Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Remyelination in Multiple Sclerosis and Animal Models
Discussion Leaders: Anne Baron-Van Evercooren (Institut du Cerveau et de la Moelle Epinière (ICM), France) and Klaus Nave (Max Planck Institute for Multidisciplinary Sciences, Germany)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:00 pm
Benedetta Bodini (Paris Brain Institute, Sorbonne University, Paris, France, France)
"Repair in Multiple Sclerosis: an Imaging Approach"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Robin Franklin (Altos Labs, United Kingdom)
"Aging of Adult CNS Progenitors and its Implications for Myelin Regeneration"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Christine Stadelmann-Nessler (University Medical Center Goettingen, Germany)
"De- and Remyelination in Multiple Sclerosis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
V. Wee Yong (University of Calgary, Canada)
"Overcoming Extracellular Matrix Inhibitors to Promote Remyelination"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ben Emery (Oregon Health & Science University, United States)
"Remyelination Failure Triggers MAP3K-Mediated Neurodegeneration"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Interactions in Myelination
Discussion Leaders: Charles ffrench-Constant (University of East Anglia, United Kingdom) and Terri Wood (New Jersey Medical School, Rutgers University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Julia Edgar (University of Glasgow, United Kingdom)
"The Myelinic Channel System: a Highway to the Axon"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Jun Hee Kim (University of Texas Health Science Center at San Antonio, United States)
"Dynamic Communication Between Oligodendrocytes and Neurons"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Sophie Belin (Albany Medical College, United States)
"Mechanical Stimulation and Peripheral Nerve Repair"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Eva-Maria Kramer-Albers (Johannes Gutenberg University Mainz, Germany)
"Genetic Evidence for Extracellular Vesicles Mediating Neuron-Glia Interactions and Glial Support"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Peter Brophy (University of Edinburgh, United Kingdom)
"Some Surprising Routes to the Assembly of Axonal Membrane Domains"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Keiichiro Susuki (Wright State University, United States)
"Roles of Calpains in PNS Injuries"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Anne Desmazieres (Institut du Cerveau et de la Moelle Epiniere (ICM), France)
"Neuron-Microglia Interaction at the Nodes of Ranvier"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Jennifer Orthmann-Murphy (University of Pennsylvania, United States) and Violetta Zujovic (Institut du Cerveau et de la Moelle Epinière (ICM), France)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Oligodendroglial Heterogeneity
Discussion Leaders: Bernard Zalc (Sorbonne University / INSERM / CNRS, France) and Wendy Macklin (University of Colorado School of Medicine, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Ragnhildur Thóra Káradóttir (University of Cambridge, United Kingdom)
"Heterogeneity of Oligodendrocyte Precursors with Aging"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Goncalo Castelo-Branco (Karolinska Institutet, Sweden)
"Transcriptomic and Epigenomic States of Oligodendroglia in Development and Multiple Sclerosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Mathilde Pruvost (CUNY Advanced Science Research Center, United States)
"Oligodendrocyte Progenitors: Nuclear Events Sensing Time and Space"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:35 pm
Nina-Lydia Kazakou (The University of Edinburgh, United Kingdom)
"In Vitro Hetereogeneity of Human Oligodendroglia"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Hauke Werner (Max Planck Institute for Multidisciplinary Sciences, Germany)
"Quantitative Proteome Analysis to Assess Myelin Heterogeneity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Imaging Tools: From Cells to Human Tissue
Discussion Leaders: David Lyons (University of Edinburgh, United Kingdom) and Bruno Stankoff (Brain and Spine Institute (ICM), France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Emmanuel Beaurepaire (École Polytechnique / CNRS, France)
"Advances in Multiphoton Imaging of Myelinated Tissues"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Martina Absinta (Vita-Salute San Raffaele University, Italy)
"Microglia-Mediated Chronic Inflammation in MS Lesions: from MRI to Molecular Pathways"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Heidi Johansen-Berg (University of Oxford, United Kingdom)
"Imaging White Matter Plasticity"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Peter Stys (University of Calgary, Canada)
"Advanced Fluorescence and Raman Spectroscopy of Myelin"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Ethan Hughes (University of Colorado School of Medicine, United States)
"In vivo Three-Photon Microscopy Reveals Region-Specific Differences in Healthy and Regenerative Oligodendrogenesis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Reshmi Tognatta (Gladstone Institutes, United States)
"Extrinsic Inhibition of Remyelination at the Neurovascular Interface"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Tim Czopka (University of Edinburgh, United Kingdom)
"Roles for Oligodendrocyte Precursor Cells in Shaping the Form and Function of Neural Circuits"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Schwann Cell Development and Repair
Discussion Leaders: Laura Feltri (University at Buffalo, SUNY, United States) and James Salzer (New York University Grossman School of Medicine, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:20 pm
Ruth Stassart (Leipzig University, Germany)
"An Adipo-Glial Signaling Axis in Peripheral Nerve Repair"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
Ryan Doan (The Vollum Institute - Oregon Health & Science University, United States)
"Dock1 Regulates Developmental and Regenerative Schwann Cell Myelination"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Claire Jacob (Johannes Gutenberg University Mainz, Germany)
"Understanding Schwann Cell Plasticity Mechanisms to Enhance Regeneration"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Peter Arthur-Farraj (University of Cambridge, United Kingdom)
"The Timing of the Schwann Cell Response to Acute Nerve Injury"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Dies Meijer (University of Edinburgh, United Kingdom)
"The Accumulation and Stability of Kv1 Channels in Myelinated Axons is Driven by LGI3-ADAM23 Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development of Myelinating Glia
Discussion Leaders: Leda Dimou (Ulm University, Germany) and Ben Emery (Oregon Health & Science University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Hyun Kyoung Lee (Baylor College of Medicine, United States)
"Mechanistic Pathways Underlying Oligodendrocyte Development and Repair"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Bruce Appel (University of Colorado School of Medicine, United States)
"Mechanisms of Myelin Sheath Formation in Development"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Fiona Doetsch (University of Basel, Switzerland)
"Glial Diversity in the Adult Neural Stem Cell Niche"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Jayshree Samanta (University of Wisconsin-Madison, United States)
"Enhancing Remyelination by Modulating the TGFb1 Pathway"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Alison Lloyd (University College London, United Kingdom)
"New Roles for Schwann Cells in Peripheral Nerve Biology"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jenea Bin (University of Edinburgh, United Kingdom)
"Importin 13 Regulates Axon Caliber Growth and Myelination"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Marie Bechler (SUNY Upstate Medical University, United States)
"Mechanosensing Controls Myelin Sheath Elongation in the CNS"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Brad Zuchero (Stanford University, United States)
"How Do Oligodendrocytes Wrap Axons? Cell Biological Mechanisms of Myelination"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Multiple Sclerosis: A Therapeutic Perspective
Discussion Leaders: Anna Williams (University of Edinburgh, United Kingdom) and Stefan Bittner (University Medical Center Mainz, Germany)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Ari Green (University of California, San Francisco, United States)
"Remyelination Trials in MS and Biomarkers for Remyelination"
6:30 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Angela Genchi (San Raffaele Research Institute, Italy)
"Exogenous Repair"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Luke Lairson (The Scripps Research Institute, United States)
"Combination-Based Drug Screening for Induced OPC Differentiation Enables Mechanistic Insight and Identification of Optimal Drug Pairs"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Innate Immune Cells in Myelin Damage and Repair
Discussion Leader: Roberta Magliozzi (University of Verona, Italy)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Lukas Amann (Uniklinik Freiburg, Germany)
"Heterogeneity of Myeloid Cells in the CNS"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Veronique Miron (University of Edinburgh, United Kingdom)
"Microglia Regulation of Central Nervous System Myelin Health"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Robert Hill (Dartmouth College, United States)
"Real-Time Dynamics of Myelin Clearance and Repair"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Sebastian Werneburg (University of Massachusetts Chan Medical School, United States)
"Microglia and the Elimination and Recovery of Synapses in Demyelinating Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Inge Huitinga (Netherlands Institute for Neuroscience, The Netherlands)
"Changes in Axons and Myelin in Relation to Microglia Activation in the NAWM of MS"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Hannah Kapell (Heidelberg University, Germany)
"Paranodal Potassium Channels as Neuroprotective Targets in Inflammatory Demyelination"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jerome Hendriks (Hasselt University, Belgium)
"Targeting Lipophagy in Macrophages Promotes Remyelination"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Adaptive Myelination and Remyelination
Discussion Leaders: Maria Cecilia Angulo (Institute of Psychiatry and Neuroscience of Paris (IPNP), France) and Tobias Merson (National Institute of Mental Health, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Maarten Kole (Netherlands Institute for Neuroscience, The Netherlands)
"Cell Circuit Control and Interneuron Myelination"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
Letizia Leocani (Vita-Salute San Raffaele University, Italy)
"Neuromodulation to Promote CNS Repair"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Erin Gibson (Stanford University School of Medicine, United States)
"Timing Myelin: a New Perspective on Circadian Mechanisms of Brain Function and Dysfunction"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
Kaylene Young (Menzies Institute for Medical Research, Australia)
"Myelination Controls Synaptic Plasticity and Homeostasis in the Motor Cortex of Adult Mice"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure