Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Genome Instability Mediated by Simple DNA Repeats
Discussion Leader: Gregory Williams (National University of Ireland, Galway, Ireland)
3:45 pm - 4:25 pm
Sergei Mirkin (Tufts University, USA)
"Genome Instability Mediated by Simple DNA Repeats"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome Instability and Mutagenesis in Disease
Discussion Leader: Claudia Aloisi (ETH Zurich, Switzerland)
7:30 pm - 7:45 pm
Sarah Cohen (Centre de Biologie Intégrative de Toulouse, France)
"Senataxin Resolves RNA:DNA Hybrids Forming at DNA Double-Strand Breaks to Prevent Translocations"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Hanna Foster (The Francis Crick Institute, United Kingdom)
"The Role of ATMIN Homo-Oligomerisation in Regulation of ATM Signaling"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
David Lopez Martinez (University of Oxford, United Kingdom)
"Activation of the Fanconi Anemia DNA Repair Pathway by Dephosphorylation"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Lana Talmane (The University of Edinburgh, United Kingdom)
"Protein Binding as a Selective Filter for New Mutations at Regulatory Sites in Germline and in Cancers"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Remi Buisson (Massachusetts General Hospital Cancer Center / Harvard Medical School, USA)
"APOBEC3A Drives Hotspot Passenger Mutations at DNA Stem-Loops in Cancers"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Mark Ragheb (University of Washington, USA)
"Inhibiting Evolution of Antibiotic Resistance"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The Interface Between Replication and Repair
Discussion Leader: David Lopez Martinez (University of Oxford, United Kingdom)
9:00 am - 9:15 am
Claudia Aloisi (ETH Zurich, Switzerland)
"Sequence-Specific Detection of Rare DNA Damage Events"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Brandon Case (Wesleyan University, USA)
"Coordinated Actions of Four ATPase Sites on UvrA2 During Initiation of Nucleotide Excision Repair"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Vincenzo D'Angiolella (University of Oxford, United Kingdom)
"Ubiquitylation Control of Ribonucleotide Reductase in DNA Replication Stress and Mutagenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Bradley Klemm (National Institute of Environmental Health Sciences, NIH, USA)
"Novel Mode of Allosteric Activation of E. coli dGTPase by Single-Stranded DNA"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Nicole Stantial (Duke University, USA)
"Exploring the Mutagenic Role of Topoisomerase 2"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
John Pribis (Baylor College of Medicine, USA)
"Ciprofloxacin Induces Antibiotic Cross-Resistance Mutagenesis via Stress-Responsive Mutagenic-Break Repair"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: What Is Next? Discovering the Post-PhD Career Landscape
Discussion Leader: Nicole Stantial (Duke University, USA)
1:30 pm - 2:30 pm
Panel Discussion
Discovering the Post-PhD Career Landscape
Josep Forment (AstraZeneca, United Kingdom)
Catherine Freudenreich (Tufts University, USA)
Sergei Mirkin (Tufts University, USA)
Brian Plosky (Molecular Cell, Cell Press, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes