SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 8:00 pm | Introductory Comments by GRC Site Staff / Welcome: Peter Brophy (University of Edinburgh, UK) |
8:00 pm - 9:30 pm | Keynote Lecture |
8:00 pm - 8:15 pm | Introduction: Wendy Macklin (Lerner Research Institute, Cleveland Clinic Foundation, USA) |
8:15 pm - 9:15 pm | David Colman (Montreal Neurological Institute, Canada), Bruce Trapp (Cleveland Clinic Foundation, USA) and Boris Zalc (INSERM, Salpetriere Hospital, France)
"Myelination and Demyelination: Progress, and Major Unsolved Questions" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Junctional complexes, axo-glial interactions and assembly of the node of Ranvier |
| Discussion Leaders: Steven Scherer (University of Pennsylvania, Philadelphia USA) and Ori Peles (Weizmann Institute, Rehovot, Israel) |
9:00 am - 9:10 am | Introductory Remarks: Steven Scherer |
9:10 am - 9:30 am | Lori Isom (University of Michigan, Ann Arbor, USA)
"Sodium channel beta subunits: roles in channel modulation and axo-glial communication" |
9:30 am - 9:50 am | Matt Rasband (Baylor College of Medicine, Houston, USA)
"Mechanisms of CNS node of Ranvier formation" |
9:50 am - 10:10 am | Will Talbot (Stanford University, USA)
"Genetic analysis of myelination in zebrafish" |
10:10 am - 10:30 am | Discussion |
10:30 am - 11:15 am | Group Photo / Coffee Break |
11:15 am - 11:30 am | Commentary and Discussion: Ori Peles |
11:30 am - 11:50 am | Tim Kennedy (Montreal Neurological Institute, Canada)
"Moving Beyond Axon Guidance: Netrin Function During Oligodendrocyte Maturation and Myelination" |
11:50 am - 12:10 pm | Charles Abrams (State University of New York - Downstate Medicine Center, New York, USA)
"Connexins in Myelinating Glia" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Peripheral neuropathies: lessons for Schwann cell biology |
| Discussion Leaders: Kristjan Jessen (University College, London) and Dies Meijer (Erasmus University, Rotterdam, The Netherlands) |
5:30 pm - 5:40 pm | Introductory remarks: Kristjan Jessen |
5:40 pm - 6:00 pm | Ueli Suter (ETH Zurich, Switzerland)
"Concepts learned from disease mechanisms in inherited peripheral neuropathies" |
6:00 pm - 6:20 pm | Hugh Willison (Glasgow University, UK)
"Glycolipid targets for inflammatory injury to Schwann cells in human autoimmune neuropathies" |
6:20 pm - 6:30 pm | Commentary and Discussion: Dies Meijer |
6:30 pm - 6:50 pm | Laura Feltri (San Raffaele Scientific Institute, Milan, Italy)
"New roles for dystroglycan in myelination" |
6:50 pm - 7:10 pm | Joao Relvas (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Regulation of PNS myelination by integrin-linked-kinase (ILK) and associated molecules" |
7:10 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Poster Session |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling and transcriptional regulation in developing myelinating glia |
| Discussion Leaders: Nancy Ratner (Cincinnati Children's Hospital Medical Center, USA) and Jim Salzer (New York University School of Medicine, USA) |
9:00 am - 9:10 am | Introductory remarks: Nancy Ratner |
9:10 am - 9:30 am | Haesun Kim (Rutgers University, Newark, USA)
"Receptor tyrosine kinase signaling that regulates myelination" |
9:30 am - 9:50 am | Mark Verheijen (Vrije Universiteit, Amsterdam, The Netherlands)
"Schwann cell SCAP and SREBP are required for proper myelination" |
9:50 am - 10:00 am | Akiko Nishiyama (University of Connecticut, Storrs, USA)
"The fate of NG2 cells" |
10:00 am - 10:10 am | Leda Dimou (Ludwig-Maximilians-Universität Munich, Germany)
"Lineage analysis and genetic manipulation of glia cells in health and disease" |
10:10 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:00 am | Commentary and Discussion: Jim Salzer |
11:00 am - 11:20 am | Jeff Milbrandt (Washington University School of Medicine, St. Louis, USA)
"Transcriptional Regulation of Myelination" |
11:20 am - 11:40 am | Michael Wegner (University of Erlangen-Nuremberg, Erlangen, Germany)
"Unwrapping the role of Sox proteins in myelination" |
11:40 am - 12:00 pm | Huiliang Li (University College London, UK)
"Post-translational regulation of olig2 function in oligodendrocyte development" |
12:00 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | White matter diseases: lessons for MS? |
| Discussion Leaders: David Rowitch (University of California, San Francisco, USA) and Charles ffrench-Constant (University of Edinburgh, UK) |
5:30 pm - 5:40 pm | Introductory remarks: David Rowitch |
5:40 pm - 6:00 pm | Kleopas Kleopa (The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus)
"CNS demyelination in CMT1X patients and in gap junction mutant mice" |
6:00 pm - 6:20 pm | Julia Edgar (University of Glasgow, UK)
"A role for the oligodendrocyte in supporting the axon: Implications for the demyelinated axon?" |
6:20 pm - 6:30 pm | Commentary and Discussion: Charles ffrench-Constant |
6:30 pm - 6:50 pm | Odile Boespflug-Tanguy (INSERM, Clermont-Ferrand, France)
"Genes involved in leukodystrophies: a glance at glial functions" |
6:50 pm - 7:10 pm | Severine Boillee
"Microglial involvement in motor neuron degeneration in models of ALS" |
7:10 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Poster Session |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Repair and regeneration in vivo |
| Discussion Leaders: Marie Filbin (Hunter College of CUNY, New York, USA) and Anne Baron-Van Evercooren (INSERM, Salpetriere Hospital, Paris, France) |
9:00 am - 9:10 am | Introductory remarks: Marie Filbin |
9:10 am - 9:30 am | Martin Kerschensteiner (Ludwig-Maximilians-University, Munich, Germany)
"Imaging neuro-glial pathology in vivo" |
9:30 am - 9:50 am | Bruce Appel (Vanderbilt University, Nashville, USA)
"In vivo imaging and genetic analysis of axon wrapping by oligodendrocytes" |
9:50 am - 10:10 am | Mary Bunge (University of Miami, Miami, USA)
"Novel transplantation strategies to repair the injured spinal cord" |
10:10 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:00 am | Commentary and Discussion: Anne Baron-Van Evercooren |
11:00 am - 11:20 am | Alain Chedotal (Université Paris 6, Paris, France)
"Myelin Semaphorins" |
11:20 am - 11:40 am | Hans-Werner Mueller (University of Duesseldorf, Germany)
"Inhibition of scarring and neuroprotective intervention to promote spinal cord repair" |
11:40 am - 12:00 pm | Frank Walsh (Wyeth Discovery Research, Collegeville, USA)
"Novel approaches for the treatment of MS - moving beyond immunomodulation" |
12:00 pm - 12:30 pm | Discussion, including 5 minutes from Leanne Rivers (University College London, UK) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Extracellular signaling and myelination in CNS and PNS |
| Discussion Leaders: Robert Miller (Case Western Reserve University,Cleveland, USA) and Klaus-Armin Nave (Max-Planck- Institute of Experimental Medicine, Göttingen, Germany) |
5:30 pm - 5:40 pm | Introductory remarks: Robert Miller |
5:40 pm - 6:00 pm | Carla Taveggia (New York Medical Center, USA)
"Regulation of myelination by Neuregulin 1" |
6:00 pm - 6:20 pm | Hugo Cabedo (Instituto de Neurociencias de Alicante, Spain)
"Regulation of cholesterol biosynthesis in Schwann cells by NRG1" |
6:20 pm - 6:30 pm | Commentary and Discussion: Klaus-Armin Nave |
6:30 pm - 6:50 pm | Jonah Chan (University of Southern California, Los Angeles, USA)
"Strength in numbers: Working together to promote oligodendrocyte differentiation" |
6:50 pm - 7:10 pm | Holly Colognato (State University of New York, Stony Brook, USA)
"Thinking outside the cell: How extracellular matrix molecules influence oligodendrocyte development" |
7:10 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
9:30 pm | Poster Session |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Glial cell death and axonal pathology |
| Discussion Leaders: Larry Wrabetz (San Raffaele Institute, Milan, Italy) and David Attwell (University College London) |
9:00 am - 9:05 am | Introductory remarks: Larry Wrabetz |
9:05 am - 9:25 am | Randal Kaufman (University of Michigan Medical Center, Ann Arbor, USA)
"The Unfolded Protein Response: To live or to die?" |
9:25 am - 9:35 am | Alex Gow (Wayne State University School of Medicine, Detroit, USA)
"The unfolded protein response in vivo" |
9:35 am - 9:55 am | Brian Popko (University of Chicago, USA)
"ER stress modulates the response of oligodendrocytes to inflammation" |
9:55 am - 10:10 am | Lucia Notterpek (University of Florida, Gainesville, USA)
"Intermittent fasting diet enhances protein homeostatic mechanisms and improves motor performance of hereditary neuropathic mice" |
10:10 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:00 am | Commentary and Discussion: David Attwell |
11:00 am - 11:20 am | Scott Brady (University of Illinois, Chicago, USA)
"Myelinating glia and regulation of axonal transport" |
11:20 am - 11:40 am | Ragnhildur Karadottir (University of Cambridge, UK)
"Neurotransmitter signalling to oligodendrocytes and their precursors" |
11:40 am - 12:00 pm | Maria Kukley (University of Bonn, Germany)
"Vesicular release of glutamate along the axons: a new form of fast signalling from neurons to oligodendroglial cells in white matter" |
12:00 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Animal models of demyelination: have we learned anything useful? |
| Discussion Leaders: Robin Franklin (Cambridge University, UK) and Richard Reynolds (Imperial College, London, UK) |
5:30 pm - 5:40 pm | Introductory remarks: Robin Franklin |
5:40 pm - 6:00 pm | Christine Stadelmann (Göttingen University, Germany)
"Myelin damage and repair in multiple sclerosis and experimental models: new insights" |
6:00 pm - 6:20 pm | Ian Duncan (University of Wisconsin, Madison, USA)
"CNS myelin mutants; what have they told us about myelination and human disease" |
6:20 pm - 6:30 pm | Commentary and Discussion: Richard Reynolds |
6:30 pm - 6:50 pm | Lesley Probert (Hellenic Pasteur Institute, Athens, Greece)
"Targeting of neuronal protection pathways in transgenic mice and its effect upon CNS myelination". |
6:50 pm - 7:10 pm | Scott Zamvil (University of California, San Francisco, USA)
"Regulatory APC that modulate T cell-mediated CNS autoimmunity" |
7:10 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |