SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Therapeutic Approaches to Remyelination |
7:40 pm - 7:50 pm | Discussion Leader: Bruce Trapp (Cleveland Clinic)
"Introduction" |
7:50 pm - 8:20 pm | Brenda Banwell (Children's Hospital Philadelphia)
"A 3D View of Myelin Biology in Pediatric MS: Demyelination, Remyelination and Primary Myelination in the Inflamed Brain"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Steve Goldman (University of Rochester)
"Human Glial Progenitor-Cell Based Treatment and Modeling of Myelin Disease"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Amit Agarwal (Johns Hopkins University, Baltimore)
"Regulation of Oligodendrocyte Progenitors Through AMPA Receptor Signaling"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Progenitor Self-Renewal, Differentiation and Death |
9:00 am - 9:05 am | Discussion Leader: Robert Miller (Case Western University, Cleveland) "Introduction" |
9:05 am - 9:35 am | Diego Cadavid (Biogen Idec, Massachusetts)
"The Clinical Trials Have Arrived: How Are We Going to Measure Remyelination in the Living Human CNS?"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Steve Fancy (University of California, San Francisco)
"Parallel States of Pathological Wnt Signaling in Colon Cancer and Non-Genetic Human White Matter Injury"
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10:15 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
11:00 am - 11:25 am | Fraser Sim (University of Buffalo, SUNY)
"Muscarinic M3R Regulation of Human Oligodendrocyte Progenitor Differentiation"
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11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Margot Mayer-Proschel (University of Rochester)
"Impact of Latent Human Herpesvirus 6 Infections on Myelination"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Paul Tesar (Case Western Reserve University, Cleveland)
"In Vitro Generated OPCs Provide a Platform for Discovery of Myelin Therapeutics"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling Pathways Regulating Myelination in Development and Injury |
| Discussion Leader: Terri Wood (Rutgers Biomedical & Health Sciences, Newark) |
7:30 pm - 7:50 pm | Carmen Birchmeier (Max Delbruck Center for Molecular Medicine, Berlin, Germany)
"A MAPK Gain-of-Function Mutation in Mice Overrides the Mechanisms that Terminate Myelin Growth and Replaces Nrg1/ErbB3 Signals During Schwann Cell Development and Myelination"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Haesun Kim (Rutgers Biomedical & Health Sciences, Newark)
"MAPKs and Myelin Degeneration"
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8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Joel Levine (SUNY, Stony Brook)
"Wnt Signaling, OPCs and Formation of the Glial Scar"
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8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Wendy Macklin (University of Colorado School of Medicine, Denver)
"Role of mTOR in Myelination"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Ben Deneen (Baylor College of Medicine)
"The Daam2 Pathway: A Hub for Wnt Signaling During Developmental and Regenerative Myelination"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Cytoskeleton Control of Myelination |
9:00 am - 9:05 am | Discussion Leader: Ben Barres (Stanford University)
"Introduction" |
9:05 am - 9:30 am | Brad Zuchero (Stanford University)
"How Does the Actin Cytoskeleton Regulate Myelin Wrapping and Compaction?"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Cristina Fernandez-Valle (University of Central Florida)
"The Actin-Binding Protein, Cofilin, is Essential for Formation of Stable Schwann Cell-Axon Contacts and Myelination"
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10:05 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:10 am | Kae-Jiun Chang (Baylor College of Medicine)
"Glial Ankyrins Facilitate Paranodal Axoglial Junction Assembly"
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11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Hauke Werner (Max Planck Institute, Göttingen, Germany)
"Myelin Proteomics Identifies a Key Role for Septin Filaments in Myelin Pathology"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Schanila Nawaz (Max Planck Institute, Göttingen, Germany)
"F-Actin Disassembly Regulates Myelin Sheet Expansion"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Endoplasmic Reticulum Stress and Myelination |
7:30 pm - 7:35 pm | Discussion Leader: Lawrence Wrabetz (SUNY at Buffalo)
"Introduction" |
7:35 pm - 7:50 pm | Hyung Don Ryoo (New York University)
"Unfolded Protein Response in Drosophila"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Kelly Monk (Washington University, St Louis)
"Mutation of Sec63 in Zebrafish Causes ER Stress and Myelin Defects"
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8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Maurizio D'Antonio (San Raffaele Scientific Institute, Milan, Italy)
"Modulating Proteostasis as a Therapeutic Strategy in Hereditary Neuropathies"
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8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Brian Popko (University of Chicago)
"The Integrated Stress Response Provides Protection Against Inflammatory CNS Demyelination"
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9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Axonal Signaling and Remyelination |
9:00 am - 9:10 am | Discussion Leader: David Attwell (University College, London) |
9:10 am - 9:40 am | David Lyons (University of Edinburgh, UK)
"Synaptic Vesicle Release Regulates Myelin Sheath Growth Along CNS Axons In Vivo"
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9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Ragnhildur Thora Karadottir (Cambridge, UK)
"How Neuronal Activity Regulates Myelination and Remyelination"
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10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Nicola Hamilton (University College London, UK)
"Axon-Oligodendrocyte Signalling in Ischaemia"
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11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Robert Fledrich (Max Planck Institute, Göttingen, Germany)
"Schwann Cell Neuregulin-1 is an Endogenous Factor for Myelin Repair"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Metabolic Support of Myelinated Axons |
| Discussion Leader: Klaus-Armin Nave (Max Planck Institute, Göttingen, Germany) |
7:30 pm - 7:50 pm | Aiman Saab (University of Zurich, Switzerland)
"Oligodendroglial NMDA Receptors Regulating Axonal Energy Metabolism"
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7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Jeff Rothstein (Johns Hopkins University)
"Oligodendroglia Metabolic Support of CNS Neurons and Its Dysfunction in Neurodegeneration"
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8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Nancy Ratner (Cincinnati Children's Hospital)
"Oligodendroyctes Regulate the BBB Through NF1/Ras Signaling"
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8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Jeff Milbrandt (Washington University, St Louis)
"Glial Metabolism and Axonal Stability"
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9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Bruce Ransom (University of Washington, Seattle)
"Energy Metabolism of CNS and PNS Axons: The Role(s) of Glial Glycogen"
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9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 8:50 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
8:50 am - 9:00 am | Bill Richardson (University College London) "In Honor of Marie Filbin: Myelin and Regeneration" |
9:00 am - 12:30 pm | Human Fetal and Neonatal Myelin Development and Injury |
9:00 am - 9:10 am | Discussion Leader: David Rowitch (University of California, San Francisco) |
9:10 am - 9:30 am | Arnold Kriegstein (University of California, San Francisco)
"Oligodendrocyte Precursor Cells in Human Cortical Development"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Pierre Gressens (INSERM, Paris, France; Centre for the Developing Brain, KCL, London, UK)
"Mechanisms of Inflammation-Induced Blockade of Perinatal Oligodendrocyte Maturation Blockade"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:00 am | Jim Barkovich (University of California, San Francisco)
"Use of MRI in Assessment of Developmental Myelination and Preterm Neonatal White Matter Injury"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Steven Miller (The Hospital for Sick Children and the University of Toronto)
"White Matter Development in the Preterm Neonate: The Importance of the Everyday"
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11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Tracy Yuen (University of California, San Francisco)
"Oligodendrocyte HIF Function Synchronizes Postnatal Myelination and White Matter Angiogenesis"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Joey Scafidi (Children's National Medical Center, Washington, DC)
"Recovery of Premature Brain Injury Using Epidermal Growth Factor"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Myelin Plasticity |
| Discussion Leader: Patrizia Casaccia (Mount Sinai School of Medicine) |
7:30 pm - 7:40 pm | Sandra Goebbels (Max Planck Institute, Gottingen, Germany)
"Myelin and White Matter Changes in Aged Mice"
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7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Cassandra Sampaio-Baptista (FMRIB Centre, University of Oxford)
"Motor Skill Learning Induces Changes in White Matter Microstructure and Myelination"
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Po Lu (UCLA, Los Angeles, CA)
"Age-Related Myelin Breakdown and Cognitive Impairment"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Philip Horner (University of Washington, Seattle)
"Internodal Length Plasticity"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Mikael Simons (Max Planck Institute, Göttingen, Germany)
"From the Mechanisms of Wrapping to the Plasticity of Myelin Growth in the CNS"
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9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |