SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: From Molecular Mechanisms to Human Disease |
| Discussion Leader: Robert Lahue (National University of Ireland, Galway) |
7:40 pm - 8:20 pm | David Pellman (Howard Hughes Medical Institute and Harvard Medical School)
"How Cell Division Errors Shape Cancer Genomes"
|
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Karlene Cimprich (Stanford University School of Medicine)
"Mechanisms for RNA-Induced Genome Instability"
|
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RNA-Mediated Mutagenesis |
| Discussion Leader: Sue Jinks-Robertson (Duke University) |
9:00 am - 9:30 am | Sue Jinks-Robertson (Duke University)
"Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Hilde Nilsen (University of Oslo)
"The Human Base Excision Repair Enzyme SMUG1 Directly Interacts with DKC1 and Contributes to RNA Quality Control"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Andrew Jackson (University of Edinburgh)
"Enzymatic Removal of Ribonucleotides from DNA is Essential for Mammalian Genome Integrity and Development"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Hannah Klein (New York University School of Medicine)
"Srs2 DNA Helicase and Exo1 Nuclease Are Novel Players in Preventing Mutagenesis Arising from Misincorporated Ribonucleotides in DNA"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Andres Aguilera (CABIMER, University of Seville)
"R-Loops and Chromatin Structure in Transcription-Associated Genome Instability"
|
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Genomic and Chromosomal Alterations |
| Discussion Leader: Jessica Downs (University of Sussex) |
6:00 pm - 6:25 pm | Jessica Downs (University of Sussex)
"The Tumour Suppressor Protein BAF180 Functions Within the PBAF Chromatin Remodelling
Complex to Promote Sister Chromatid Cohesion and Maintain Genome Stability"
|
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Shamil Sunyaev (Harvard Medical School and Brigham & Women's Hospital)
"Properties of Human Germ-Line and Somatic Mutations: Insight from Sequencing Studies"
|
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Tovah Day (Dana Farber Cancer Institute)
"Identifying Genetic Determinants of Chromosomal Translocations"
|
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Anton Gartner (University of Dundee)
"DNA Damage Profiling by Massive C. elegans Next Generation Sequencing: Mutagenesis, Repair Links to Cancer Genomes"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Decision Points: Repair or Mutate? |
| Discussion Leader: Simon Boulton (London Research Institute/Clare Hall Laboratories) |
9:00 am - 9:30 am | Simon Boulton (London Research Institute/Clare Hall Laboratories)
"Genome Stability and the Control of Homologous Recombination"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Susan Lees-Miller (University of Calgary)
"Structural and Functional Insights into Non-Homologous End Joining"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Kyungjae Myung (National Human Genome Research Institute)
"Identification of Small Molecules that Sensitize DNA Repair Deficiency: New Tools for Basic and Translational Research"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Jose Ruiz (University of Seville-CABIMER)
"DNA-PK-Mediated Phosphorylation of Human Pol Lambda During NHEJ"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Svend Pedersen-Mahrt (IFOM-Fondazione Istituto FIRC di Oncologia Molecolare)
"Kinetics of DNA Repair Pathway Choice"
|
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | DNA Polymerases and Translesion Synthesis |
| Discussion Leader: Robert Fuchs (CNRS, Marseille) |
6:00 pm - 6:25 pm | Robert Fuchs (CNRS, Marseille)
"Damaged DNA Replication: The Critical Choice Between Translesion Synthesis and Damage Avoidance"
|
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:45 pm | Mark Sutton (University at Buffalo, SUNY)
"DNA Polymerase IV (DinB) Mutations Impaired for Genetic Interactions with the Escherichia coli Replicase"
|
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:00 pm | Andrew Robinson (University of Groningen)
"Spatial Regulation of Mutagenic DNA Polymerase V in E. coli"
|
7:00 pm - 7:05 pm | Discussion |
7:05 pm - 7:15 pm | Richard Pomerantz (Temple University School of Medicine)
"Human DNA Polymerase Theta Promotes Microhomology Mediated Endjoining and Inhibits
Homologous Recombination"
|
7:15 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Roger Woodgate (National Institute of Child Health and Human Development)
"Using Error-Prone DNA Polymerases to Uncover the Molecular Mechanisms of Ribonucleotide Repair"
|
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Challenges at the Replication Fork |
| Discussion Leader: Peter Burgers (Washington University School of Medicine) |
9:00 am - 9:30 am | Peter Burgers (Washington University School of Medicine)
"Functional Interactions Between Rev1 and DNA Polymerase Zeta for Mutagenesis"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Virginia Zakian (Princeton University)
"Pif1 Family Helicases Suppress Genome Instability at G-Quadruplex Motifs"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Susan Lovett (Brandeis University)
"Template Switch Mutagenesis in Bacteria and Yeast"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Luis Blanco (Spanish Research Council)
"PrimPol, an Archaic Enzyme Involved in Replication Fork Re-Start and Translesion Synthesis in Human Cells"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Laura Bailey (University of Sussex)
"PrimPol, a Novel Lesion Bypass DNA Polymerase Involved in Genome Replication in Eukaryotes"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Thomas Kunkel (National Institute of Environmental Health Science)
"Interrelationships Between Replication Fidelity and Genome Composition"
|
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Editing and Repair |
| Discussion Leader: Titia Sixma (Netherlands Cancer Institute) |
6:00 pm - 6:25 pm | Titia Sixma (Netherlands Cancer Institute)
"The Role of the MutS Sliding Clamp in DNA Mismatch Repair"
|
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Alison Gammie (Princeton University)
"Mismatch Repair, Mutation Accumulation and Cancer"
|
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Polina Shcherbakova (University of Nebraska Medical Center)
"A Recurrent Cancer-Associated DNA Polymerase Epsilon Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading"
|
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Thomas Helleday (Karolinska Institute)
"Targeting Cancer by MTH1 Inhibition"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | DNA Structural Challenges |
| Discussion Leader: Nancy Maizels (University of Washington School of Medicine) |
9:00 am - 9:30 am | Nancy Maizels (University of Washington School of Medicine)
"Homology-Directed Repair at DNA Nicks: Implications for Cancer, Applications to Gene Therapy"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Andre Nussenzweig (National Cancer Institute)
"Mechanisms That Maintain Genome Stability"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Christopher Pearson (University of Toronto)
"MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Jean Gautier (Columbia University Medical Center)
"Mechanisms of MYC-Driven Genome Instability"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Julian Sale (MRC Laboratory of Molecular Biology, Cambridge)
"Replication Stress, Structured DNA and the Promotion of Epigenetic Instability"
|
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Targeted Mutagenesis |
| Discussion Leader: Sergei Mirkin (Tufts University) |
6:00 pm - 6:25 pm | Sergei Mirkin (Tufts University)
"Repeat-Mediated Genome Instability: From Length Changes to Mutagenesis and Gross Chromosomal Rearrangements"
|
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Myron Goodman (University of Southern California)
"Regulation of E. coli DNA Polymerase V Activity by an Intrinsic DNA-Dependent ATPase"
|
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Steven Roberts (National Institute of Environmental Health Science)
"Hypermutation of ssDNA in Yeast and Human Cancers"
|
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Christi Walter (University of Texas Health Science Center at San Antonio)
"Age-Associated Activation of p53 in Spermatogenic Cells is Associated with APE Polyubiquitination and Increased Mutagenesis"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |