SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | KEYNOTE PRESENTATIONS |
| Discussion Leader: Bruce Demple (Stony Brook University School of Medicine, Stony Brook, NY) |
7:40 pm - 8:25 pm | Thomas A. Kunkel (NIEHS, Research Triangle Park, NC)
"Determinants of leading and lagging strand DNA replication fidelity"
|
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Titia de Lange (Rockefeller University, New York, NY)
"How telomeres solve the end-protection problem"
|
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BRANCHING PATHWAYS IN MUTAGENESIS |
| Discussion Leader: Robert P.P. Fuchs (CNRS Genome Instability and Carcinogenesis Unit, Marseille, France) |
9:00 am - 9:30 am | Robert P.P. Fuchs (CNRS Genome Instability and Carcinogenesis Unit, Marseille, France)
"The role of dNTP pool size in spontaneous and induced mutagenesis in E. coli"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Roger Woodgate (NICHHD, NIH, Bethesda, MD)
"Characterization of novel E. coli polV mutants"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Group Photo / Coffee Break |
10:45 am - 11:10 am | Helle Ulrich (London Research Institute/CRUK, South Mimms, UK)
"Mechanism of ubiquitin-dependent DNA damage bypass"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:33 am | Joseph Loparo (Harvard Medical School, Boston, MA)
"Concentration-dependent interactions with the sliding clamp serve as a switch for regulating translesion polymerase exchange"
|
11:33 am - 11:38 am | Discussion |
11:38 am - 11:51 am | Matthew Northam (University of Nebraska Medical Center, Omaha, NE)
"Yeast DNA polymerases zeta and Rev1 aid in the bypass of non-canonical secondary structures in DNA"
|
11:51 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Josef Jiricny (University of Zurich, Zurich, Switzerland)
"The mismatch repair interactome"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | OXIDATIVE STRESS AND ENDOGENOUS DNA DAMAGE |
| Discussion Leader: Sarah Delaney (Brown University, Providence, RI)) |
7:30 pm - 7:55 pm | Sarah Delaney (Brown University, Providence, RI)
"Contribution of oxidatively damaged DNA to triplet repeat expansion"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Paul Doetsch (Emory University School of Medicine, Atlanta, GA)
"Transcriptional mutagenesis and oxidative DNA damage"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Alain Nepveu (McGill University, Montreal, Canada)
"Ras-Induced Oxidative Damage and Recruitment of REV1 to Transcribed Regions"
|
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | David M. Wilson (National Institute on Aging, Baltimore, MD)
"Defects in the repair of endogenous DNA damage"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DNA MAINTENANCE PATHWAYS |
| Discussion Leader: Peter Burgers (Washington University School of Medicine, St. Louis, MO) |
9:00 am - 9:30 am | Peter Burgers (Washington University School of Medicine, St. Louis, MO)
"Control of damage-induced mutagenesis through Rev1"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Robert Sobol (Univ. of Pittsburgh School of Medicine, Pittsburgh, PA)
"Exploring the Polβ/XRCC1 interface and the regulation of base excision repair"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | John Tainer (Scripps Research Institute, La Jolla, CA)
"XPD, FEN1 and MRN conformations and complexes: Envisioning DNA repair interfaces with transcription and replication"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:33 am | Celine Walmacq (National Cancer Institute, NIH, Bethesda, MD)
"Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage"
|
11:33 am - 11:38 am | Discussion |
11:38 am - 11:51 am | Benu Das (National Cancer Institute, NIH, Bethesda, MD)
"PARP1 is a critical cofactor for Tyrosyl-DNA phosphodiesterase (TDP1) repair function"
|
11:51 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Maria Falkenberg Gustafsson (University of Gothenburg, Sweden)
"Linking transcription to DNA replication in human mitochondria"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RECOMBINATIONAL PATHWAYS, GOOD AND BAD |
| Discussion Leader: Maria Jasin (MSKCC, New York, NY) |
7:30 pm - 7:55 pm | Maria Jasin (MSKCC, New York, NY)
"Protecting the genome through homologous recombination"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Dale Ramsden (University of North Carolina, Chapel Hill, NC)
"Assessing the fidelity of the 'error-prone' double strand break repair pathway"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Mitch McVey (Tufts University, Medford, MA)
"Multiple translesion polymerases are involved in mutagenic DNA double-strand break repair"
|
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Simon Boulton (London Research Institute/CRUK, South Mimms, UK)
"Molecular Basis of T-loop disassembly and suppression of telomere fragility by RTEL1"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PROBLEMATIC DNA STRUCTURES |
| Discussion Leader: Robert Lahue (National University of Ireland, Galway) |
9:00 am - 9:30 am | Robert Lahue (National University of Ireland, Galway)
"Genes that promote trinucleotide repeat expansions"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Nancy Maizels (University of Washington School of Medicine, Seattle, WA)
"Solving the problems posed by DNA structures"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 10:58 am | Jennifer Surtees (SUNY Buffalo School of Medicine, Buffalo, NY)
"Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions"
|
10:58 am - 11:02 am | Discussion |
11:02 am - 11:15 am | Ivaylo Ivanov (Georgia State University, Atlanta, GA)
"Repair complexes of FEN1, DNA and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability"
|
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Catherine Freudenreich (Tufts University, Medford, MA)
"Factors governing repair fidelity within CAG trinucleotide repeats"
|
11:45 am - 11:55 am | Discussion |
11:55 am - 12:08 pm | Sabrina Mansilla (Insituto Leloir Fundación, Buenos Aires, Argentina)
"A failure to downregulate the negative regulator of TLS, p21, upon UV irradiation generates damaged-DNA replication defects and triggers apoptosis and genomic instability"
|
12:08 pm - 12:13 pm | Discussion |
12:13 pm - 12:26 pm | Catherine Potenski (NYU School of Medicine, New York, NY)
"Role of the RNaseH2 complex and the Srs2 DNA helicase in maintaining genome stability and mutation avoidance"
|
12:26 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | HYPERMUTATION IN THE MICROBIAL WORLD |
| Discussion Leader: Jeffrey H. Miller (UCLA, Los Angeles, CA) |
7:30 pm - 7:55 pm | Jeffrey H. Miller (UCLA, Los Angeles, CA)
"The origin of mutations in the pools of nucleoside diphosphates generated by the degradation of RNA"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Sue Lovett (Brandeis University, Waltham, MA)
"DNA structure-associated mutational hotspots"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Francesca Storici (Georgia Institute of Technology, Atlanta, GA)
"Mechanisms of RNA-driven DNA damage and repair"
|
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Sue Jinks-Robertson (Duke University Medical Center, Raleigh, NC)
"Topoisomerase I and genome stability in yeast"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TISSUE-SPECIFIC AND AGING-RELATED MUTAGENESIS |
| Discussion Leader: Christi Walter (UT Health Sciences Center, San Antonio, TX) |
9:00 am - 9:30 am | Christi Walter (UT Health Sciences Center, San Antonio, TX)
"The paternal age effect - A disruption of genetic integrity mechanisms in the male germline"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Myron F. Goodman (University of Southern California, Los Angeles, CA)
"A drunkard's walk approach to generate mutational diversity - ssDNA scanning by AID & APOBEC C-deaminases"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Diane Cabelof (Wayne State University, Detroit, MI)
"Accumulation of somatic copy number variants with age"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:33 am | Sonia Franco (Johns Hopkins University, Baltimore, MD)
"PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T lineage lymphomagenesis"
|
11:33 am - 11:38 am | Discussion |
11:38 am - 11:51 am | Federica Polato (National Cancer Institute, NIH, Bethesda, MD)
"Understanding the role of CtIP in DSB repair"
|
11:51 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Keith Caldecott (University of Sussex, Falmer, UK)
"New insights into DNA strand break repair"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MUTATION AND DISEASE |
| Discussion Leader: Lawrence A. Loeb (University of Washington School of Medicine) |
7:30 pm - 7:55 pm | Lawrence A. Loeb (University of Washington School of Medicine, Seattle, WA)
"Mutational heterogeneity in human cancers: Origin and consequences"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Niels de Wind (Leiden University Medical Centre, Leiden, Netherlands)
"A mismatch repair pathway that regulates responses to photolesions by controlling translesion synthesis"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Reuben Harris (University of Minnesota, Minneapolis, MN)
"Enzyme Catalyzed DNA Deamination in Multiple Human Cancers"
|
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Kristin Eckert (Pennsylvania State University, State College, PA)
"Microsatellite stability in the human genome: When interrupting is a good thing"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |