Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Single Cell Transcriptomics
Discussion Leader: Stephen Tapscott (Fred Hutchinson Cancer Center, United States)
7:40 pm - 8:25 pm
Ibrahim Cisse (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Super-Resolution Imaging of Transcription in Live Mammalian Cells"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Erik Jacques (University of Toronto, Canada)
"The Silico Predictions Coupled with Mini-IDLE Identifies Myofiber-Derived Biomolecules Dictating Muscle Stem Cell Quiescence"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Thomas Rando (University of California, Los Angeles, United States)
"Metabolic and Epigenetic Regulation of Satellite Cell Quiescence"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Latest Advances in Understanding Muscle Development
Discussion Leader: Gabrielle Kardon (University of Utah, United States)
9:00 am - 9:20 am
Peter Currie (Australian Regenerative Medicine Institute, Australia)
"The Regulation of Muscle Stem Cell Formation and Action During Developmental Growth and Regeneration in the Zebrafish Myotome"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Talila Volk (Professor at the Weizmann Institute of Science, Israel)
"The LINC Complex Inhibits Excessive Chromatin Repression in Muscle Fibers"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Maria Spletter (University of Missouri Kansas City, United States)
"Bruno 1 Regulates Cytoskeletal Assembly and a Temporal Splicing Transition to Promote Sarcomere Growth and Maturation in Drosophila Flight Muscle"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Krzysztof Jagla (GReD Institute, INSERM 1103, CNRS 6293, University of Clermont Auvergne, France)
"Acquisition of Muscle Identity: Matter of Space and Time"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Erika Geisbrecht (Kansas State University, United States)
"Dysregulation of Autophagy and the Impact on Skeletal Muscle Proteostasis"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Aaron Johnson (Washington University School of Med, United States)
"Infection and Chronic Disease Activate a Brain-Muscle Signaling Axis that Regulates Muscle Performance"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Simon Hughes (Medical Research Council / King's College London, United Kingdom)
"Circadian and Activity Drivers of Muscle Growth: Breaking the Circle"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Clarissa Henry (University of Maine, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intrinsic and Extrinsic Factor Controlling Satellite Cell Function
Discussion Leader: Carmen Birchmeier (Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany)
6:00 pm - 6:20 pm
David Glass (Regeneron Pharmaceuticals, United States)
"Mechanisms Governing Skeletal Muscle Aging and Function"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Elena Ruggieri (Ospedale San Raffaele srl, Italy)
"High Mobility Group Box 1 Recycling Orchestrates Regeneration in Skeletal Muscle"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Shihuan Kuang (Purdue University, United States)
"A Mitochondrial Protein Regulates Cytosolic Protein Synthesis and Muscle Growth"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Brendan Evano (Institut Pasteur, France)
"Dynamics of Muscle Stem Cell Divisions: Insights from Static and Live Imaging"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Zachary Hettinger (Harvard Medical School, United States)
"Loss of the Primordial Muscle Stem Cell Population with Aging is Driven by Matrix Stiffness-Mediated mRNA Decay"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
D Cornelison (University of Missouri, United States)
"Driving Stemness Versus Differentiation in Myogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Maintaining Myofiber Function
Discussion Leader: David Glass (Regeneron Pharmaceuticals, United States)
9:00 am - 9:20 am
Mary Baylies (Memorial Sloan Kettering Cancer Center, United States)
"Regulation of Myonuclear Diversity in Skeletal Muscle Fibers"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Peleg Hasson (Technion - Israel Institute of Technology, Israel)
"FAP/Fibroblasts Diversification in the Embryonic Muscle"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Pengpeng Bi (University of Georgia, United States)
"Evolution and Developmental Mechanism of Chordate Muscle Fusion"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Bénédicte Chazaud (Université Claude Bernard Lyon 1, France)
"Restorative Macrophages Boost Muscle Stem Cell Fusion: Molecular Mechanisms"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Delphine Duprez (CNRS, France)
"Connective Tissue Fibroblasts as Organizer of Muscle Shape"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Vincent Gache (Institut NeuroMyoGène / INSERM, France)
"NumA1-Dependent Control of Skeletal Muscle Functions"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Rachelle Crosbie (University of California, Los Angeles, United States)
"Role of Sarcospan in Rewiring of Muscle Cell Adhesion to the Extracellular Matrix"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Satellite Cell Quiescence
Discussion Leader: Bénédicte Chazaud (Université Claude Bernard Lyon 1, France)
6:00 pm - 6:20 pm
Philippos Mourikis (East-Paris University / Mondor Institute, France)
"Investigation of Pax7 Multipotent Cells in the Postnatal Skeletal Muscle"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Isabella Scionti (INMG-PGNM, France)
"LSD1 Controls a Nuclear Checkpoint in Wnt/ß-Catenin Signaling to Regulate Muscle Stem Cell Self-Renewal"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Marine Theret (University of British Columbia, Canada)
"Fibro-Adipogenic Progenitors and TGFb Signaling Pathway, an Imperfect Duo"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
Colin Crist (McGill University, Canada)
"The Adhesion GPCR GPR116 Maintains the Quiescent Satellite Cell Pool via Nuclear Activity of ß-arrestin1"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Katarzyna Whysall (University of Galway, Ireland)
"Oxidised MicroRNAs as Novel Players in Muscle Wasting"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Jerome Feige (Nestlé Institute of Health Sciences, EPFL, Switzerland)
"Controlling Satellite Cell Function"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms Driving Disease Pathology
Discussion Leader: Peter Currie (Australian Regenerative Medicine Institute, Australia)
9:00 am - 9:20 am
Jim Dowling (Hospital for Sick Children, Canada)
"Myotubularin and its Role in Muscle Development and Disease"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Valentina Maria Lionello (University College London, United Kingdom)
"Modelling X-linked Centronuclear Myopathy Using Advanced Human Skeletal Muscle Models"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Ping Hu (Guangzhou Laboratory, China)
"Muscle Stem Cells in Non-Muscle Disease"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Michael Kyba (University of Minnesota, United States)
"The Double Homeobox Gene Family in Development and Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Viviana Moresi (CNR Institute of nanotechnology, Italy)
"Treating Duchenne Muscular Dystrophy with Cytoplasmic Histone Deacetylase 4"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Denis Guttridge (Medical University of South Carolina, United States)
"Insights on Oncogenic Functions of MyoD in Rhabdomyosarcoma"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Gabrielle Kardon (University of Utah, United States)
"The Origin of the Diaphragm and Congenital Diaphragmatic Hernias"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Frieder Schock (McGill University, Canada)
"The Oxoglutarate Dehydrogenase Complex is Involved in Myofibril Growth and Z-disc Assembly in Drosophila"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Metabolic Regulation of Muscle
Discussion Leader: Rachelle Crosbie (University of California, Los Angeles, United States)
6:00 pm - 6:20 pm
Clara Peek (Northwestern University, United States)
"Circadian Clock Control of Muscle Stem Cell Fate and Regeneration"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Marc Egerman (Regeneron, United States)
"Activin and BMP Signaling Regulation of Human Muscle Cells"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Mireille Khacho (University of Ottawa, Canada)
"Mitochondrial Dynamics Regulate the Quiescent State of Adult Muscle Stem Cells"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Nicolas Dumont (Université de Montréal, Canada)
"Bioactive Lipids Signaling Network Regulates Muscle Stem Cell Myogenic Progression in Skeletal Muscle Regeneration and Dystrophies"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Remi Mounier (Institut NeuroMyoGène / CNRS, France)
"NUAK1, as a Novel Molecular Pathway Linking Metabolic Regulation and Muscle Stem Cell Fate"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Katrien De Bock (ETH Zurich, Switzerland)
"Metabolic Crosstalk in the Muscle"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Epigenetic Control of Muscle Development and Regeneration
Discussion Leader: D Cornelison (University of Missouri, United States)
9:00 am - 9:20 am
Chiara Lanzuolo (National Institute of molecular Genetics (INGM) & National research Council (CNR), Italy)
"Chromatin Remodeling in Physiological and Pathological Muscular Aging"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Stephen Tapscott (Fred Hutchinson Cancer Center, United States)
"DUX4 and the Molecular Mechanisms of FSHD"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Joana Esteves de Lima (Institut Mondor - INSERM, France)
"Skeletal Muscle Cell Identity is Preserved by H3.3 Histone Chaperones"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Huating Wang (The Chinese University of Hong Kong, Hong Kong SAR China)
"Multiscale 3D Genome Reorganization During Muscle Stem Cell Lineage Progression and Muscle Aging"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Yarui Diao (Duke University, United States)
"The Inflammatory and Fibrotic Niche Impairs Skeletal Muscle Regeneration in Ischemic-Damaged Limbs by Inducing Precocious Differentiation of Satellite Cells"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Carmen Birchmeier (Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany)
"Roles of Oscillatory Gene Expression in Muscle Stem Cells"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Fabien Le Grand (INMG, France)
"Setdb1 Safeguards Genome Integrity in Muscle Stem Cells to Allow for Regenerative Myogenesis and Inflammation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Tom Cheung (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Post-Transcriptional Regulation of Muscle Stem Cell Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Contributions of the Niche to Satellite Cell Function
Discussion Leader: Peleg Hasson (Technion - Israel Institute of Technology, Israel)
6:00 pm - 6:20 pm
Shahragim Tajbakhsh (Institut Pasteur, France)
"Myogenic Stem Cell Diversity and Function"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Karyn Esser (University of Florida, United States)
"The Muscle Circadian Clock and MyoD1 as Partners in Muscle Homeostasis"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Francesca Boscolo Sesillo (University of California San Diego, United States)
"Discovery the Mechanisms Leading to Muscle Stem Cell Activation During Pregnancy"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
Florian Bentzinger (Université de Sherbrooke, Canada)
"Cell-Autonomous ECM Regulation of MuSC Function"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Foteini Mourkioti (University of Pennsylvania, United States)
"Mechanosensing Regulation of Muscle Stem Cells"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure