| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Recent Developments in Human Toxicoses |
| Chair: Richard Lewis (University of Queensland, AU)
Discussion Leader: Kitty Cardwell (USDA, ARS, Washington, DC) |
| 7:30 pm | Welcome |
| 7:40 pm | Overview |
| 7:50 pm | Benjamin Suarez-Isla, University of Chile, Santiago, Chile
Recent PSP expansion in Chile: Trends, impacts and possible causes |
| 8:20 pm | Chris Wild, University of Leeds, UK
Early life exposures to aflatoxin in West Africa: Disease mechanisms, adverse health effects and approaches to prevention |
| 8:50 pm | Jan Landsberg, Florida Marine Research Institute, St. Petersburg, FL
PSP in pufferfish: A new public health issue in Florida |
| 9:20 pm | Discussion |
| 9:45 pm | Social |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Toxin Genes: Evolutionary Significance of Toxic Metabolites |
| Chair: Kathleen Rein (Florida International University, Miami, FL)
Discussion Leader: TBA |
| 9:00 am | Chair Overview |
| 9:10 am | Francois Lutzoni, Duke University, Durham, NC
Paradise lost: Secondary fungal metabolism and loss of lichen symbiosis |
| 9:40 am | Jeff Wright, University of North Carolina, Wilmington, NC
Attack and defend: The function and evolution of bioactive or toxic metabolites |
| 10:10 am | Discussion |
| 10:25 am | Break / Photo |
| 11:00 am | Mohammed Marahiel, Philipps-Universitat Marburg, Marburg, Germany
Spying on natures drug factories: Understanding the reaction mechanism of nonribosomal peptide synthesis |
| 11:30 am | Scott Kroken, Diversa, San Diego, CA
Horizontal gene transfer or vertical inheritance: Fumonisin clusters in Fusarium and Cochliobolus |
| 12:00 pm | "Hot Topic" - to be chosen from posters |
| 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Toxins and Metabolite Chemistry |
| Chair: Kevin James (Institute of Technology, Cork, Ireland)
Discussion Leader: Barbara Blackwell (Agriculture and Agrifoods, Canada) |
| 7:30 pm | Overview |
| 7:40 pm | Chris Miles, Agricultural Research, New Zealand
Identification of novel yessotoxins |
| 8:10 pm | John Simon, Duke University, Durham, NC
Characterization of the binding and structure-activity relationships of the interaction of ochratoxin A with human serum albumin and implications for renal toxicity |
| 8:40 pm | Paul Howard, National Center for Toxicology Research, Jefferson, AK
A DNA reactive compound in Fusarium culture material: Could it cause DNA damage in human esophageal tissue? |
| 9:10 pm | "Hot Topic" - to be chosen from posters |
| 9:20 pm | Discussion |
| 9:45 pm | Posters / Social |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Molecular, Cellular, and Environmental Control of Toxin Synthesis |
| Chair: Bruce Campbell (USDA-ARS, Albany, CA)
Discussion Leader: Gaspar Taroncher-Oldenburg (Nature Biotechnology, New York, NY) |
| 9:00 am | Overview |
| 9:10 am | Marion Beremand, Texas A&M University, College Station, TX
New insights into the molecular control of trichothecene biosynthesis |
| 9:40 am | Richard V. Snyder, Florida International University, Miami, FL
Evidence for bacterial contribution of polyketide synthase to K. brevis |
| 10:10 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am | Alan Dobson, University of Cork, Ireland
Cloning, characterization and physiological control of genes involved in ochratoxin A biosynthesis. |
| 11:30 am | Deana Erdner, Woods Hole Oceanographic Inst., MA
Environmental and cellular aspects of saxitoxin biosynthesis in Alexandrium dinoflagellates |
| 12:00 pm | "Hot Topic" - to be chosen from posters |
| 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Advancements in Detection Methods |
| Chair: Steve Musser (USFDA/CFSAN, College Park, MD)
Discussion Leader: Mark Poli (USAMRIID, Frederick, MD) |
| 7:30 pm | Overview of Satellite Workshop - This talk will summarize the presentations and demonstrations given at the Satelite Workshop that was organized by vice Chair Steven Musser and Marc Poli for Friday and Saturday 13 and 14 June 2003 at the Mount Desert Island Biological Laboratory (NIH), Bar Harbor, ME. |
| 7:50 pm | Robert Dickey, USFDA, Dauphin Island, AL
Toward replacing the mouse bioassay: Method intercomparison for determination of PbTx in shellfish. |
| 8:15 pm | Norbert Maier, University of Vienna, Austria
The quest for ochratoxin A-selective molecularly imprinted polymers for solid-phase extraction: Merits and limitations |
| 8:40 pm | Tom Pearson, USDA/ARS/GMPRC, Manhattan, KS
Detecting mycotoxins in foods using reflectance/transmittance and near-infrared spectroscopy |
| 9:05 pm | Yasmine Bottein Dechraoui, NOAA Marine Biotoxins Program, Charleston, SC
Biomonitoring toxin exposure using blood collection cards |
| 9:25 pm | Discussion |
| 9:45 pm | Social / Posters |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanisms of Toxicity and Protection |
| Chair: Bruce Jarvis (University of Maryland, College Park, MD)
Discussion Leader: John Ramsdell (NOAA/NOS, Charleston, SC) |
| 9:00 am | Overview |
| 9:10 am | Tom Murray, University of Georgia, Athens, GA
Convergence of sodium channel activator and NMDA receptor signaling in cerebrocortical neurons |
| 9:40 am | Peter Constable, University of Illinois, Urbana, IL
Cardiovascular dysfunction as a mechanism for fumonisin-induced equine leukoencephalomalacia and porcine pulmonary edema |
| 10:10 am | Lyndon Llewellyn, Australian Institute of Marine Science, Townsville, AU
Pharmacokinetics of the paralytic shellfish toxins in nature: Multiple receptors and their potential role in resistance and accumulation |
| 10:40 am | Coffee Break |
| 11:00 am | Thomas Kensler, John Hopkins, Baltimore, MD
Strategies for protection against aflatoxin-induced hepatocarcinogenesis |
| 11:30 am | Edmund Creppy, University of Bordeaux, France
Epigenetic effects induced by okadaic acid |
| 12:00 pm | "Hot Topic" - to be chosen from posters |
| 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 4:30 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Advances in Control Strategies |
| Chair: John Richard (Romer Laboratories, Union, MO)
Discussion Leader: Tony Glenn (USDA/ARS/SAA, Athens, GA) |
| 7:30 pm | Overview |
| 7:40 pm | Robert Brown, USDA/ARS/SRRC, New Orleans, LA
Proteomics for gene discovery and aflatoxin control |
| 8:10 pm | Larry Antilla, Arizona Cotton Research and Protection Council, Phoenix, AZ
The successful application of atoxigenic strain technology to reduce mycotoxin levels in the field |
| 8:40 pm | Discussion |
| 9:00 pm | Invited student presentations
Chairs: Greg Boyer (SUNY, Syracuse, NY) & Ken Voss (USDA/ARS, Athens, GA) |
| 9:20 pm | Discussion |
| 9:45 pm | Posters / Social |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Toxicity: Susceptibility Factors and Mechanisms of Resistance |
| Chair: Wentzel Gelderblom (PROMEC, Tygersberg, South Africa)
Discussion Leader: Luis Botana (University of Santiago della Compositella) |
| 9:00 am | Overview |
| 9:10 am | William Abraham, University of Miami, Miami, FL
Airway responses to aerosolized brevetoxins in an animal model of asthma: Mechanisms and effects of novel antagonists |
| 9:40 am | Tom Rand, St Mary's University, Halifax, NS
Biological consequences of Stachybotrys chartarum exposures on the lung |
| 10:10 am | Discussion |
| 10:25 am | Coffee Break |
| 10:45 am | Lynn Grattan, University of Maryland Medical School, Baltimore, MD
Potential health risks of domoic acid exposure to Native Americans in the Pacific Northwest |
| 11:15 am | Tony Futerman, Weizmann Institute of Science, Rehovot, Israel
Upstream of growth and differentiation factor 1 - A putative fumonisin resistance ceramide synthase in mammalian cells |
| 11:45 am | "Hot Topic" - to be chosen from posters |
| 11:55 pm | Discussion |
| 12:15 pm | Business meeting |
| 12:30 pm | Lunch |
| 4:30 pm | Poster session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Defining and Quantifying Risk |
| Chair: Helen Shurz-Rogers (Center for Disease Control and Prevention, Atlanta, GA)
Discussion Leader: Sarah Henry (USFDA/CFSAN, College Park, MD) |
| 7:30 pm | Overview |
| 7:40 pm | Lorraine Backer, National Center for Environmental Health, Atlanta, GA
Epidemiologic studies of marine phycotoxins |
| 8:10 pm | Janee Gelineau-van Waes, University of Nebraska, Omaha, NE
Fumonisin exposure and insufficient folate as susceptibility factors for increased risk of neural tube defects: Lessons learned from a mouse model |
| 8:40 pm | Felicia Wu, Rand Corporation, Pittsburgh, PA
Bt corn's potential economic impact through mycotoxin reduction: A comparison between developed and developing countries |
| 9:10 pm | Discussion |
| 9:30 pm | Closing Remarks |
| 9:45 pm | Social |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
