SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Oligodendrocyte Pathologies |
| Discussion Leader: Klaus Nave (MPI for Experimental Medicine, Göttingen, Germany) |
7:35 pm - 7:40 pm | Introduction to the session |
7:40 pm - 8:00 pm | Masato Nakafuku (Cincinnati Children's Hospital Medical Center)
"Oligodendrocyte development and injury in the immature brain" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Orna Elroy-Stein (Tel-Aviv University, Israel)
"Vanishing White Matter disease: insights from the mouse model" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Jim Goldman (Columbia University Medical Center, New York)
"Oligodendrocyte and Myelin Pathology in Neurodegenerative and Cerebrovascular Diseases" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Ranjan Dutta (Cleveland Clinic)
"Demyelination effects on Memory Function" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transcriptional and Epigenetic Regulation of Myelinating Glia |
| Discussion Leader: David Rowitch (University of California, San Francisco) |
9:00 am - 9:10 am | Introduction to the session |
9:10 am - 9:30 am | Patrizia Casaccia (Mount Sinai School of Medicine, New York)
"Nuclear events during oligodendrocyte differentiation" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Hirohide Takebayashi (Niigata University, Japan)
"Regulation of oligodendrogenesis by phosphoprotein Olig2" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Q. Richard Lu (University of Texas, Southwestern)
"ATP-dependent chromatin remodeling controls oligodendrocyte lineage progression" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:10 am | Group Photo / Coffee Break |
11:10 am - 11:30 am | Michael Wegner (University of Erlangen-Nürnberg, Germany)
"Sox10 in myelinating glia: mechanisms behind its function" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Ben Deneen (Baylor College of Medicine, Texas)
"NFIA inhibits oligodendrocyte differentiation during development and white matter injury" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | John Silberis (UCSF)
"Evidence that oxygen levels regulate neonatal oligodendrocyte maturation via NIF/VHL and WNT signaling" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Adult myelination and repair |
| Discussion Leader: Regina Armstrong (Uniformed Services University, Maryland, USA) |
5:30 pm - 5:40 pm | Introduction to the session |
5:40 pm - 6:00 pm | Leda Dimou (Ludwig-Maximilians University, Munich)
"Oligodendrocyte precursor cells in the adult brain" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Akiko Nishiyama (University of Connecticut)
"Lineage plasticity of NG2 cells during development and repair" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Gabriel Corfas (Children's Hospital Boston)
"Exploring the effects of experience on myelination" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Kaylene Young (University of Tasmania)
"Oligodendrocyte dynamics during normal adulthood" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Biology of Myelin |
| Discussion Leader: Laura Feltri (NY State University, Buffalo) |
9:00 am - 9:10 am | Introduction to the session |
9:10 am - 9:30 am | Elior Peles (Weizmann Institute of Science, Rehovot, Israel)
"Actin regulators in myelinating glia" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Nicolas Tricaud (Institute for Neuroscience, Montpelier, France)
"The epithelial-like polarization of the myelin sheath" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Mikael Simons (MPI for Experimental Medicine, Göttingen)
"Assembly of myelin membrane sheets in the CNS" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Alessandra Bolino (San Raffaele Scientific Institute, Milan)
"Phosphoinositide metabolism and Schwann cell myelination" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Jackie Trotter (Johannes Gutenberg University of Mainz)
"Regulation of MBPmRNA translation in oligodendrocytes" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Gesine Saher (MPI Experimental Medicine, Göttingen)
"Targeting PLP trafficking in Pelizaeus-Merzbacher-Disease" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Neuron-oligodendrocyte communication |
| Discussion Leader: Vittorio Gallo (Children's National Medical Center, Washington DC) |
5:30 pm - 5:40 pm | Introduction to the session |
5:40 pm - 6:00 pm | Dwight Bergles (Johns Hopkins Medical School, Baltimore)
"In vivo dynamics of oligodendrocyte progenitors in the adult CNS" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Dirk Dietrich (University Clinic Bonn, Germany)
"Glutamate signaling and motility of developing oligodendroglia" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:55 pm | María Cecilia Angulo (Paris Descartes University)
"Developmental changes in NG2 cells: new receptors, new channels and new roles" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:20 pm | Douglas Fields (National Institutes of Health, Maryland, USA)
"Regulation of Myelination by Action Potentials" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Axonal regulation of myelination |
| Discussion Leader: William Talbot (Stanford University) |
9:00 am - 9:10 am | Introduction to the session |
9:10 am - 9:30 am | Dies Meijer (Erasmus University, Rotterdam)
"Lgi proteins in PNS myelination" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Kelly Monk (Washington University, St Louis, Missouri)
"Molecular and genetic analysis of Gpr126 in myelination" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Carla Taveggia (San Raffaele Scientific Institute, Milan)
"Regulation of myelination by Neuregulin and secretases" |
10:25 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | David Attwell (University College London)
"Control of myelination by neurotransmitters" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Jonah Chan (University of California, San Francisco)
"Nanofiber Scaffolds for Oligodendrocyte Myelination: Fiber Diameter is Sufficient to Initiate Wrapping" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | David Lyons (University of Edinburgh, UK)
"Role of axon caliber during CNS myelination in vivo" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Rashmi Bansal (University of Connecticut)
"Regulation of myelination by FGF and ERK-MAPK signaling" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Axon-Schwann cell interactions in the PNS injury response |
| Discussion Leader: Ueli Suter (ETH Neuroscience Center, Zurich) |
5:30 pm - 5:40 pm | Introduction to the session |
5:40 pm - 6:00 pm | Kristjan Jessen (University College London)
"c-Jun controls the generation of a dedicated repair cell (Bungner cell) that ensures axonal regeneration in the PNS" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Alison Lloyd (University College London)
"Common pathways in Schwann cell regeneration and tumourigenesis" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:50 pm | David Bennett (King's College, London)
"The mechanisms by which Neuregulin-1 promotes repair following nerve injury" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:05 pm | Hugo Cabedo (Institute for Neuroscience, Alicante, Spain)
"Oncogenic stimuli activate Wallerian degeneration program to induce peripheral nervous system tumours" |
7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Bernard Zalc (Pitié-Salpêtrière, Paris, France)
"Probing the mysteries of the origins and formation of the myelin sheath: in honor of David Colman" |
7:20 pm - 7:30 pm | Jim Salzer (NYU, New York, NY)
"Translating insights into the ecosystem of the peripheral nerve to the clinic: In honor of Jack Griffin" |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nodes of Ranvier and the axon initial segment |
| Discussion Leader: Peter Brophy (University of Edinburgh) |
9:00 am - 9:10 am | Introduction to the session |
9:10 am - 9:30 am | Matthew Rasband (Baylor College of Medicine, Texas)
"Mechanisms of ion channel clustering in axons" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Barbara Zonta (University of Edinburgh)
"Assembly and stability of axonal domains: spotlight on Nfasc186" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Yanqing Zhang (New York University Medical Center)
"Distinct sources and trafficking of proteins to nodes of Ranvier" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Juan Burrone (King's College London)
"Activity-dependent plasticity at the axon initial segment" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Manzoor Bhat (University of North Carolina)
"Developmental Organization of the Axon Initial Segment in Cerebellar Purkinje Neurons" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Juan José Garrido (Instituto Cajal, Madrid)
"Role of cytoskeleton and related kinases in axon initial segment proteins tethering" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Immune effects on myelin pathology and remyelination |
| Discussion Leader: Robin Franklin (University of Cambridge) |
5:30 pm - 5:40 pm | Introduction to the session |
5:40 pm - 6:00 pm | Rudolf Martini (University of Würzburg)
"Neuroinflammation as a disease pathway in myelin disorders" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Charles ffrench-Constant (University of Edinburgh)
"Cellular and molecular mechanisms by which inflammation enhances remyelination" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:55 pm | Ian Duncan (University of Wisconsin School of Veterinary Medicine)
"Directing exogenous OPCs to areas of inflammation; lessons for treating demyelinated lesions?" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Trevor Kilpatrick (University of Melbourne)
"Common determinants of immune dysregulation and the oligodendroglial response during central demyelination: a key role for TAM receptor signaling" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |