Conference Description
The Mutagenesis GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.
The 2024 Gordon Research Conference on Mutagenesis will focus on the underlying causes and consequences of mutations. The genomes of all organisms are consistently under attack by both endogenous and endogenous mutagens, which can change the genetic code. These changes can cause various diseases such as cancer and antimicrobial resistance development. One important feature of the conference will be bringing together of scientists studying a wide range of questions in the field of mutagenesis and are employing diverse range of cutting-edge approaches across various species.
The conference will focus on the fundamental molecular and genetic mechanisms that drive various genome alterations. The meeting will explore the physiological and pathological consequences of mutagenesis in human health, antibiotic resistance development, adaptive and innate immunity, neurodegenerative disease, and cancer. The major focus of the meeting will be to explore how major processes such as DNA replication and transcription contribute to mutagenesis. Furthermore, the inherent properties within the DNA itself such as sequence context or secondary structures that make certain regions of the genome more susceptible to mutagenesis and genetic alterations will be discussed. The conference will include talks by established and young investigators that are leaders in the field, as well as talks selected from submitted abstracts. The conference will also include extensive poster sessions coupled with ample time for discussion and networking between participants at all career stages in an inclusive and diverse atmosphere.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by February 17, 2024. Please check back for updates.
Keynote Session: Critical Mutagenesis Mechanisms
Discussion Leaders
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Peter Burgers (Washington University School of Medicine, United States)
Speakers
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Susan Lovett (Brandeis University, United States)
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Julian Sale (MRC Laboratory of Molecular Biology, United Kingdom)
Replication-Fork Associated Mutations
Discussion Leaders
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Lorraine Symington (Columbia University Irving Medical Center, United States)
Speakers
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Joseph Loparo (Harvard Medical School, United States)
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Dmitry Gordenin (National Institute of Environmental Health Sciences, National Institutes of Health, United States)
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Iwona J. Fijalkowska (Institute of Biochemistry and Biophysics Polish Academy of Sciences, Poland)
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Wei Yang (National Institutes of Health, United States)
DNA Damage and Mutagenesis
Discussion Leaders
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Hannes Lans (Erasmus Medical Center, The Netherlands)
Speakers
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Agnel Sfeir (Memorial Sloan Kettering Cancer Center, United States)
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Martin Taylor (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
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Roger Woodgate (National Institutes of Health, United States)
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Gilad Evrony (New York University Grossman School of Medicine, United States)
Transcription Associated Mutagenesis
Discussion Leaders
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Duncan Smith (New York University, United States)
Speakers
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Andrés Aguilera (CABIMER, University of Seville, Spain)
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Karlene Cimprich (Stanford University School of Medicine, United States)
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Philippe Pasero (Institute of Human Genetics (IGH) / University of Montpellier / CNRS, France)
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Marco Foiani (IFOM ETS, The AIRC Institute of Molecular Oncology, Italy)
The Influence of DNA Sequence on Mutagenesis
Discussion Leaders
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Sergei Mirkin (Tufts University, United States)
Speakers
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Mitch McVey (Tufts University, United States)
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Catherine Freudenreich (Tufts University, United States)
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Graham Erwin (Stanford University, United States)
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Jeannine Gerhardt (Weill Cornell Medicine, United States)
Mutagenesis Mechanisms in Cancer
Discussion Leaders
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Agnel Sfeir (Memorial Sloan Kettering Cancer Center, United States)
Speakers
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Polina Shcherbakova (Eppley Institute for Research in Cancer and Allied Diseases, United States)
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David Pellman (Dana-Farber Cancer Insitute / Harvard Medical School, United States)
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Lorraine Symington (Columbia University Irving Medical Center, United States)
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Puck Knipscheer (Hubrecht Institute, The Netherlands)
How Exogenous and Endogenous DNA Damage Leads to Mutagenesis
Discussion Leaders
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Roger Woodgate (National Institutes of Health, United States)
Speakers
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Bevin Engelward (Massachusetts Institute of Technology, United States)
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David Rueda (Imperial College London, United Kingdom)
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Peter Burgers (Washington University School of Medicine, United States)
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Kevin Lang (University of Minnesota, United States)
Barrier Induced Mutagenesis
Discussion Leaders
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Catherine Freudenreich (Tufts University, United States)
Speakers
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Sergei Mirkin (Tufts University, United States)
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Raluca Gordan (Duke University, United States)
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Nayun Kim (University of Texas Health Science Center at Houston, United States)
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Frederic Chedin (University of California, Davis, United States)
The Ultimate Consequences of Mutations and Evolution
Discussion Leaders
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Kevin Lang (University of Minnesota, United States)
Speakers
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Daniel Jarosz (Stanford University, United States)
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Megan Behringer (Vanderbilt University, United States)
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Sarah Fortune (Harvard T.H. Chan School of Public Health, United States)
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Hannes Lans (Erasmus Medical Center, The Netherlands)
The GRC Power Hourâ„¢
Organizers
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Susan Lovett (Brandeis University, United States)