Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Evolution of Myelin
We will take a look back about 600 million years. The appearance of myelin is an astounding example of convergent evolution as oligodendrocytes and Schwann cells both appear in vertebrates above the jawless fishes. This session will cover evolutionary origins of prototype myelin and myelinating cells of the CNS and PNS.
Discussion Leaders: William Richardson (University College London, United Kingdom) and Carmen Melendez-Vasquez (Hunter College, City University of New York, USA)
7:40 pm - 8:00 pm
Bernard Zalc (Sorbonne University / INSERM / CNRS, France)
"Breaking the Code of Myelination"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Daniel Hartline (University of Hawaii, USA)
"The Evolution of Myelin in Invertebrates"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Hauke Werner (Max Planck Institute of Experimental Medicine, Germany)
"Glial Ensheathment of Axons in a Non-Myelinated Vertebrate Species"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Megan Corty (Oregon Health & Science University, USA)
"Mechanisms of Axon Ensheathment"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Fetal Myelin
Does myelin have relevance in the fetus? What is the remyelination potential of fetal versus adult type oligodendrocytes? This session will cover fetal origins of oligodendrocytes in human brain. Fetal myelin is particularly important in the PNS of animals that need to move fast at birth. This session will also cover fetal and iPSC-derived stem cells being tested for cell-based myelination therapies.
Discussion Leaders: Jonah Chan (University of California, San Francisco, USA) and Charles ffrench-Constant (University of Edinburgh, United Kingdom)
9:00 am - 9:20 am
Eric Huang (University of California, San Francisco, USA)
"Neuron-Glia Interaction in the Human Ganglionic Eminence"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stephen Crocker (University of Connecticut School of Medicine, USA)
"Using iPS Cells to Understand the Basis for Remyelination Failure in MS"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sonia Mayoral (University of California, San Francisco, USA)
"Developmental CNS Myelination Is Dependent on Axon Caliber, but Not Dynamic Neuronal Signaling"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Tanya Brown (University of Colorado Anschutz Medical Campus, USA)
"PAK1 Regulation of Oligodendrocyte Differentiation and Myelination"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Anne Desmazieres (Institut du Cerveau et de la Moelle Epiniere (ICM), CNRS UMR 7225, INSERM U1127, UPMC-P6 UMR S, France)
"A Dynamic Study of Early Nodal Formation in the Central Nervous System"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Sarah Kucenas (University of Virginia, USA)
"Glial-Glial Interactions in Developmental Myelination"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Nenad Sestan (Yale University, USA)
"Glial Regulation of Neural Circuit Formation and Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Maria Eichel (Max Planck Institute for Experimental Medicine, Germany)
"Myelinating Schwann Cells Restrict Axonal Calibers via CMTM6"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sarah Kucenas (University of Virginia, USA) and Veronique Miron (University of Edinburgh, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin Development in Early Childhood
Session in memory of Dr. Ben Barres . This session will cover mechanisms of developmental myelination, ranging from transcriptional regulation to axo-glia interactions. This scientific session is dedicated to Dr. Ben Barres in celebration of his contribution to the field and dedication to training young scientists.
Discussion Leaders: Elior Peles (Weizmann Institute of Science, Israel) and Michael Wegner (Friedrich-Alexander University Erlangen-Nürnberg, Germany)
7:30 pm - 7:50 pm
Alessandra Bolino (San Raffaele Scientific Institute, Italy)
"Negative Regulators of Myelination"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Richard Lu (Cincinnati Children's Hospital Medical Center, USA)
"Chromatin Remodeling Control of Myelination"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Vittorio Gallo (Children's National Medical Center, USA)
"Environmental Effects on Myelination After Perinatal White Matter Injury"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Lu Sun (Stanford University, USA)
"A Novel Inhibitory Pathway on CNS Myelination"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Meng-meng Fu (Stanford University, USA)
"How Do Oligodendrocytes Make Microtubule Branches?"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adolescent Myelin: Developmental Origins of Psychiatric Diseases
Parents with an adolescent child might easily appreciate that the brain undergoes catastrophic rewiring, but there is also a massive increase in myelination. In pediatrics and child psychiatry there growing recognition that mental health manifestations can be traced to adolescence. This session will cover the growing body of evidence for white matter remodeling in the juvenile and its association with psychiatric illness.
Discussion Leaders: Gabriel Corfas (University of Michigan, USA) and Bruce Trapp (Cleveland Clinic, USA)
9:00 am - 9:20 am
Jay Giedd (University of California, San Diego, USA)
"The Teen Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tomas Paus (University of Toronto, Canada)
"Growth of White Matter in the Adolescent Brain: Myelin or Axon?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Cody Call (Johns Hopkins University, USA)
"Diverse Patterns of Myelination Along Individual Axons in the Adult Cerebral Cortex"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Sarah Förster (University of Cambridge, United Kingdom)
"Functional Heterogeneity of Oligodendrocytes in the Central Nervous System"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Maria Cecilia Angulo (INSERM U894, Paris Descartes University, France)
"Interneurons and OPCs as Romeo and Juliet During Cortical Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mikael Simons (Technical University of Munich, Germany)
"Dynamics of Myelin Formation in Development and Adult"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Alberto Lazari (University of Oxford, United Kingdom)
"On the Relationship Between Myelination of Long-Range Projections and Their Short Term Functional Plasticity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Stefanie Giera (Boston Children's Hospital / Harvard Medical School, USA)
"Microglial TG2 Drives Myelination and Myelin Repair via GPR56/ADGRG1 in Oligodendrocyte Precursor Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin Homeostasis
Myelin, once thought to be an inert insulating membrane, is now accepted as a dynamic structure that changes over time and with environmental stress. This session will discuss concepts related to adult myelin composition and the cross talk between axons and oligodendrocytes and Schwann cells as well as intrinsic mechanisms that regulate myelin adaptations.
Discussion Leaders: Laura Feltri (University at Buffalo, SUNY, USA) and Robert Miller (George Washington University, USA)
7:30 pm - 7:50 pm
Bruno Weber (University of Zurich, Switzerland)
"Cellular Interaction Supporting Axonal Energy Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Bogdan Beirowski (Hunter James Kelly Research Institute, University at Buffalo, SUNY, USA)
"Upholding White Matter and Nerve Integrity by Metabolic Signaling in Enwrapping Glia"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
David Lyons (University of Edinburgh, United Kingdom)
"In Vivo Imaging in Zebrafish Reveals Novel Mechanisms of CNS Myelination"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Robert Hill (Yale University, USA)
"Uncovering Mechanisms of Myelin Plasticity in the Live Brain"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Martin Meschkat (Max Planck Institute for Experimental Medicine, Germany)
"Dynamics of Myelin Turnover in the Adult Mouse CNS"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Myelin Disease: Mechanisms and Treatments
There have been remarkable clinical advances in the treatment of myelin diseases like MS, but still many hurdles to overcome. This session includes international leaders of clinical trials for MS and genetic myelin disorders. We will cover mechanisms of myelin pathology in the adult brain and PNS.
Discussion Leaders: Wendy Macklin (University of Colorado School of Medicine, USA) and Timothy Kennedy (McGill University, Canada)
9:00 am - 9:20 am
Nicolas Tricaud (INSERM, France)
"Treating Demyelinating Peripheral Neuropathies: The Key Role of Schwann Cell Mitochondria"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Adeline Vanderver (Children's Hospital of Philadelphia, USA)
"Pediatric Leukodystrophies"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Claire Davies (University of Edinburgh, United Kingdom)
"Distinct Microglia and Monocyte-Derived Macrophage Functions During Remyelination Revealed by RNAseq"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Gustavo Della Flora Nunes (Hunter James Kelly Research Institute, University at Buffalo, SUNY, USA)
"Prohibitin 1 Preserves Axon and Myelin Integrity in the Peripheral Nervous System"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Lucas Schirmer (University of California, San Francisco, USA)
"Oligodendrocyte-Encoded Potassium Channel Kir4.1 Function Is Essential for White Matter Integrity"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Alasdair Coles (University of Cambridge, United Kingdom)
"Do We Know How and if Treatments Work in Multiple Sclerosis?"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Klaus-Armin Nave (Max Planck Institute of Experimental Medicine, Germany)
"Oligodendroglial Support of Axonal Energy Metabolism: Relevance for Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jennifer Orthmann-Murphy (Johns Hopkins University School of Medicine, USA)
"Remyelination of Specific Axonal Domains in the Somatosensory Cortex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rogue Myelin
Myelinating cells are not always benevolent. Several lines of evidence demonstrate that gliomas are generated from oligodendrocyte precursors. Glial sub-type characteristics are hijacked for glioma to exploit their host environment (to the detriment of the host). This session will cover glioma origins, impact of treatments on white matter including toxic leuko-encephalopathies.
Discussion Leaders: Teresa Wood (New Jersey Medical School, Rutgers University, USA) and Kaylene Young (Menzies Institute for Medical Research, Australia)
7:30 pm - 7:50 pm
Hui Zong (University of Virginia, USA)
"Crowd Control Going Rogue: Cell Competition in Gliomagenesis from Oligodendrocyte Progenitor Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Donald Mabbott (The Hospital for Sick Children, Canada)
"Saving Time in a Bottle: White Matter Plasticity, Neural Communication, and Brain Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Benjamin Deneen (Baylor College of Medicine, USA)
"Dysregulated Gliogenesis Is a Driver of Malignant Glioma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Susan Campbell (Virginia Tech, USA)
"Consequences of Gut Microbiota-Induced Changes on Myelination"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Andrew Caprariello (University of Calgary, Canada)
"Biochemically-Altered Myelin Pathology Triggers Autoimmune Demyelination"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Aging Myelin
How does white matter age, what changes take place that can affect day-to-day function of the growing number of individuals living well past 70 years of age? New evidence shows that common conditions like senile dementia have important white matter components and white matter infarct (“stroke”) is another important example. This session will cover changes in aging myelin structure, function and disease.
Discussion Leaders: Dwight Bergles (Johns Hopkins University School of Medicine, USA) and Kelly Monk (Vollum Institute, USA)
9:00 am - 9:20 am
Anna Williams (University of Edinburgh, United Kingdom)
"Endothelial Dysfunction and White Matter Vulnerability in Cerebral Small Vessel Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Shin Kang (Temple University School of Medicine, USA)
"Age-Related Changes in Translational Expression of Oligodendrocytes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sarah Moyon (Advanced Science Research Center at the Graduate Center, City University of New York, USA)
"Oligodendrocytes, Aging, Epigenetics, DNA Methylation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Tim Czopka (Technical University of Munich, Germany)
"Formation and Remodelling Dynamics of Axon Myelination Patterns Revealed by In Vivo Imaging"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Elisa D'Este (Max Planck Institute for Biophysical Chemistry, Germany)
"The Role of the Subcortical Cytoskeleton in the Organization of the Nodes of Ranvier, and the Interplay Between the Neuronal and the Glial Cytoskeleton"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Matthew Rasband (Baylor College of Medicine, USA)
"Spectrin Cytoskeletons Converge on Nodes of Ranvier"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mithilesh Jha (Johns Hopkins University, USA)
"MCT1 in Schwann Cells Is a Metabolic Mediator of Sensory Axon Myelination During Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin Regeneration and New Therapies
There are many disorders of myelin yet to be addressed with new therapies. What are the approaches being tested in therapy of genetic and autoimmune diseases? Moreover, how do we set up an ideal clinical trial? This session will cover mechanisms of regeneration and how to enhance this after myelin insult in the developing and adult CNS and PNS.
Discussion Leaders: Robin Franklin (University of Cambridge, United Kingdom) and Catherine Lubetzki (Sorbonne University / INSERM / CNRS, France)
7:30 pm - 7:50 pm
Kleopas Kleopa (The Cyprus Institute of Neurology and Genetics, Cyprus)
"Gene Therapy Approaches Targeting Myelinating Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Peter Calabresi (Johns Hopkins University, USA)
"Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Denise Fitzgerald (Queen's University Belfast, United Kingdom)
"Adaptive Immunity in CNS Remyelination. A Key Role for Regenerative T Regulatory Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Violetta Zujovic (Institut du Cerveau et de la Moelle Epinière (ICM), INSERM U1127, France)
"How Adaptive Immunity Shapes the Remyelination Process"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure