Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Mutational Footprints of Cancer Therapies
Discussion Leader: Daniel Pers (Vanderbilt University, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:25 pm
Nuria Lopez-Bigas (IRB Barcelona, Spain)
"The Mutational Footprints of Cancer Therapies"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Structure Promoted Mutagenesis
Six student/postdoc talks chosen from the abstracts
Discussion Leader: Jasmina Büchel (ETH Zurich, Switzerland)
7:30 pm - 7:45 pm
Kaitlynne Bohm (Washington State University, United States)
"Genome-wide maps of rare UV photoproducts reveal distinct patterns of DNA damage formation in chromatin"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Chiara Masnovo (Tufts University, United States)
"Coordination between leading and lagging strand synthesis prevents GAA repeat instability"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Rebecca Brown (Tufts University, United States)
"THO and TRAMP Complexes Prevent Transcription-Replication Conflicts, DNA Breaks, and CAG Repeat Contractions"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Daniel Pers (Vanderbilt University, United States)
"Investigating the mechanisms behind R-Loop induced lethality upon replication-transcription conflicts"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
MaryElizabeth Stein (Penn State College of Medicine, United States)
"The Significance of G-Quadruplex Variation to Mutagenesis: Sequence and Topology Differentially Impact Human DNA Polymerase Fidelity"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Diane Shao (Boston Children's Hospital, United States)
"Duplex Consensus Sequencing for Accurate Detection of Somatic Mutations in the Human Fetal Brain"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Enzyme Promoted Mutagenesis
Six student/postdoc talks chosen from the abstracts
Discussion Leader: Chiara Masnovo (Tufts University, United States)
9:00 am - 9:15 am
Ryan Campbell (Florida State University , United States)
"Mechanistic Description of Metabolic Adaptation via Enzyme Recruitment"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Kara Pytko (Pennsylvania State University, United States)
"Characterization of Human DNA Polymerase Delta-Mediated Replication of a Difficult-to-Replicate-Sequence"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Daria Ostroverkhova (Queen's University, Canada)
"Specific Patterns of Mutations Induced by Mutated DNA Polymerase Epsilon in Endometrial Cancer Genomes"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Juan Carvajal Garcia (Vanderbilt University, United States)
"Oxidative Damage Makes Nucleotide Excision Repair Mutagenic"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Anna Johnson (Vanderbilt University, United States)
"A Small Molecule that Inhibits the Evolution of Antibiotic Resistance"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Savannah Weeks-Pollenz (University of Florida , United States)
"Escherichia coli Single-Stranded DNA Binding Protein Inhibits the Helicase Activity of the XPD/Rad-3 like Helicase, DinG, on Duplex DNA Substrates"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Got a PhD - What Awaits You After?
Discussion Leaders: Savannah Weeks-Pollenz (University of Florida , United States)
1:30 pm - 2:30 pm
Panel Discussion
A Glimpse into the Diverse World of Scientific Careers Following Higher Education
Sue Jinks-Robertson (Duke University Medical Center, United States)
Shana Sturla (ETH Zurich, Switzerland)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes