Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Mechanistic Origins of Mutagenesis
Discussion Leader: Karlene Cimprich (Stanford University School of Medicine, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Wei Yang (National Institutes of Health, USA)
"Structural Insights into Error-Prone DNA Synthesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Johannes Walter (Harvard Medical School, USA)
"Mechanisms of DNA Replication-Coupled Repair"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA-Dependent Mutagenesis
Discussion Leader: Simon Boulton (The Francis Crick Institute, United Kingdom)
9:00 am - 9:25 am
Andrés Aguilera (CABIMER, University of Seville, Spain)
"The Role of Chromatin in RNA-Mediated Genome Instability"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Selected from Poster Abstracts: Martin Reijns (MRC Human Genetics Unit, The University of Edinburgh, United Kingdom)
"Ribonucleotide Excision Repair Deficiency and PARP Inhibition Cause Synthetic Lethality"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Thanos Halazonetis (University of Geneva, Switzerland)
"Mechanisms of Oncogene-Induced DNA Replication Stress"
10:15 am - 10:25 am
Discussion
10:25 am - 10:35 am
Selected from Poster Abstracts: Jacqueline Barlow (University of California, Davis, USA)
"DNA Fragile Site Breakage and Chromosomal Rearrangements"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Houra Merrikh (University of Washington, USA)
"Transcription-Coupled Repair Promotes Rapid Evolution of Antibiotic Resistance"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Sarah Cohen (Centre de Biologie Intégrative de Toulouse, France)
"Senataxin Resolves RNA:DNA Hybrids Forming at DNA Double-Strand Breaks to Prevent Translocations"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Duncan Smith (New York University, USA)
"Transcription Drives DNA Replication Initiation and Termination in Human Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Wei Yang (National Institutes of Health, USA), Houra Merrikh (University of Washington, USA) and Titia Sixma (Netherlands Cancer Institute, The Netherlands)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mutagenesis Due to Environmental and Endogenous Sources of DNA Damage
Discussion Leader: Serena Nik-Zainal (University of Cambridge, United Kingdom)
7:30 pm - 7:55 pm
Ketan Patel (MRC Laboratory of Molecular Biology, United Kingdom)
"Aldehyde-Dependent Mutagenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Reuben Harris (University of Minnesota / Howard Hughes Medical Institute, USA)
"Cancer Mutagenesis by Antiviral APOBEC Enzymes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Remi Buisson (Massachusetts General Hospital Cancer Center / Harvard Medical School, USA)
"APOBEC3A Drives Hotspot Passenger Mutations at DNA Stem-Loops in Cancers"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Titia Sixma (Netherlands Cancer Institute, The Netherlands)
"Allosteric Regulation of (De)ubiquitination in DNA Repair"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Damage Avoidance: Lesion Bypass and Template Switching
Discussion Leader: Johannes Walter (Harvard Medical School, USA)
9:00 am - 9:25 am
Aidan Doherty (University of Sussex, United Kingdom)
"Deciphering the Roles of Primase-Polymerase in Excision Repair"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Selected from Poster Abstracts: Seungwoo Chang (Harvard Medical School, USA)
"Dynamic Protein-Protein Interaction Networks Within the E. coli Replisome Determine Damage Tolerance Pathway Choice"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Thomas Kunkel (National Institute of Environmental Health Sciences, NIH, USA)
"Studies of the Mechanisms of DNA Replication Fidelity in Budding Yeast"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Susan Rosenberg (Baylor College of Medicine, USA)
"Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Connor Clairmont (Harvard Medical School / Dana-Farber Cancer Institute, USA)
"TRIP13 Inactivates REV7 and Enhances DSB End Resection"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Selected from Poster Abstracts: Alessandro Vindigni (Saint Louis University, USA)
"Redefining Replication Stress Response Pathways in BRCA1-Deficient Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Ashby Morrison (Stanford University, USA)
"Carcinogen Susceptibility Is Regulated by Genome Architecture and Predicts Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mutagenesis in Low Complexity and Repetitive Sequences
Discussion Leader: Roger Woodgate (National Institutes of Health, USA)
7:30 pm - 7:55 pm
Eric Brown (Perelman School of Medicine, University of Pennsylvania, USA)
"ATR and WEE1 Inhibition Cause Replication Fork Collapse at Repetitive Sequences"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Agnel Sfeir (New York University Langone Medical Center, USA)
"Telomere Dynamics in Cancer Biology (Mechanism of Alternative End Joining)"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Catherine Freudenreich (Tufts University, USA)
"Investigating the Effects of Structure Specific Endonucleases on Fragility of the Flex1 (AT)n Sequence Within Common Fragile Site FRA16D"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Sergei Mirkin (Tufts University, USA)
"Repeat-Mediated Genome Instability in Dividing and Non-Dividing Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genome Instability and Mutagenesis in Disease
Discussion Leader: Reuben Harris (University of Minnesota / Howard Hughes Medical Institute, USA)
9:00 am - 9:25 am
Simon Boulton (The Francis Crick Institute, United Kingdom)
"Initiating Recombination at ALT Telomeres"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Selected from Poster Abstracts: Kyle Miller (University of Texas at Austin, USA)
"Chromatin Regulation of Genome and Epigenome Stability"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Selected from Poster Abstracts: Gabriel Balmus (Wellcome Trust/Cancer Research UK Gurdon Institute, United Kingdom)
"ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Andre Nussenzweig (National Cancer Institute, NIH, USA)
"Mechanisms of Replication Fork Collapse During S Phase"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Peter McKinnon (St. Jude Children's Research Hospital, USA)
"R-Loops Are Pathogenic in Neurodegenerative Genome Instability Syndromes"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Katharina Schlacher (University of Texas MD Anderson Cancer Center, USA)
"Mitochondrial DNA Fork Protection by FANCO/RAD51C Suppresses Metabolic Reprogramming and Inflammation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Robert Brosh (National Institute on Aging, NIH, USA)
"G-Quadruplexes Stall the Mitochondrial Replisome and Are Associated with Sites of Mitochondrial Genetic Variation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Replication Stress and the Consequences of Failure to Complete Replication
Discussion Leader: Eric Brown (Perelman School of Medicine, University of Pennsylvania, USA)
7:30 pm - 7:55 pm
David Pellman (Dana-Farber Cancer Insitute / Harvard Medical School, USA)
"Mechanisms Generating Localized Complex Chromosomal Rearrangements"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Massimo Lopes (Institute of Molecular Cancer Research, University of Zurich, Switzerland)
"Replication Fork Remodelling upon Cancer-Relevant Replication Stress"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Raymond Monnat (University of Washington, USA)
"Landscape and Consequences of DNA Damage Repair Deficiency Across The Cancer Genome Atlas"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Philippe Pasero (Institute of Human Genetics, CNRS, France)
"Cellular Responses to Spontaneous Replication Stress"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understanding the Origins of Mutagenesis in Cancer
Discussion Leader: Ketan Patel (MRC Laboratory of Molecular Biology, United Kingdom)
9:00 am - 9:25 am
Serena Nik-Zainal (University of Cambridge, United Kingdom)
"Validating Mutational Signatures In Vitro and Developing Clinical Applications Based on Mutational Signatures"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Selected from Poster Abstracts: Bettina Meier (University of Dundee, United Kingdom)
"Using Massive C. elegans Whole-Genome Sequencing to Investigate Mutational Signatures of DNA Repair Deficiency and Carcinogen Exposure"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
James Haber (Brandeis University, USA)
"Mutations Created During Repair of a Broken Chromosome"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Anna Malkova (University of Iowa, USA)
"Mutation Clusters and Chromosomal Rearrangements Associated with Homologous Recombination"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Peter Ly (Ludwig Institute for Cancer Research / University of California, San Diego, USA)
"Mitotic Errors Promote a Diverse Spectrum of Simple and Complex Genomic Rearrangements"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Selected from Poster Abstracts: Lana Talmane (The University of Edinburgh, United Kingdom)
"Protein Binding as Selective Filter for New Mutations at Regulatory Sites in Germline and in Cancers"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Georgios Karras (University of Texas MD Anderson Cancer Center, USA)
"Fantastic Genome Instability Mutants and Where to Find Them"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Emerging Themes in Mutagenesis: From Concept to Clinic
Discussion Leader: Julian Sale (MRC Laboratory of Molecular Biology, United Kingdom)
5:30 pm - 5:55 pm
Daniel Jarosz (Stanford University, USA)
"A Stress Response that Supports Survival and Proliferation of Highly Mutated Cells"
5:55 pm - 6:05 pm
Discussion
6:05 pm - 6:30 pm
Roger Greenberg (University of Pennsylvania, USA)
"The G2 Checkpoint: Gatekeeper for Genome Stability and Inflammatory Signaling"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Selected from Poster Abstracts: Gerry Crossan (MRC Laboratory of Molecular Biology, United Kingdom)
"Pre-Meiotic Germ Cell Development Threatens Genome Integrity"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Josep Forment (AstraZeneca, United Kingdom)
"Targeting the DNA Damage Response in Cancer Treatment"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure