOTE PRESENTATIONS |
| Chair: Nancy Maizels (University of Washington School of Medicine, Seattle, WA) |
7:40 pm - 8:25 pm | Tom Petes (Duke University Medical Center, Raleigh, NC)
"Recombinogenic and mutagenic properties of the GAA/TTC trinucleotide repeats in yeast" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Richard Kolodner (Ludwig Institute for Cancer Research, La Jolla, CA)
"Identification of the pathways that cells use to prevent genome instability" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CONSEQUENCES OF OXIDATIVE AND ENVIRONMENTAL STRESS |
| Discussion Leader: Bruce Demple (Stony Brook University Medical School, NY) |
9:00 am - 9:30 am | Bruce Demple (Stony Brook University Medical School, NY)
"BER as a crossroads for oxidative DNA repair and mitosis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Peter Burgers (Washington University School of Medicine, St. Louis, MO)
"Rev1 is a switchable activator of mutagenic DNA replication" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Sue Lovett (Brandeis University, Waltham, MA)
"Mutagenesis by a replication template switch" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Claus Desler (Center for Healthy Aging, Copenhagen)
"Mitochondrial dysfunction and dNTP regulation" |
11:35 am - 11:50 am | Sanjay Bharti (Indian Institute of Science, Bangalore)
"The impact of a mutant uracil DNA glycosylase attenuated in AP-DNA binding on maintenance of genomic integrity in E. coli" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Tom Ellenberger (Washington University School of Medicine, St. Louis, MO)
"Structural logic of DNA end joining by ligase III" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HERITABLE REPAIR DEFECTS AND HUMAN DISEASE |
| Discussion Leader: Keith Caldecott (University of Sussex, Falmer, UK) |
7:30 pm - 7:55 pm | Keith Caldecott (University of Sussex, Falmer, UK)
"PARP3 and APLF function cooperatively to accelerate non-homologous end joining" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Yilun Liu (Yale University School of Medicine, New Haven, CT)
"Understanding the complexity of human RECQ helicases in genome maintenance" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Adam Brown (UTHSC, San Antonio)
"The role of BLM in homology-directed repair and oxidative stress" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Simon Boulton (London Research Institute, Cancer Research UK, South Mimms, UK)
"Regulating recombination during the cell cycle" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DNA PROCESSING AND GENETIC STABILITY |
| Discussion Leader: Sue Jinks-Robertson (Duke University Medical Center, Raleigh, NC) |
9:00 am - 9:30 am | Sue Jinks-Robertson (Duke University Medical Center, Raleigh, NC)
"Transcription and mutagenesis: the Top1 connection" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Binghui Shen (Beckman Research Institute, City of Hope, Duarte, CA)
"Functional regulation of FEN1 nucleases and their deficiency in cancer" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Dorothy A. Erie (U. North Carolina, Chapel Hill, NC)
"AFM and single molecule fluorescence studies of mismatch repair" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Johanna Van Oers (Albert Einstein College of Medicine, New York)
"PMS2 endonuclease activity is essential for genome maintenance in somatic and germline cells" |
11:35 am - 11:50 am | Emigdio Reyes (New Mexico State University, Las Cruces)
"The cohesin-like RecN protein stimulates intermolecular DNA interactions in vitro" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | James E. Haber (Brandeis University, Waltham, MA)
"Elevated mutation rate and a distinct spectrum of mutations accompanying double-strand break repair by gene conversion" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | REGULATED MUTAGENESIS |
| Discussion Leader: Myron F. Goodman (University of Southern California, Los Angeles, CA) |
7:30 pm - 7:55 pm | Myron F. Goodman (University of Southern California, Los Angeles, CA)
"Captured alive: The active form of Pol V reveals the mutagenic mechanism of the RecA nucleoprotein filament in the SOS response" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Sven Petersen-Mahrt (London Research Institute, Cancer Research UK, South Mimms, UK)
"AID induced deamination: Targeting and resolution" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Steven Roberts (NIEHS, Research Triangle Park, NC)
"Localized hypermutability caused by chronic alkylation damage to a eukaryotic genome" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Niels deWind (Leiden University Medical Center, Leiden, The Netherlands)
"Mutagenic consequences of transcription at an UV-damaged template" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DNA DAMAGE, CANCER AND AGING |
| Discussion Leader: Orlando Schärer (Stony Brook University, NY) |
9:00 am - 9:30 am | Orlando Schärer (Stony Brook University, NY)
"Regulation of endonuclease activity in human nucleotide excision repair" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | JoAnn Sekiguchi (University of Michigan Medical School, Ann Arbor, MI)
"Aberrant chromosomal rearrangements and tumorigenesis caused by an hypomorphic Artemis disease allele" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Sandy Chang (Yale University School of Medicine, New Haven, CT)
"How telomeres prevent engagement of the DNA damage response at chromosome ends" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Masaaki Moriya (Stony Brook University, NY)
"Mechanistic analysis of mammalian translesion DNA synthesis" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | John Tainer (Scripps Research Institute, La Jolla, CA)
"Dynamic Mre11-Rad50-Nbs1 DNA repair complexes: Disease-causing mutations and biological outcomes" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | MUTATIONAL HOTSPOTS AND RARE DISEASES |
| Discussion Leader: Sergei Mirkin (Tufts University, Medford, MA) |
7:30 pm - 7:55 pm | Sergei Mirkin (Tufts University, Medford, MA)
"To switch or not to switch: Repeat expansions during DNA replication" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Marcel Tijsterman (Leiden University Medical Center, Leiden, The Netherlands)
"Mutagenic properties of G4 DNA" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Lionel Gellon (Tufts, Boston)
"The Ctf18-RFC complex stabilizes trinucleotide repeats in yeast by a cohesion-independent mechanism" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Kevin Hiom (University of Dundee, Scotland, UK)
"FancJ and the maintenance of inherently unstable DNA sequences" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | POLYMERASE INFIDELITY AND CANCER |
| Discussion Leader: Fumio Hanaoka (Gakushuin University, Tokyo, Japan) |
9:00 am - 9:30 am | Fumio Hanaoka (Gakushuin University, Tokyo, Japan)
"Tumorigenesis induced by chronic treatment with UV-B in Polη- and Xpc-deficient mice" |
9:30 am - 9:40 am | Discussion |
9:40 am- 10:05 am | Wei Yang (NIDDK, NIH, Bethesda, MD)
"Mechanism for translesion DNA synthesis" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Roger Woodgate (NICHHD, NIH, Bethesda, MD)
"High throughput screen for TLS DNA polymerase inhibitors" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Maria Jose Martin (CBMSO, Madrid)
"Double-strand break repair by human DNA polymerse μ: at the edge between genome stability and variability" |
11:35 am - 11:50 am | Jason Sheltzer (MIT, Boston)
"Aneuploidy drives genomic instability" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Thomas A. Kunkel (NIEHS, Research Triangle Park, NC)
"Repair of DNA replication errors in budding yeast" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EXPLOITING MUTAGENESIS FOR THERAPY |
| Discussion Leader: Lawrence A. Loeb (University of Washington School of Medicine) |
7:30 pm - 7:55 pm | Lawrence A. Loeb (University of Washington School of Medicine, Seattle, WA)
"Mutational heterogeneity in human cancers: Origin and consequences" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Zvi Livneh (Weizmann Institute of Science, Rehovot, Israel)
"DNA damage tolerance in mammalian chromosomes: A high resolution glimpse" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Kawai Kuong (U. Illinois, Urbana)
"Recombinational repair causing chromosomal damage during thymineless death in E. coli" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Yves Pommier (NCI, NIH, Bethesda)
"Topoisomerases and genomic stability" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |