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Mycotoxins and Phycotoxins

Gordon Research Conference

June 17 - 22, 2007
Chairs Kenneth A. Voss and Kathleen S. Rein
Vice Chairs Robert W. Dickey and Barbara A. Blackwell

Conference Description

The Gordon Research Conference on Mycotoxins and Phycotoxins provides an international forum for the presentation and discussion of leading edge research on the biology, chemistry, risk assessment and toxicology of fungal, algal, and cyanobacterial toxins that are known food or water contaminants. A primary goal of the meeting is to create the critical mass of creative thinking necessary to unravel the complex food safety problem presented by naturally occurring food toxins. With this in mind, considerable effort is made to provide numerous opportunities for participants to interact in a relaxed environment that promotes the free exchange of ideas on topics vital to the future of research on the identification, toxicology, control, and regulation of natural toxins in foods. The conference is unique in that it bring together a diverse multidisciplinary group of research scientists who are all ultimately focused on solving the same practical problem --- ensuring the safety and security of the food supply!

Conference Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff / Conference Overview by Co-Chairs: Kelly Rein and Ken Voss
7:40 pm - 9:30 pmHUMAN EXPOSURES
Session Chair: Mark Poli (Integrated Toxicology Division USAMRIID, Fort Detrick, MD)
Discussion Leader: David Miller (Carleton University, Ottawa, Canada)
7:40 pm - 7:45 pm Chair overview
7:45 pm - 8:15 pm Paul Alan Cox (Institute for Ethnomedicine, Jackson Hole, WY)
"Cyanotoxins and neurodegenerative illness"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:50 pm George Bailey (Linus Pauling Institute, Environmental Health Science Center and, Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR)
"Chlorophylls as inhibitors of aflatoxin B1 uptake, genomic damage, and tumor induction: from animal models to humans"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Wayne Carmichael (Department of Biological Sciences, Wright State University, Dayton, OH)
"A human intoxication event by cyanotoxins during renal dialysis treatment in Caruaru, Brazil: 10 years after"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPUBLIC HEALTH AND EPIDEMIOLOGY
Session Chair: Helen Schurz-Rogers (Centers for Disease Control, Atlanta, GA)
Discussion Leader: Lorraine Backer (National Center for Environmental Health, Chamblee, GA)
9:00 am - 9:10 am Chair overview
9:10 am - 9:40 am Chris Wild (Centre for Epidemiology and Biostatistics, University of Leeds, UK)
"Biomarkers in the investigation of human exposure to mycotoxins: the case of deoxynivalenol"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am George Luber (Centers for Disease Control, Atlanta, GA)
"Active surveillance for Ciguatera in Culebra, Puerto Rico: estimating the the burden of disease in a hyper-endemic region"
10:15 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Pauline Jolly (Department of Epidemiology, University of Alabama - Birmingham, Birmingham, AL)
"Association of aflatoxin B1 albumin adducts and cellular immune impairments in humans"
11:10 am - 11:15 am Discussion
11:15 am - 11:45 am Gordon Shephard (Medical Research Council, Tygerburg, South Africa)
"Risk assessment for fumonisins in the former Transkei region of South Africa"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pm Lora Fleming (Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, FL)
"Recent advances in Florida red tide and human health"
12:20 pm - 12:30 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmDETECTION TECHNOLOGIES FOR ORGANISMS AND TOXINS
Session Chair: Robert Dickey (Food and Drug Administration, Dauphin Island, AL)
Discussion Leader: Barbara Blackwell (Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, Ottawa, Canada)
7:30 pm - 7:40 pm Chair Overview of Satellite Workshop - Summary of presentations and demonstrations given at the Satellite Workshop (June 15-16, 2007, Mount Desert Island Biological Laboratory (NIH), Bar Harbor, ME) by vice-Chairs Bob Dickey and Barbara Blackwell
7:40 pm - 8:10 pm Michael Appell (National Center for Agricultural Utilization Research, USDA - Agricultural, Research Service, Peoria, IL)
"Molecularly imprinted polymers for Fusarium mycotoxins"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Kristian Nielsen (BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark)
"Fungal metabolites and mycotoxins in silage - do we know enough about this complex environment?"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Jonathan Deeds (FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD)
"New perspectives on detection and public health impacts of palytoxin"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNEW TOXINS, METABOLITES AND SYNTHESIS
Chair: Peter Scott (Health Canada, Tunney's Pasture, Ottawa, Canada)
Discussion Leader: Robert Gawley (University of Arkansas, Fayetteville, AR)
9:00 am - 9:10 am Chair Overview
9:10 am - 9:40 am Craig Forsyth (Deptartment of Chemistry, University of Minnesota, Minneapolis, MN)
"Synthesis and detection of the azaspiracid marine toxins"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am Manfred Metzler (Institute of Food Chemistry and Toxicology, University of Karlsruhe, Karlsruhe, Germany)
"Novel metabolites and genotoxic potential of Alternaria toxins"
10:15 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Timothy Jamison (Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA)
"Epoxide-opening cascades for ladder polyether synthesis"
11:10 am - 11:15 am Discussion
11:15 am - 11:45 am Michael Quilliam (Institute for Marine Biosciences, National Research Council Canada, Halifax, Canada)
"Structure elucidation of new PSP toxin analogues - 2 new subgroups encompassing almost 20 new PSP analogs"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pm Franz Berthiller (Center for Analytical Chemistry, Department of Agrobiotechnology (Tulln), University of Natural Resources and Applied Life Sciences, Vienna, Austria)
"The role of deoxynivalenol-3-glucoside for plants and animals"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmTOXIN BIOSYNTHESIS
Chair: Charles Woloshuk (Botany and Plant Pathology, Purdue University, West Lafayette, IN)
Discussion Leader: Cynthia Heil (College of Marine Sciences, University of South Florida, St. Petersburg, FL)
7:30 pm - 7:40 pm Chair Overview
7:40 pm - 8:10 pm Fran Van Dolah (Center for Coastal Environmental Health and Biomolecular Research, NOAA, Charleston, SC)
"Polyketide synthase gene expression in the Florida red tide dinoflagellate, Karenia brevis"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Liangcheng Du (Chemistry Department, University of Nebraska, Lincoln, NE)
"Decoration of a fungal reduced polyketide chain, oxidoreductions and esterifications in fumonisin biosynthesis"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Brett Neilan (School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia)
"Novel alkaloid biosynthesis pathways in toxic cyanobacteria"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREGULATION OF TOXIN BIOSYNTHESIS AND TOXICITY
Chair: Richard Pierce (Mote Marine Laboratory, Sarasota, FL)
Discussion Leader: Jiujiang Yu (Food and Feed Safety Research, USDA Agricultural Research, New Orleans, LA)
9:10 am - 9:40 am Vera Trainer (NOAA Fisheries, Northwest Fisheries Science Center, Seattle, WA)
"Mechanisms of shellfish resistance to biotoxins"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am Rainer Kurmayer (Austrian Academy of Sciences, Institute for Limnology, Mondsee, Austria)
"Phylogenetic and geographic distribution of transposases inactivating the synthesis of the toxic heptapeptide microcystin in cyanobacteria"
10:15 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Bruce Campbell (Plant Mycotoxin Research Unit, USDA Agricultural Research Service, Albany, CA)
"Chemogenomic elucidation of mechanisms suppressing and triggering aflatoxin biosynthesis"
11:10 am - 11:15 am Discussion
11:15 am - 11:45 am Mark Wells (Department of Oceanography, University of Maine, Orono, ME)
"Trace metals and diatom toxicity"
11:45 am - 11:50 am Discussion
11:50 am - 12:30 pm "Hot Topics" and Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:15 pm - 7:30 pmBusiness Meeting (Part 1)
(Fill out Conference Evaluation Forms)
7:30 pm - 9:30 pmTOXICOGENOMICS AND MOLECULAR MECHANISMS
Chair: Wayne Bryden (School of Animal Science, University of Queensland, Gatton, Australia)
Discussion Leader: John Berry (Florida International University, Miami, FL)
7:30 pm - 7:40 pm Chair Overview
7:40 pm - 8:10 pm Janee Gelineau-van Waes (Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE)
"Mechanisms of fumonisin teratogenicity in a mouse model"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Kathi Lefebvre (NOAA Fisheries, Northwest Fisheries Science Center, Seattle, WA)
"Sub-acute effects of domoic acid in the vertebrate central nervous system"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Jim Pestka (Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI)
"Nasal tract toxicity of macrocyclic trichothecenes: targets and mechanisms"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:40 am - 9:00 amBusiness Meeting (Part 2)
(Nominations for the next Vice Chair; Discuss future Site & Scheduling preferences; Election of the next Vice Chair; Other)
9:00 am - 12:30 pmMOLECULAR MECHANISMS II
Chair: Tineke Kuiper-Goodman (Bureau of Chemical Safety HPFB, Health Canada, Ottawa, Canada)
Discussion Leader: Robert MacPhail (EPA, Research Triangle Park, NC)
9:00 am - 9:10 am Chair Overview
9:10 am - 9:40 am Alice Hudder (Institute of Environmental Health Sciences, Wayne State University, Detroit, MI)
"Microcystin, mice and microarrays"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am Angela Mally (Institut für Toxikologie, Universität Würzburg, Würzburg, Germany)
"Mechanisms of ochratoxin A toxicity"
10:15 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 am Gerhard Adam (Center for Applied Genetics, Universität für Bodenkultur, Vienna, Austria)
"Ubiquitin availability and proteasome dependent protein degradation limit trichothecene resistance: lessons from wheat cDNAs conferrring deoxynivalenol resistance in yeast"
11:10 am - 11:15 am Discussion
11:15 am - 11:45 am Allen Place (Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD)
"Karlotoxins - sterol targeted dinoflagellate toxins"
11:45 am - 11:50 am Discussion
11:50 am - 12:20 pm Michael Kolomiets (Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX)
"Plant lipoxygenases and oxylipins in pathogenesis and mycotoxin production"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 8:10 pmMEDIATORS OF PLANT PATHOGENISIS
Chair: Javier Plasencia (University of Mexico, UNAM, Mexico City, Mexico)
7:30 pm - 7:35 pm Overview
7:35 pm - 8:05 pm Tony Glenn (Toxicology & Mycotoxin Research Unit, USDA Agricultural Research Service, Athens, GA)
"Fumonisin production and development of maize seedling disease: evidence points to the Sphinx"
8:05 pm - 8:10 pm Discussion
8:10 pm - 9:30 pmECONOMIC IMPACTS
Chair: Mary Trucksess (FDA Center for Food Safety and Nutrition, College Park, MD)
8:10 pm - 8:15 pm Chair Overview
8:15 pm - 8:45 pm Porter Hoagland (Woods Hole Oceanographic Institute, Woods Hole, MA)
"Economic impacts of harmful algal blooms"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Felicia Wu (Department of Environmental & Occupational Health, University of Pittsburgh, Pittsburgh, PA)
"Mycotoxins in ethanol distillation byproducts: economic impacts on the livestock industry"
9:20 pm - 9:30 pm Discussion and Closing Remarks by Rein and Voss
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

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Additional Fee Info

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