Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Muscle: From Snakes to Humans |
| Discussion Leader: Helen Blau (Stanford University, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:35 pm | Giulio Cossu (University of Manchester, United Kingdom) "Cell Therapy for Muscular Dystrophy: Lessons Learned and the Road to Efficacy" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Development of Muscle |
| Discussion Leader: Gabrielle Kardon (University of Utah, USA) |
9:00 am - 9:20 am | Christophe Marcelle (Monash University, Australia) "A Signaling Module Intimately Associates the Initiation of Myogenesis
to a Change in Cell Adhesion in Early Chick Development" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Clarissa Henry (University of Maine, USA) "Cell Adhesion in Muscle Development" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Shahragim Tajbakhsh (Institut Pasteur, France) "Genetic and Cellular Determinants of Skeletal Muscle Fate" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Selected from Poster Abstracts: Zhenguo Wu (Hong Kong University of Science and Technology, Hong Kong SAR China) "A Molecular Switch that Regulates the Cell Fate Choice Between Muscle Progenitor Cells and Brown Adipocytes" |
10:25 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Christoph Lepper (Carnegie Institution for Science, USA) "New Tools for Temporally-Controlled Genetic Manipulation of the Myogenic Cell Lineage" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Simon Hughes (King's College London, United Kingdom) "Homeostasis by Muscle Stem Cells Regulates Embryonic Muscle Size" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Peter Currie (Monash University, Australia) "Cellular and Molecular Mechanisms for Post Embryonic Muscle Growth and Regeneration in Zebrafish" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Dawn Cornelison (University of Missouri, USA) "Who Are You Calling Repulsive? Eph/Ephrin Signaling in Muscle Patterning" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Cellular Interactions in Development of Muscle |
| Discussion Leader: Peter Currie (Monash University, Australia) |
6:00 pm - 6:20 pm | Dennis Discher (University of Pennsylvania, USA) "From Matrix Mechanics to the Nuclear Lamina in
Striated Muscle Development and Disease" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:45 pm | Elazar Zelzer (Weizmann Institute of Science, Israel) "Muscle-Induced Mechanical Loads Regulate Key Aspects of Skeletogenesis and Regeneration" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Ronen Schweitzer (Portland Shriners Hospital, USA) "Regulation of Musculoskeletal Integration and Tendon Elongation" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Selected from Poster Abstracts: Peleg Hasson (Technion - Israel Institute of Technology, Israel) "Lysyl-Oxidase-Like 3 Regulation of Muscle and Muscle-Tendon Junction Development" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Steven Burden (New York University, USA) "Signaling Back and Forth Between Muscle and Nerve" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Cellular Interactions in Adult Muscle Regeneration |
| Discussion Leader: Bradley Olwin (University of Colorado, Boulder, USA) |
9:00 am - 9:20 am | Grace Pavlath (Emory University, USA) "Satellite Cells in Non-Limb Muscles" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:35 am | Selected from Poster Abstracts: Ning Liu (University of Texas Southwestern Medical Center, USA) "A Twist2-Dependent Myogenic Progenitor Cell Lineage Contributes to Skeletal Muscle Homeostasis and Regeneration" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:00 am | David Sassoon (Universite de Pierre et Marie Curie, France) "Niche Signals Leading to an Integrated Regenerative Response in Skeletal Muscle" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Selected from Poster Abstracts: Alessandra Sacco (Sanford-Burnham Medical Research Institute, USA) "Autonomous Niche Remodeling Controls Fetal Muscle Stem Cell Fate" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Daniela Rebolledo (Pontifical Catholic University of Chile, Chile) "Dual Role of HIF-1a in Damaged Skeletal Muscle: Inducer of Angiogenesis" |
10:30 am - 10:35 am | Discussion |
10:35 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Benedicte Chazaud (Universite Claude Bernard Lyon 1, France) "Molecular Coupling Between Myogenesis and Angiogenesis During Skeletal Muscle Regeneration" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Fabio Rossi (University of British Columbia, Canada) "Key Role of the Inflammatory Milieu in the Development of Fibrofatty Infiltration" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Selected from Poster Abstracts: Christopher Mendias (University of Michigan, USA) "Changes in Extracellular Matrix Production and Fibroblast Activity Precede Functional Myofiber Adaptations During Skeletal Muscle Hypertrophy" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | James Tidball (University of California, Los Angeles, USA) "Regulatory Interactions Between Myeloid Cells and Muscle During Disease
and Aging" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Joe Chakkalakal (University of Rochester, USA) "A Requirement for Skeletal Muscle Stem Cells in the Regeneration of Neuromuscular Synapses" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Muscle Fiber Type Specification and Metabolism |
| Discussion Leader: Denis Guttridge (The Ohio State University, USA) |
6:00 pm - 6:20 pm | Frank Schnorrer (Max Planck Institute of Biochemistry, Germany) "Building Flight Muscle - One Splice at a Time" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:45 pm | Zoltan Arany (University of Pennsylvania, USA) "Novel Mechanisms of Insulin Resistance in Skeletal Muscle" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Carlos Moraes (University of Miami, USA) "Therapeutic Approaches to Mitochondrial Defects in Muscle" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:35 pm | Markus Ruegg (University of Basel, Switzerland) "Activation of mTORC1 in Skeletal Muscle Affects Whole-Body Metabolism via the Release of FGF21" |
7:35 pm - 7:40 pm | Discussion |
7:40 pm - 7:50 pm | Selected from Poster Abstracts: Aaron Beedle (University of Georgia, USA) "Evidence for Alpha-Dystroglycan Function in Myogenesis and Muscle Regeneration: Lessons from Fktn-Deficient Dystroglycanopathy Mice" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Role of Transcription, Epigenetics, and Non-Coding RNAs in Myogenesis |
| Discussion Leader: Michael Rudnicki (Ottawa Hospital Research Institute, Canada) |
9:00 am - 9:20 am | Stephen Tapscott (Fred Hutchinson Cancer Research Center, USA) "The Regulation of Gene Expression in Normal Muscle Development and Disease" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:35 am | Selected from Poster Abstracts: Jaime Carvajal (Centro Andaluz de BiologĂa del Desarrollo, Spain) "3D Chromatin Structure and Transcriptional Regulation in the Mrf4/Myf5 Locus" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Colin Crist (McGill University, Canada) "Phosphorylation of eIF2(alpha) Regulates Quiescence and Self-Renewal of Skeletal Muscle Stem Cells" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Graziella Messina (University of Milan, Italy) "Driving Towards Fetal Myogenesis:
Nfix Induces a Switch in Sox6 Transcriptional Activity Required for Fetal Muscle Fiber Specification" |
10:25 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Huating Wang (The Chinese University of Hong Kong, Hong Kong SAR China) "Functional Study of Long Non-Coding RNAs in Skeletal Muscle Cells" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Jeffrey Dilworth (Ottawa Hospital Research Institute, Canada) "Trithorax Proteins as Epigenetic Regulators of Cell Fate Transitions During Muscle Regeneration" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Lorenzo Puri (Sanford-Burnham Medical Research Institute, USA) "Epigenetic Control of Skeletal Myogenesis in Health and Disease" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Vittorio Sartorelli (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA) "Epigenetics of Skeletal Muscle Transcription" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Muscle Cell Biology |
| Discussion Leader: Shahragim Tajbakhsh (Institut Pasteur, France) |
6:00 pm - 6:20 pm | Mary Baylies (Memorial Sloan Kettering Cancer Center, USA) "MAPs, Motors and Signals Drive Myonuclear Positioning and Muscle Function" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:45 pm | Elizabeth Chen (Johns Hopkins University, USA) "Mechanical Tension Drives Myoblast Fusion" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Douglas Millay (Cincinnati Children's Hospital Medical Center, USA) "Regulation of Myomaker Function" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:35 pm | Talila Volk (Weizmann Institute of Science, Israel) "The Biology of Muscle Nuclei" |
7:35 pm - 7:40 pm | Discussion |
7:40 pm - 7:50 pm | Selected from Poster Abstracts: Jinmo Gu (The Ohio State University, USA) "NF-kB Dependent Communication Between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Muscle Stem Cells and Regeneration |
| Discussion Leader: Pura Munoz-Canoves (Universitat Pompeu Fabra and ICREA, Spain) |
9:00 am - 9:20 am | Helen Blau (Stanford University, USA) "Regulation of Muscle Stem Cell Fate and Function" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | David Goldhamer (University of Connecticut, USA) "MRF-Dependent Muscle Stem Cell Programming" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Thomas Braun (Max Planck Institute for Heart and Lung Research, Germany) "Epigenetic Regulation of Muscle Stem Cell Quiescence and Proliferation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Robert Krauss (Icahn School of Medicine at Mount Sinai, USA) "Regulation of Satellite Cell Quiescence by Classical Cadherins" |
10:35 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Frederic Relaix (Universite de Pierre et Marie Curie, France) "Transcriptomic Chronology of Skeletal Muscle Stem Cells Identifies SoxF Genes as Regulators of Satellite Cell Renewal via Interaction with b-Catenin" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Selected from Poster Abstracts: Fabien Le Grand (Centre de Recherche en Myologie, France) "Canonical Wnt Signalling Regulates Nuclear Export of Setdb1 During Skeletal Muscle Terminal Differentiation" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Michael Rudnicki (Ottawa Hospital Research Institute, Canada) "Molecular Regulation of Satellite Cell Asymmetric Division" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Bradley Olwin (University of Colorado, Boulder, USA) "Regulating Muscle Stem Cell Homeostasis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Muscle Growth, Homeostasis, and Sarcopenia |
| Discussion Leader: Grace Pavlath (Emory University, USA) |
6:00 pm - 6:20 pm | Pura Munoz-Canoves (Universitat Pompeu Fabra and ICREA, Spain) "Muscle Stem Cell Decline in Aging" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:35 pm | Selected from Poster Abstracts: Michelle Rozo (Carnegie Institute of Embryology, USA) "Coordination of ß1-Integrin and FGF Drives the Muscle Stem Cell During Aging" |
6:35 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Fabio Demontis (St. Jude Children's Research Hospital, USA) "Skeletal Muscle Aging and Myokine Signaling in Drosophila" |
7:00 pm - 7:05 pm | Discussion |
7:05 pm - 7:25 pm | David Glass (Novartis Institutes for Biomedical Research, USA) "Maintenance and Modulation of Muscle's Mass and Mission" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Russell Hepple (Research Institute of the McGill University Health Centre (RI-MUHC), Canada) "Mechanisms of Denervation in Aging Muscle" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |