SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lectures |
| Discussion Leader: Gabrielle Kardon (University of Utah, USA) |
7:40 pm - 8:40 pm | Cliff Tabin (Harvard University, USA)
"Smooth muscle differentiation and radial morphogenesis of the gut"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Peter Rigby (The Institute of Cancer Research, London, UK)
"Reflections on the Future"
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9:15 pm - 9:30 pm | Discussion |
9:30 pm | Opening Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Muscle Cell Biology and Myofiber Formation |
| Discussion Leader: Leslie Leinwand (University of Colorado at Boulder, USA) |
9:00 am - 9:20 am | Susan Abmayr (Stowers Institute for Medical Research, USA)
"Myoblast Fusion in Drosophila: Mechanistic insights from live imaging"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Elizabeth Chen (Johns Hopkins University School of Medicine, USA)
"A critical role of actin-propelled membrane protrusions in cell-cell fusion"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Mary Baylies (Sloan-Kettering Institute, USA)
"How Motors build Muscles"
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10:10 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Group Photo / Coffee Break |
10:35 am - 10:55 am | Grace Pavlath (Emory University, USA)
"Nuclear transport pathways during muscle differentiation"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Talila Volk (Weizmann Institute of Science, Israel)
"Mechanisms promoting robust distribution of organelles in contracting muscle" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Frank Schnorrer (Max Planck Institute of Biochemistry, Germany)
"Forces control myofibrillogenesis in Drosophila flight muscle"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Tom Rando (Stanford University, USA)
"Molecular regulation of muscle stem cell quiescence and activation"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Aurore L'Honore (Institut Pasteur)
"Pitx2 and Pitx3 play a critical role in resetting redox metabolic rates during the transition from myogenic progenitor to differentiated muscle cell"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Evolutionary and Developmental Origin of Muscle |
| Discussion Leader: Peter Currie Australian Regenerative Medicine Institute, Australia) |
5:30 pm - 5:50 pm | Ullrich Technau (University of Vienna, Austria)
"Evolution of triploblasty and muscles: insights from the diploblastic cnidarian"
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5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:15 pm | Olivier Pourquié (CNRS, University of Strasbourg, France)
"Making muscle in vitro"
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6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Christophe Marcelle (Australian Regenerative Medicine Institute, Australia)
"Muscle fusion in the chick embryo"
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6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Eldad Tzahor (Weizmann Institute of Science, Israel)
"ERK nuclear shuttling as a nodal step in the regulation of head myogenesis"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Short Talk: Lionel Christiaen (New York University, USA)
"The origins of the second heart field and head muscle stem cells"
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7:20 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem Cells and Regeneration |
| Discussion Leader: Carmen Birchmeier (Max Delbrueck Centre for Molecular Medicine, Berlin, Germany) |
9:00 am - 9:20 am | Helen Blau (Stanford University School of Medicine, USA)
"Reprogramming Stem Cell Fate" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Dawn Cornelison (University of Missouri, USA)
"Puzzling out a pattern: Eph/ephrin regulation of muscle fibre type in the adult"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Shahragim Tajbakhsh (Pasteur Institute, France)
"Signaling and molecular regulation of skeletal muscle stem cells"
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10:10 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Coffee Break |
10:35 am - 10:55 am | Michael Rudnicki (Ottawa Hospital Research Institute, Canada)
"Molecular Regulation of Muscle Stem Cell Function"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Thomas Braun (Max Planck Institute for Heart and Lunch Research, Germany)
"Molecular circuits controlling muscle stem cell proliferation, maintenance and migration"
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11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Andrew Brack (Harvard University, MGH CRM, USA)
"Satellite cell heterogeneity during stress and repair"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | David Glass (Novartis Institutes for Biomedical Research, USA)
"Mediators of activation and differentiation of satellite cells perturbed in rhabdomyosarcoma"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Dominique Broehl (Max Delbrueck Centre for Molecular Medicine)
"Colonization of the Satellite Cell Niche by Skeletal Muscle Progenitor Cells Depends on Notch Signals"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Transcription and Epigenetics: Cell Autonomous Effectors of the Muscle Cell |
| Discussion Leader: Peter Rigby (The Institute of Cancer Research, London) |
5:30 pm - 5:50 pm | Steve Tapscott (Fred Hutchinson Cancer Research Center, USA)
"Molecular determinants of muscle gene transcription by bHLH proteins"
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5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:15 pm | Pascal Maire (University Paris Descartes, France)
"Regulation of muscle cell state by Six homeoproteins"
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6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Lorenzo Puri (Sanford-Burnham Medical Research Institute, USA)
"Epigenetic Network Regulating Skeletal Myogenesis in Stem Cells"
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6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Vittorio Sartorelli (NIAMS, National Institute of Health, USA)
"Chromatin Interactors Shape the Muscle Epigenome"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Short Talk: Andrea Munsterberg (University of East Anglia, UK)
"MicroRNA mediated regulation of BAF chromatin remodeling factors in embryo myogenesis"
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7:20 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Muscle Interactions |
| Discussion Leader: Mary Baylies (Sloan-Kettering Institute, USA) |
9:00 am - 9:20 am | Tom Schilling (University of California, USA)
"Thrombospondins as critical components of extracellular matrix organization at myotendinous junctions"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Delphine Duprez (Universite Pierre Et Marie Curie, France)
"Transcription and growth factors during tendon formation and repair"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Eli Zelzer (Weizmann Institute of Science, Israel)
"The development of Tendon-Bone Attachment Unit" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Coffee Break |
10:35 am - 10:55 am | Fabio Rossi (University of British Columbia, Canada)
"Crosstalk between innate immune cells and mesenchymal progenitors regulates the balance between regeneration and degeneration in skeletal muscle"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Rob Krauss (Mount Sinai School of Medicine, USA)
"Skeletal and smooth muscle patterning during esophageal morphogenesis"
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11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Steve Burden (NYU Langone Medical Center and School of Medicine, USA)
"Tendon cells provide a border to restrict muscle growth" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Krzysztof Jagla (University of Clermont-Ferrand, France)
"Filling the gaps in myogenic pathway: new insights from Drosophila"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Jeffery Dilworth (Ottawa Hospital Research Institute, Canada)
"Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Muscle Disease and Treatments |
| Discussion Leader: Stephen Tapscott (Fred Hutchinson Cancer Research Center, USA) |
5:30 pm - 5:50 pm | Giulio Cossu (University College London, United Kingdom)
"Cell therapy for muscular dystrophies"
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5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:15 pm | Graziella Messina (Universita Di Milano, Italy)
"Nfix in skeletal muscle regeneration: slow twitching fibers, slow regeneration and slower progression of the Dystrophic phenotype"
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6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Leslie Leinwand (University of Colorado at Boulder, USA)
"Myosin myopathies and mechanisms of pathogenesis"
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6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Davide Gabellini (San Raffaele Scientific Institute, Italy)
"FSHD muscular dystrophy: molecular mechanism and prospects for therapy"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Short Talk: Colin Crist (McGill University, Canada)
"Post transcriptional mechanisms regulating skeletal muscle stem cell activity"
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7:20 pm - 7:25 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Muscle Growth, Homeostasis, and Aging |
| Discussion Leader: Michael Rudnicki (Ottawa Hospital Research Institute, Canada) |
9:00 am - 9:20 am | Norbert Perrimon (Harvard Medical School, USA)
"Autonomous and non-autonomous factors regulating muscle growth and homeostasis in Drosophila"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Simon Hughes (King's College, London, UK)
"Muscle activity promotes growth through translational control of specific mRNAs"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | David Sassoon (University of Pierre and Marie Curie Paris VI, France)
"Integration of cell stress pathways and stem cell function - an emerging role for parentally imprinted genes"
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10:10 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Coffee Break |
10:35 am - 10:55 am | Charlotte Petersen (University of Kentucky, USA)
"New role for satellite cells in muscle adaptation"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Christophe Lepper (Carnegie Institution for Science, USA)
"Age-Dependent Genetic Regulation of Skeletal Muscle Stem Cells"
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11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Pura Munoz-Canovs (Universitat Pompeu Fabra, Spain)
"Regulation of satellite cell functions in aging"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Brad Olwin (University of Colorado at Boulder, USA)
"FGF Signaling Rescues a Cell-Autonomous Loss of Self-Renewal in Aged Skeletal Muscle Stem Cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Jaime Carvajal (Centro Andaluz de Biologia del Desarrollo, Spain)
"The regulation and function of Mrf4 and Myf5"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Muscle and Cancer |
| Discussion Leader: Giulio Cossu (University College London, UK) |
5:30 pm - 5:50 pm | Rene Galindo (University of Texas Southwestern Medical Center, USA)
"Genetic screening against a Drosophila model reveals new Rhabdomyosarcoma pathogenesis genes and mechanisms"
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5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:15 pm | David Langenau (Harvard Stem Cell Institute, USA)
"Fishing for Self-renewal Mechanisms in Rhabdomyosarcoma"
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6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Fredric Relaix (University Pierre Et Marie Curie Paris VI, France)
"Conserved and divergent Pax3/Pax7 functions during development, myogenesis and cancer"
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6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Michael Dyer (St. Jude's Children's Research Hospital, USA)
"Rhabdomyosarcoma: Bridging Developmental Biology and Cancer Genetics"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Denis Guttridge (Ohio State University, USA)
"Mechanisms of muscle wasting in cancer: looking outside the fiber"
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7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |