Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Muscle Stem Cell Dysfunction with Aging: Causes and Consequences
Dr. Pura Munoz-Canoves will provide the keynote address with data from her lab as well as her perspective on the field of myogenesis.
Discussion Leader: Francesco Girardi (Centre of Research in Myology, France)
3:15 pm - 3:55 pm
Pura Munoz-Canoves (Pompeu Fabra University / Spanish National Cardiovascular Research Centre, Spain)
"Muscle Stem Cell Dysfunction with Aging: Causes and Consequences"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Development and Regeneration in Skeletal Myogenesis
Discussion Leaders: Georgios Kotsaris (Freie Universität Berlin, Germany) and Marine Theret (University of British Columbia, Canada)
5:30 pm - 5:45 pm
Omid Mashinchian (Nestlé Institute of Health Sciences / École Polytechnique Fédérale de Lausanne, Switzerland)
"An Engineered Multicellular Stem Cell Niche for the 3D Derivation of Human Myogenic Progenitors from iPSCs"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Beatrice Biferali (Sapienza University of Rome, Italy)
"H3K9 Methylation Controls Fibro-Adipogenic Progenitors Identity and Skeletal Muscle Repair"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Thibaut Desgeorges (Institut NeuroMyoGène, France)
"Crosstalk of Glucocorticoid Receptor and AMP-K in Macrophages During Skeletal Muscle Regeneration"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Francesco Girardi (Centre of Research in Myology, France)
"TGFβ Signaling Curbs Cell Fusion and Muscle Regeneration"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Jennifer Petrosino (Ohio State University, USA)
"METTL3 Is an mRNA Modifying Methyltransferase that Regulates Hypertrophy in Skeletal Muscle"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Jared Talbot (Ohio State University, USA)
"Dynamic Muscle Precursor Cell Movements in Zebrafish Require Six-Family Genes"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cellular Crosstalk and Basic Mechanisms in Ageing and Disease
Discussion Leader: Giselle Joseph (Novartis Institutes for BioMedical Research, USA)
9:00 am - 9:15 am
Shilpita Sarcar (University College London, United Kingdom)
"Human iPS Cell-Derived Bioengineered 3D Constructs for Complex Skeletal Muscle Tissue and Disease Modeling"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Marcela Cataldi (Atrium Health, USA)
"Ribitol and ISPD Therapy for FKRP Dystroglycanopathy: A Mouse Model Study"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Giorgia Careccia (Università Vita-Salute San Raffaele, Italy)
"HMGB1 Redox Isoforms as Novel Targets in Muscular Dystrophy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Gillian Fitzgerald (ETH Zurich, Switzerland)
"Using Single Cell RNA Sequencing to Determine the Cellular Origins and Mechanisms of Human Muscle Fatty Infiltration"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Annarita Scaramozza (University of California, San Francisco, USA)
"Muscle Heterogeneity: Do Differences Matter?"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Amin Cheikhi (University of Pittsburgh, USA)
"Single Cell Flow Imaging Analysis of Muscle Satellite Cells Reveals Age-Dependent Storage of Pax7 mRNAs in Processing Bodies"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
Discussion Leader: Marielle Saclier (University of Milan, Italy)
1:30 pm - 2:30 pm
Panel Discussion
Job Opportunities for Early Career Scientists
Mary Baylies (Memorial Sloan Kettering Cancer Center, USA)
Michael Franti (Boehringer Ingelheim, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes