Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Signaling Networks in Skeletal Myogenesis
Discussion Leader: Marco Sandri (University of Padova, Italy)
7:40 pm - 8:30 pm
Stefano Schiaffino (Venetian Institute of Molecular Medicine (VIMM), Italy)
"Winding Paths in Muscle Research: A Personal Retrospective"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Shenhav Cohen (Technion - Israel Institute of Technology, Israel)
"Native Heteromultimeres of Plakoglobin, Insulin Receptors and Dystrophin Glycoprotein Complex Regulate Muscle Size"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Arunima Murgai (Freie Universitaet Berlin, Germany)
"Noggin Is Essential for Maintaining Myogenic Cell-Fate and Directing Differentiation and Fusion During Fetal Myogenesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Growth
Discussion Leader: Christophe Marcelle (Université Claude Bernard Lyon 1, France)
9:00 am - 9:20 am
Shahragim Tajbakhsh (Institut Pasteur, France)
"Distinct Genetic Pathways Direct Cranial and Somite Derived Skeletal Muscles"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Thomas Braun (Max-Planck-Institute for Heart and Lung Research, Germany)
"Manipulation of Epigenetic Pathways in Muscle Stem Cells to Improve Skeletal Muscle Disorders"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Eldad Tzahor (Weizmann Institute of Science, Israel)
"Novel Strategies for Cardiac Regeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Fabien Le Grand (Universite Pierre et Marie Curie, France)
"Discovery and Functional Profiling of Novel Muscle Cell Populations with Mass Cytometry Single-Cell Proteomics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Peter Currie (Australian Regenerative Medicine Institute, Australia)
"Defining the Genetics of Muscle Fiber Assembly in the Zebrafish Myotome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Thomas Rando (Stanford University, USA)
"Molecular Regulation of Satellite Cell Quiescence and Activation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell Fusion
Discussion Leader: Gabrielle Kardon (University of Utah, USA)
6:00 pm - 6:20 pm
Elizabeth Chen (University of Texas Southwestern Medical Center, USA)
"Spectrin: A Dynamic Mechanosensing Molecule at the Fusogenic Synapse"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Christophe Marcelle (Université Claude Bernard Lyon 1, France)
"A Bird's-Eye View on Muscle Fusion"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Florian Bentzinger (University of Sherbrooke, Canada)
"Extrinsic Regulation of Muscle Stem Cell Specification"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Douglas Millay (Cincinnati Children's Hospital Medical Center, USA)
"Myoblast Fusion: Novel Genes and Significance During Muscle Growth and Homeostasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Regeneration and Muscle Stem Cells
Discussion Leader: Andrew Brack (University of California, San Francisco, USA)
9:00 am - 9:20 am
Alessandra Sacco (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Dynamics of Muscle Stem Cell Expansion During Tissue Repair and Maintenance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Michael Rudnicki (Ottawa Hospital Research Institute, Canada)
"Molecular Regulation of Muscle Stem Cell Asymmetric Division"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Frederic Relaix (Université Paris-Est Créteil Val-de-Marne, France)
"Molecular Mechanisms Regulating Satellite Cells Quiescence and Activation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Colin Crist (McGill University, Canada)
"Translation Control of Muscle Stem Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Helen Blau (Stanford University, USA)
"Regulators of Muscle Stem Cell Fate and Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Jerome Feige (Nestlé Institute of Health Science, EPFL, Switzerland)
"Aging Impairs the Function of Fibro-Adiopogenic Progenitors During Muscle Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Srihari Sampath (Genomics Institute of the Novartis Research Foundation, USA)
"The Microprotein Minion Controls Cell Fusion and Muscle Formation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Muscle/Stroma Interactions
Discussion Leader: Benedicte Chazaud (Universite Claude Bernard Lyon 1, France)
6:00 pm - 6:20 pm
Fabio Rossi (University of British Columbia, Canada)
"A Role for Stroma in Muscle Homeostasis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Richard Lieber (Rehabilitation Institute of Chicago, USA)
"Biomechanical and Structural Insights into Skeletal Muscle Fibrosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Gabrielle Kardon (University of Utah, USA)
"The Role of Somatic Mutations in Development of a Common Birth Defect, Congenital Diaphragmatic Hernias"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Andrew Brack (University of California, San Francisco, USA)
"Adult Muscle Stem Cell Dormacy and the Niche"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Muscle Metabolism: Energy Regulation and Muscle Fiber Type
Discussion Leader: Shahragim Tajbakhsh (Institut Pasteur, France)
9:00 am - 9:20 am
David Glass (Novartis Institutes for Biomedical Research, USA)
"Mediators of Skeletal Muscle Mass and Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Zoltan Arany (University of Pennsylvania, USA)
"Muscle Metabolism: The Vasculature Matters Too"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Remi Mounier (Universite de Lyon, France)
"Cell- and Non-Cell-Autonomous Metabolic Regulations of Muscle Stem Cell Fate and Skeletal Muscle Homeostasis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Chan (California Institute of Technology, USA)
"Mitochondrial Dynamics and Metabolism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mary Baylies (Memorial Sloan Kettering Cancer Center, USA)
"Mechanisms Regulating Muscle Cell Size"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Vincent Gache (Institut NeuroMyoGène, INSERM, France)
"Myonuclear Domains Establishment in Skeletal Muscle Fibers Formation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Chi Bun Chan (The University of Hong Kong, Hong Kong SAR China)
"Role of Muscle-Derived BDNF in Metabolic Flexibility"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Muscle Remodeling: Hypertrophy and Sarcopenia
Discussion Leader: Denis Guttridge (Ohio State University, USA)
6:00 pm - 6:20 pm
Bradley Olwin (University of Colorado, USA)
"Non Cell Autonomous Regulation of Satellite Cell Self-Renewal During Muscle Regeneration"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Pura Munoz-Canoves (Spanish National Cardiovascular Research Centre (CNIC), Spain)
"Understanding Muscle Stem Cell Regenerative Decline with Aging"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Marco Sandri (University of Padova, Italy)
"Insights of the Exercise-Mediated Muscle Remodelling"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Paul Gregorovic (Baker Heart and Diabetes Institute, Australia)
"Exploring New Roles for the TGFb Network in the Regulation of Muscle Mass"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Transcription/Epigenetics of the Myogenic Program
Discussion Leader: Pura Munoz-Canoves (Spanish National Cardiovascular Research Centre (CNIC), Spain)
9:00 am - 9:10 am
Selected from Poster Abstracts: Sigmar Stricker (Freie Universitaet Berlin, Germany)
"Odd Skipped-Related 1 (Osr1) Identifies Embryonic Fibro-Adipogenic Progenitors (FAPs) and Regulates a Pro-Myogenic Transcriptional Program During Limb Development"
9:10 am - 9:15 am
Discussion
9:15 am - 9:35 am
Vittorio Sartorelli (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"Epigenetics of Skeletal Myogenesis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Stephen Tapscott (Fred Hutchinson Cancer Research Center, USA)
"DUX4 and the Pathophysiology of FSHD"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Anthony Imbalzano (University of Massachusetts Medical School, USA)
"Signaling to Chromatin: Balancing Myoblast Proliferation and Differentiation"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Jeffrey Dilworth (University of Ottawa, Canada)
"Enzyme Dependent and Independent Roles for Epigenetic Factors in Determining Muscle Stem Cell Fates"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Jozef Dulak (Jagiellonian University, Poland)
"Heme Oxygenase-1 Delays Progression of Duchenne Muscular Dystrophy in Mice and Influences Satellite Cells Differentiation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Peter Zammit (King's College London, United Kingdom)
"Pax7 Target Genes Are Repressed in Facioscapulohumeral Muscular Dystrophy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neuromuscular Disorders: Basic Mechanisms
Discussion Leader: Thomas Braun (Max-Planck-Institute for Heart and Lung Research, Germany)
6:00 pm - 6:20 pm
Steven Burden (New York University, USA)
"Forming and Maintaining Neuromuscular Synapses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Lorenzo Puri (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Cellular and Epigenetic Determinants of Pathogenesis and Progression of Neuromuscular Disorders"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jocelyn Laporte (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France)
"Molecular and Physiological Bases of Centronuclear Myopathies, and Epistasis Regulation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Andrea Graziani (Vita-Salute San Raffaele University, Italy)
"Ghrelin Regulates Satellite Cell Dynamics and Improves Dystrophic Pathology in Mdx Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure