Saturday |
1:30 pm - 4:30 pm | Arrival and Check-in |
3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:15 pm - 4:00 pm | Keynote Session: Studies of Leading and Lagging Strand DNA Replication Fidelity |
| Discussion Leader: Aishwarya Prakash (The University of South Alabama, USA) |
3:15 pm - 3:55 pm | Thomas Kunkel (National Institute of Environmental Health Sciences, NIH, USA) "Studies of Leading and Lagging Strand DNA Replication Fidelity" |
3:55 pm - 4:00 pm | Discussion |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | The Interface Between Replication and Repair |
| Discussion Leader: Michelle Scotland (University at Buffalo, USA) |
5:30 pm - 5:45 pm | David Gallo (University of Toronto, Canada) "The Roles and Regulation of Rad5, Mgs1 and Pso2 at Stressed DNA Replication Forks in S. cerevisiae" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:05 pm | Norma Keogh (Centre for Chromosome Biology, National University of Ireland Galway, Ireland) "DNA Mismatch Repair Complex MutSβ and Trinucleotide Repeat Expansions" |
6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:25 pm | Kelsey Temprine (Memorial Sloan Kettering Cancer Center, USA) "Evolvability in Melanoma Mediated by Pol?" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:45 pm | Luis Cortez (Washington State University, USA) "APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template During DNA Replication" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:05 pm | Supawat Thongthip (The Rockefeller University, USA) "Fan1 Deficiency Results in DNA Interstrand Crosslink Repair Defects, Enhanced Tissue Karyomegaly, and Organ Dysfunction" |
7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Gregory Williams (University at Buffalo, USA) "The Role of Mismatch Repair (MMR) Factors in Trinucleotide Repeat Expansion (TNR) Disorders" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Sunday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Mutagenesis, Enzyme Function, and Disease |
| Discussion Leader: Kelsey Temprine (Memorial Sloan Kettering Cancer Center, USA) |
9:00 am - 9:15 am | Bogdan Fedeles (Massachusetts Institute of Technology, USA) "The Mutagenic Base 5-Aza-5,6-Dihydrocytosine, Generated by Synthetic, Antiviral Nucleosides, Is Efficiently Repaired in Double Stranded DNA by the NTH Glycosylase" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Martin Reijns (MRC Human Genetics Unit, The University of Edinburgh, United Kingdom) "The Mutational Cost of Chromatin and Regulatory Protein Binding" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Michelle Scotland (University at Buffalo, USA) "Deciphering the Mechanisms of DNA Polymerase Switching in E. coli" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Nicole Antczak (Northeastern University, USA) "Active Site Loops of Y-Family DNA Polymerases Human Pol Kappa and E. coli DinB Contribute to Their Specificity and Activity" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Zubaidah Ramdzan (Goodman Cancer Centre, McGill University, Canada) "CUT Domains Stimulate APE1 Activity and Confer Resistance to Treatments" |
10:35 am - 10:40 am | Discussion |
10:40 am - 10:55 am | Faye-Marie Vassel (Massachusetts Institute of Technology, USA) "Unmasking the Many Faces of Rev7/Mad2L2: A Multitasking Translesion Synthesis Protein Involved in Modulating Chemotherapeutic Efficacy and Beyond" |
10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Mentorship Component: What's Next? Finding Your Niche |
| Discussion Leader: Gregory Williams (University at Buffalo, USA) |
1:30 pm - 2:30 pm | Panel Discussion |
| "What's Next? Finding Your Niche" |
|
- Thomas Kunkel (National Institute of Environmental Health Sciences, NIH, USA)
- Julian Sale (MRC Laboratory of Molecular Biology, United Kingdom)
|
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |