Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Skeletal Muscle Development: New Perspectives
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:40 pm
"Mixing and Matching Developmental and Regenerative Myogenesis"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Molecular Profiling of Human Sarcopenia Across Ethnicities"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Dynamic Muscle Precursor Cell Movements in Zebrafish Require Six-Family Genes"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Complexity of Skeletal Muscle Architecture
9:00 am - 9:20 am
"Cancer, Bone, Muscle and Metabolism: What's the Connection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cell-Cell Interactions Regulating Muscle Adaptation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Endothelial Pfkfb3 Controls Muscle Regeneration by Instructing a Lactate Mediated Switch in Macrophage Polarization"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Force-Mediated Coupling of Muscle Stem Cell Proliferation and Differentiation During Regeneration"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Myonuclei Organization in Mature Muscle Fibers: Controlling Muscle Behavior"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Regulation of Nuclear Size, Position and Activity in the Muscle Fiber"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Building and Maintaining Skeletal Muscle: Activity and Metabolism
6:00 pm - 6:20 pm
"Novel Players in Muscle Wasting and in Metabolic Adaptation to Exercise"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Metabolic Regulations of Adult Muscle Stem Cell Fate"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"A Novel Link Between the Ubiquitin Proteasome System and Mitochondrial Function to Control Muscle Metabolism"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Splicing Factor Scaf6/CHERP Regulates Muscle Development in Drosophila "
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Metabolic Defects Promote Muscle Degeneration in a Muscular Dystrophy Model"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular and Molecular Mechanisms of Muscular Diseases
9:00 am - 9:20 am
"High Level of Dystrophin Produced by Trans-Correction of Resident Nuclei upon Fusion of Myogenic Cells Expressing U7 snRNA to Skip Exon 51"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Pathomechanisms and Therapies for the Muscular Dystrophies"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Extracellular Matrix Environment in DMD Impairs Stem Cell Function"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"PAX7, DUX4 and Facioscapulohumeral Muscular Dystrophy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Collagen VI Deficiency: Mechanisms and New Gene and Transcript Directed Therapeutic Strategies"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"NF-κB Function in the Muscle Microenvironment Controlling Cancer Cachexia"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Building and Maintaining Skeletal Muscle: Muscle Homeostasis
6:00 pm - 6:20 pm
"Mechanisms of Skeletal Muscle Aging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"TGFβ Signaling Curbs Cell Fusion and Muscle Regeneration"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The BTB-Zinc Finger Fallen Angel Regulates a Transcriptional Switch During Mid-Muscle Development Instructing Sarcomere Maturation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Mechanisms of Activity-Dependent Muscle Growth"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic, Transcriptional and Post-Transcriptional Regulation of Myogenesis
9:00 am - 9:20 am
"Epigenetics of Skeletal Myogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Polycomb Dysfunctional Transcriptional Repression Contributes to Lamin A/C Dependent Muscular Dystrophy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"RNA-Mediated Gene Expression Control in Myogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Pax3 Cooperates with Ldb1 to Direct Local Chromosome Architecture During Myogenic Lineage Specification"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Metabolism Regulates Muscle Stem Cell Self-Renewal by Connecting the Microenvironment and Histone Acetylation"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Regulation of DUX4 in FSHD Muscular Dystrophy"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intrinsic Signaling in Muscle Cells
6:00 pm - 6:20 pm
"Molecular Regulation of Stem Cell Quiescence"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Transcriptional Regulation of Muscle Diversity in Drosophila Embryos"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Hedgehog Signalling in the Control of Satellite Cell Activity and Muscle Regeneration"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Paxbp1 Is Indispensable in Adult Muscle Satellite Cells During Injury-Induced Muscle Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Extrinsic Regulation of the Muscle Microenvironments
9:00 am - 9:20 am
"Modulation of Regeneration by Stromal Signalling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Nfix and Macrophages in Acute and Chronic Muscle Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The 'Kairos' of Neutrophil Activity in Muscle Regeneration and Dystrophy"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Balancing ECM Modifications and Transcriptional Regulation During Muscle Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Signaling Surprises in Quiescent Muscle Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Exploring the Hippo Pathway as a Post-Natal Regulator of Skeletal Muscle"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Regulation of Satellite Cells by Niche Adherens Junctions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Satellite Cells and Regeneration
6:00 pm - 6:20 pm
"Molecular Regulation of Muscle Stem Cell Function"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Combinatorial Signalling Defines the Activation Network in Muscle Stem Cells"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"A Role of Twist2 in Physiological and Pathological Myogenesis"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration in Chronic Regenerative Disease"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Dynamics of Muscle Stem Cell Function During Tissue Growth and Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure