Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Skeletal Muscle Development: New Perspectives
Discussion Leader: Giulio Cossu (University of Manchester, United Kingdom)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:40 pm
Shahragim Tajbakhsh (Institut Pasteur, France)
"Mixing and Matching Developmental and Regenerative Myogenesis"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Jerome Feige (Nestlé Institute of Health Sciences, EPFL, Switzerland)
"Molecular Profiling of Human Sarcopenia Across Ethnicities"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Jared Talbot (Ohio State University, USA)
"Dynamic Muscle Precursor Cell Movements in Zebrafish Require Six-Family Genes"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Complexity of Skeletal Muscle Architecture
Discussion Leader: Nicolas Dumont (Université de Montréal, Canada)
9:00 am - 9:20 am
Theresa Guise (Indiana University, USA)
"Cancer, Bone, Muscle and Metabolism: What's the Connection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Charlotte Peterson (University of Kentucky, USA)
"Cell-Cell Interactions Regulating Muscle Adaptation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Katrien De Bock (ETH Zurich, Switzerland)
"Endothelial Pfkfb3 Controls Muscle Regeneration by Instructing a Lactate Mediated Switch in Macrophage Polarization"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Robert Knight (King's College London, United Kingdom)
"Force-Mediated Coupling of Muscle Stem Cell Proliferation and Differentiation During Regeneration"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Vincent Gache (Institut NeuroMyoGène / INSERM, France)
"Myonuclei Organization in Mature Muscle Fibers: Controlling Muscle Behavior"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Mary Baylies (Memorial Sloan Kettering Cancer Center, USA)
"Regulation of Nuclear Size, Position and Activity in the Muscle Fiber"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Clarissa Henry (University of Maine, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Building and Maintaining Skeletal Muscle: Activity and Metabolism
Discussion Leader: Cristina Mammucari (University of Padova, Italy)
6:00 pm - 6:20 pm
Marco Sandri (University of Padova, Italy)
"Novel Players in Muscle Wasting and in Metabolic Adaptation to Exercise"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Remi Mounier (Institut NeuroMyoGène / CNRS, France)
"Metabolic Regulations of Adult Muscle Stem Cell Fate"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Vanina Romanello (University of Padova, Italy)
"A Novel Link Between the Ubiquitin Proteasome System and Mitochondrial Function to Control Muscle Metabolism"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Maria Spletter (Ludwig-Maximilians-Universität München, Germany)
"Splicing Factor Scaf6/CHERP Regulates Muscle Development in Drosophila "
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Erika Geisbrecht (Kansas State University, USA)
"Metabolic Defects Promote Muscle Degeneration in a Muscular Dystrophy Model"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular and Molecular Mechanisms of Muscular Diseases
Discussion Leader: Marina Bouche (Sapienza University of Rome, Italy)
9:00 am - 9:20 am
Giulio Cossu (University of Manchester, United Kingdom)
"High Level of Dystrophin Produced by Trans-Correction of Resident Nuclei upon Fusion of Myogenic Cells Expressing U7 snRNA to Skip Exon 51"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Melissa Spencer (University of California, Los Angeles, USA)
"Pathomechanisms and Therapies for the Muscular Dystrophies"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rachelle Crosbie (University of California, Los Angeles, USA)
"The Extracellular Matrix Environment in DMD Impairs Stem Cell Function"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Peter Zammit (King's College London, United Kingdom)
"PAX7, DUX4 and Facioscapulohumeral Muscular Dystrophy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Carsten Bonnemann (National Institutes of Health, USA)
"Collagen VI Deficiency: Mechanisms and New Gene and Transcript Directed Therapeutic Strategies"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Denis Guttridge (Medical University of South Carolina, USA)
"NF-κB Function in the Muscle Microenvironment Controlling Cancer Cachexia"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Building and Maintaining Skeletal Muscle: Muscle Homeostasis
Discussion Leader: Ombretta Guardiola (Institute of Genetics and Biophysics, CNR, Italy)
6:00 pm - 6:20 pm
David Glass (Novartis Institutes for Biomedical Research, USA)
"Mechanisms of Skeletal Muscle Aging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Fabien Le Grand (Sorbonne Université, France)
"TGFβ Signaling Curbs Cell Fusion and Muscle Regeneration"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Frank Schnorrer (Developmental Biology Institute of Marseille (IBDM), France)
"The BTB-Zinc Finger Fallen Angel Regulates a Transcriptional Switch During Mid-Muscle Development Instructing Sarcomere Maturation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Simon Hughes (Medical Research Council / King's College London, United Kingdom)
"Mechanisms of Activity-Dependent Muscle Growth"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic, Transcriptional and Post-Transcriptional Regulation of Myogenesis
Discussion Leader: Monica Suelves (Institute for Health Science Research Germans Trias i Pujol (IGTP), Spain)
9:00 am - 9:20 am
Vittorio Sartorelli (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"Epigenetics of Skeletal Myogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Chiara Lanzuolo (Istituto Nazionale Genetica Molecolare / National Research Council (CNR), Italy)
"Polycomb Dysfunctional Transcriptional Repression Contributes to Lamin A/C Dependent Muscular Dystrophy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Irene Bozzoni (Sapienza University of Rome, Italy)
"RNA-Mediated Gene Expression Control in Myogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Alessandro Magli (University of Minnesota, USA)
"Pax3 Cooperates with Ldb1 to Direct Local Chromosome Architecture During Myogenic Lineage Specification"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
James Ryall (The University of Melbourne, Australia)
"Metabolism Regulates Muscle Stem Cell Self-Renewal by Connecting the Microenvironment and Histone Acetylation"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Davide Gabellini (San Raffaele Scientific Institute, Italy)
"Regulation of DUX4 in FSHD Muscular Dystrophy"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intrinsic Signaling in Muscle Cells
Discussion Leader: Carlos Aguilar (University of Michigan, USA)
6:00 pm - 6:20 pm
Thomas Rando (Stanford University, USA)
"Molecular Regulation of Stem Cell Quiescence"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Krzysztof Jagla (Genetics Reproduction & Development (GReD) Institute, France)
"Transcriptional Regulation of Muscle Diversity in Drosophila Embryos"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Anne-Gaelle Borycki (University of Sheffield, United Kingdom)
"Hedgehog Signalling in the Control of Satellite Cell Activity and Muscle Regeneration"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Zhenguo Wu (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Paxbp1 Is Indispensable in Adult Muscle Satellite Cells During Injury-Induced Muscle Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Extrinsic Regulation of the Muscle Microenvironments
Discussion Leader: Sigmar Stricker (Freie Universität Berlin, Germany)
9:00 am - 9:20 am
Fabio Rossi (University of British Columbia, Canada)
"Modulation of Regeneration by Stromal Signalling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Graziella Messina (University of Milan, Italy)
"Nfix and Macrophages in Acute and Chronic Muscle Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Dada Pisconti (Stony Brook University, USA)
"The 'Kairos' of Neutrophil Activity in Muscle Regeneration and Dystrophy"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Peleg Hasson (Technion - Israel Institute of Technology, Israel)
"Balancing ECM Modifications and Transcriptional Regulation During Muscle Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jyotsna Dhawan (Centre for Cellular and Molecular Biology, India)
"Signaling Surprises in Quiescent Muscle Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Paul Gregorevic (The University of Melbourne, Australia)
"Exploring the Hippo Pathway as a Post-Natal Regulator of Skeletal Muscle"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Robert Krauss (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Satellite Cells by Niche Adherens Junctions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Satellite Cells and Regeneration
Discussion Leader: Thomas Laumonier (Geneva University Hospitals and Faculty of Medicine, Switzerland)
6:00 pm - 6:20 pm
Michael Rudnicki (Ottawa Hospital Research Institute, Canada)
"Molecular Regulation of Muscle Stem Cell Function"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Philippos Mourikis (Mondor Institute of Biomedical Research (INSERM U955), France)
"Combinatorial Signalling Defines the Activation Network in Muscle Stem Cells"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Ning Liu (University of Texas Southwestern Medical Center, USA)
"A Role of Twist2 in Physiological and Pathological Myogenesis"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Johnny Kim (Max Planck Institute for Heart and Lung Research, Germany)
"Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration in Chronic Regenerative Disease"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Alessandra Sacco (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Dynamics of Muscle Stem Cell Function During Tissue Growth and Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure