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Myelin

Gordon Research Conference

February 1 - 6, 1998
Chairs Bruce D. Trapp and Bernard Zalc
Vice Chair Steven E. Pfeiffer

Conference Program

Sunday Morning, February 1 - Pathogenic Mechanisms of Demyelination
Discussion Leader: William Hickey
  • John Prineas - Evolution of the MS lesion
  • Hans Lassmann - Heterogeneic Pathways of Demyelination in Multiple Sclerosis
  • Moses Rodriguez - The Role of Class I MHC Immune Function in Development of Neurologic Deficits Following Demyelination
  • Andreas Stefferl - Autoantibody: A Critical Component for immune-mediated Demyelination
  • Jack Antel - Susceptibility of human oligodendrocytes to immune-mediated injury
  • Christiane Richter-Landsberg - Hydrogen Peroxide Induces Cell Injury and Mode of Cell Death in Cultured Brain Oligodendrocytes
Scheduled Short Talks
  • Claude Bernard
  • Robert Swanborg

Sunday Evening, February 1 - Glia Cell Origins

Discussion Leader: Kazuhiro Ikenaka
  • Robert Miller - Spatial and Temporal Regulation of Oligodendrocyte Precursor Appearance
  • Barbara Barres - Inhibition of Oligodendrocyte Differentiation by the Notch Pathway
  • Greg Lemke - Transcriptional Control of Schwann Cell Development
  • Carmen Birchmeir - The Role of Neuregulin and Its Receptors, erbB2 and erbB3, in the Development of the Peripheral Nervous System
Scheduled Short Talks
  • Jean Leon Thomas
  • Richard Quarles
  • Kazuhiro Ikenaka

Monday Morning, February 2 - Axonal Pathology in Myelin Disease

Discussion Leader: Stephen Waxman
  • Stephen Waxman - The Axon as a Player in Demyelinating Diseases: Molecular Mechanisms
  • Scott Brady - Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton in Large Neuron
  • Douglas Arnold - MR Imaging of Axonal Damage Associated with Demyelination
  • Richard Rudick - Axonal Transection in MS or Therapeutic implications of myelin and axonal destruction in multiple sclerosis
  • Ian Griffiths - Axonal changes associated with mutation of the PLP gene
  • Kenneth J. Smith - NO and Axonal Degeneration in Demyelinating Diseases
Scheduled Short Talks
  • James Salzer
  • Paul Shrager

Monday Evening, February 2 - Control of Glia Cell Proliferation

Discussion Leader: Mark Noble
  • Mark Noble - Glial differentiation: more complex than we used to think?
  • Martin Raff - Controls on Oligodendrocyte Numbers in the Optic Nerve
  • William Richardson - Spatial and temporal control of oligodendrocyte development: insights from transgenic mice
  • Vittorio Gallo - Regulation Of Oligodendrocyte Progenitor Proliferation Through Ligand- and Voltage-Gated Ionic Channels
Scheduled Short Talks
  • Angeles Rodriguez-Pena
  • Margot Mayer-Proschel
  • Judith Grinspan

Tuesday Morning, February 3 - Regeneration and Remyelination

Discussion Leader: William Blakemore
  • Robin Franklin - Mechanisms of CNS Remyelination
  • James Goldman - Cycling Cells in the Nervous System and their Relevance to Remyelination
  • Regina Armstrong - Platelet-derived Growth Factor (PDGF) and Basic Fibroblast Growth Factor (FGF) in Endogenous Remyelination
  • Ansi Chang - Distribution and characterization of NG-2 cells in MS lesions
  • Annik Baron Von Evercooren - Plasticity of the adult CNS and myelin repair
Scheduled Short Talks
  • Hans Keirsted
  • Richard Reynolds

Tuesday Evening, February 3 - Neural Cell Fate

Discussion Leader: Robert Lazzarini
  • Hugo Bellen - Cellular and Functional Diversity of Drosophila Glia
  • Yoshiki Hotta - Drosophila gcm, and gcm-family in Other Species
  • Rebecca Hardy - Role of QK1 Proteins in Mammalian Neural Cell Fate Decisions
  • Eric Morrow - Basic Helix-loop-helix Transcription Factors in Retinal Development
  • Angela Giangrande - Cellular and Molecular Mechanisms of Glial Differentiation in Drosophila

Wednesday Morning, February 4 - Cellular and Molecular Mechanisms of Myelination

Discussion Leader: Klaus Armin Nave
  • Klaus A. Nave - Introduction
  • Ueli Suter - The Role of PMP22 in Myelination
  • Diez Meijer - Genetic Control of Peripheral Nerve Myelination
  • Peter Brophy - Periaxin's Place in Axon-Glial Interactions in the PNS
  • Melitta Schachner - Lessons from Double Knock-out Mutants Deficient in Myelin Genes
  • David Colman - Molecular Basis of Adhesion in Peripheral Nerve
Scheduled Short Talks
  • Marie Filbin
  • Karen Chandross
  • Lawrence Wrabetz
  • Sara Szuchet

Wednesday Evening, February 4 - Lipid and Protein Trafficking Leading to CNS Myelin Biogenesis

Discussion Leader: Stephen Pfeiffer
  • Jonathan Pevsner - Cellular Mechanisms of Vesicle Docking and Fusion
  • Stephen Pfeiffer - Lipid and Protein Trafficking Leading to Myelin Biogenesis
    (Including brief overview of work by Wendy Macklin who cannot attend)
  • Jackie Trotter - Signalling of Oligodendrocyte GPI-Anchored Proteins Modulated by Inclusion in Specific Lipid Microdomains
  • Ross Smith - Proteins Involved in Cytoplasmic Transport of MBP and mRNA
  • John Carson - Intracellular Trafficking of Connexin-32 mRNA and Protein
Scheduled Short Talks
  • Steven Scherer

Thursday Morning, February 5 - Chairman's Choice

Discussion Leader: Richard Ransohoff
  • Richard Ransohoff - Glial cells and nervous system inflammation: lessons from studies of chemokines
  • Voon Wee Yong - Inflammatory Cytokines and Reactive Astrogliosis
  • Stephen Miller - Antigen Processing and Presentation by Glial Cells
  • John Griffin - Wallerian degeneration: contrast between the CNS and the PNS
  • Harald Neumann - Neuronal control of Immunologically Relevant Gene Expression in the CNS
  • Iain Campbell - Mechanisms of inflammation in the CNS studied in transgenic mice with astrocyte-targeted expression of cytokines
Scheduled Short Talks
  • Akiko Nishiyama
  • Bernd Kieseier

Contributors

We gratefully acknowledge the generosity of the following for their financial support:

Ares-Serono Foundation
Athena Neurosciences
Bayer AG
Biogen, Inc.
Cephalon, Inc.
The Cleveland Clinic Foundation
Johnson & Johnson Professional, Inc.
The National Multiple Sclerosis Society
The Multiple Sclerosis Society of Great Britain and Northern Ireland
The Multiple Sclerosis Society of Canada

Conference Links

Conference History
Additional Fee Info

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