| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Evolution of Complexity in Muscle |
| Discussion Leader: Stephen Tapscott (Fred Hutchinson Cancer Center) |
| 7:40 pm - 8:20 pm | Scott Gilbert (Swarthmore College)
"Dynamic tension: The muscle phenotype in an expanding network" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Mark Q Martindale (University of Hawaii)
"A molecular analysis of the evolutionary origins of mesoderm" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Michael Krause (National Institutes of Health)
"Transcriptional control of C. elegans muscle development and implications for animal myogenesis" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Developmental Specification of Muscle |
| Discussion Leader: Hans Arnold (University of Braunschweig) |
| 9:00 am - 9:20 am | Stephen Devoto (Wesleyan University)
"The origin and fate of the zebrafish dermomyotome: cell behaviors and regulation by Hedgehog signaling" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Margaret Buckingham (Pasteur Institute)
"Pax genes and myogenesis" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Andrew Lassar (Harvard Medical School)
"Id-3 is a direct transcriptional target of Pax3 and Pax7" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break / Group Photo |
| 10:45 am - 11:05 am | Shahragim Tajbakhsh (Pasteur Institute)
"Regulation of myogenic progenitor populations during development" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Gabrielle Kardon (University of Utah)
"Development of the vertebrate limb muscles" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Pascal Maire (Institut Cochin INSERM)
"Six homeoproteins and muscle development" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Nobuko Hagiwara (University of California, Davis)
"The role of Sox6 in fiber type differentiation of fetal skeletal muscle in mice" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Eldad Tzahor (Weizmann Institute of Science)
"The contribution of second heart field cells to the jaw muscle reveals the multi-potential nature of cardio-craniofacial mesoderm" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | Invertebrate and Vertebrate Muscle |
| Discussion Leader: Susan Abmayr (Stowers Institute for Medical Research) |
| 5:30 pm - 5:50 pm | Katja Seipel (Cardiff School of Biosciences)
"Jellyfish striated muscle: evolution and development" |
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:15 pm | Rie Kusakabe (RIKEN Center for Developmental Biology)
"Development and evolution of the lamprey skeletal muscle" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:40 pm | Elizabeth Chen (The Johns Hopkins School of Medicine)
"Actin Cytoskeleton and targeted exocytosis in myoblast fusion" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Mary Baylies (Sloan Kettering Institute)
"Dynamic rearrangement of the actin cytoskeleton is required at the site of myoblast fusion" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Bruce Paterson (National Institutes of Health)
"Stereotypic founder cell patterning and embryonic muscle formatioon in Drosophila require nautilus gene function" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Muscular Dystrophies |
| Discussion Leader: Kay Davies (University of Oxford) |
| 9:00 am - 9:20 am | Maurice Swanson (University of Florida)
"RNA-mediated pathogenesis in myotonic dystrophy" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Peter Currie (Victor Chang Cardiac Research Institute)
"Zebrafish models of muscular dystrophy and muscle regeneration" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Elizabeth McNally (University of Chicago)
"Myoferlin in myoblast fusion" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Richard Lemmers (Leiden University Medical Center)
"Specific sequence variations within the 4q35 region are associated with FSHD" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Luis Garcia (Genethon)
"Muscle function recovery in dystrophic dog after exon skipping gene therapy" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Yi-Wen Chen (Childrens National Medical Center)
"DUX4, a candidate gene of FSHD, encodes a transcriptional activator of PITX1" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Toshifumi Yokota (Childrens National Medical Center)
"Morpholino-mediated multi-exon skipping restores dystrophin to potentially therapeutic levels in canine X-linked muscular dystrophy" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | Transcription |
| Discussion Leader: Peter Rigby (The Institute of Cancer Research) |
| 5:30 pm - 5:50 pm | Richard Harvey (Victor Chang Cardiac Research Institute)
"Coordination of multiple roles of Bmp in cardiogenesis" |
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:15 pm | Anthony Imbalzano (University of Massachusetts Medical School)
"Regulation of myogenic late gene expression" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:40 pm | Vittorio Sartorelli (National Institutes of Health)
"Effectors of caloric restriction in skeletal muscle cells" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Annick Harel-Bellan (Institut Andre Lwoff)
"Micro-RNA pathways and myoblast differentiation" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Dylan Sweetman (University of East Anglia)
"Micro RNAs in myogenesis" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regeneration |
| Discussion Leader: Terry Partridge (Childrens National Medical Center) |
| 9:00 am - 9:20 am | Michael Rudnicki (Ottowa Hospital Research Institute)
"Pax7 and the molecular regulation of myogenic stem cell function" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Graciella Unguez (New Mexico State University)
"Activation of Pax7 myogenic cells in tail regeneration of electric fish" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Helen Blau (Stanford University)
"Artificial niches for high-throughput dynamic analyses of single adult stem cells" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Chad Cowan (Harvard Stem Cell Institute)
"Human embryonic stem cells: new tools for understanding muscle development and disease" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Brad Olwin (University of Colorado)
"A subpopulation of satellite cells engrafts into the satellite cell niche during muscle regeneration" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Giulio Cossu (Stem Cell Research Institute)
"Towards a clinical trial with stem cells in Duchenne muscular dystrophy" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Peter Zammit (King's College London)
"Molecular landmarks of satellite cell activation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Dawn Cornelison (University of Missouri)
"Phosphoproteomic comparison of proliferating vs differentiating myoblasts" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session III |
| 5:30 pm - 7:30 pm | Systems Biology |
| Discussion Leader: Barbara Wold (California Institute of Technology) |
| 5:30 pm - 5:50 pm | Alan Michelson (National Institutes of Health)
"An integrated approach to genetic regulatory networks in Drosophila muscle development" |
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:15 pm | Eileen Furlong (EMBO-Heidelberg)
"A systematic approach to dissecting transcriptional networks during Drosophila myogenesis" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:40 pm | Brian Dynlacht (NYU School of Medicine)
"Transcriptional control of myogenesis" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Peter A.C. 't Hoen (Leiden University Medical Center)
"A comprehensive meta-analysis of microarray studies on muscle development and disease aided by automated literature-based gene annotation" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Krzysztof Jagla (INSERM)
"Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling and Plasticity |
| Discussion Leader: Leslie Leinwand (University of Colorado) |
| 9:00 am - 9:20 am | Nadia Rosenthal (EMBL-Monterotondo)
"Signaling in muscle regeneration" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Steve Burden (Skirball Institute)
"The role of muscle pre-patterning in dictating where motor axons grow and form synapses" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Ravi Kambadur (AgResearch)
"Myostatin signaling during postnatal muscle growth" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Pura Munoz-Canoves (Center for Genomic Regulation)
"Regulation of myogenesis by p38 MAP kinases" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | John McDermott (York University)
"Post-transcriptional regulation of MEF2 activity" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Eyal Bengal (Technion Medical School)
"CREB functions downstream of a Wnt/FGF pathway in the regulation of mesoderm identity and myogenesis" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | David Glass (Novartis Institute for Biomedical Research)
"Signaling pathways that mediate skeletal muscle atrophy and hypertrophy" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 5:30 pm - 7:30 pm | Muscle, Cancer, and Differentiation |
| Discussion Leader: Nadia Rosenthal (EMBL-Monterotondo) |
| 5:30 pm - 5:50 pm | David Sassoon (INSERM-Paris)
"Muscle-tumor interactions and hidden stem cells" |
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:15 pm | Lorenzo Puri (Dulbecco Telethon Institute)
"Signal-dependent changes of chromatin in myogenic progenitors during muscle regeneration" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:40 pm | Jeffrey Dilworth (Ottawa Health Research Institute)
"Phosphorylation of Mef2D by p38 recruits the Ash2L complex to specific genes to epigenetically mark them for high levels of expression during myogenesis" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Charles Emerson (Boston Biomedical Research Institute)
"Hedgehog (HH) signaling and the stem cell origins of rhabdomyosarcoma" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:20 pm | Nikki Harter (Case Western Reserve University)
"A functional role for MyoD in licensing origins of DNA replication in activated satellite cells" |
| 7:20 pm - 7:25 pm | Discussion |
| 7:25 pm - 7:30 pm | Final Comments |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
