Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Viruses, Cancer and Stem Cell
Discussion Leader: Alan Rickinson (University of Birmingham, United Kingdom)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Patrick Moore (University of Pittsburgh, USA)
"Why Do Viruses Cause Cancer?"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Irving Weissman (Stanford University School of Medicine, USA)
"Normal and Neoplastic Stem Cells"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
EBV Infection and NPC Pathogenesis
Discussion Leader: Alan Chiang (The University of Hong Kong, Hong Kong SAR China)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Paul Farrell (Imperial College London, United Kingdom)
"EBV Genome Sequence Variation: Geography, Function and Disease"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Bill Sugden (University of Wisconsin-Madison, USA)
"How EBV Prevails During Productive Infection"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Rebecca Skalsky (Oregon Health and Science University, USA)
"Regulation of Host Signaling Pathways by EBV miRNAs"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Bo Zhao (Brigham and Women's Hospital / Harvard Medical School, USA)
"NPC Epigenetic Landscapes and Super-Enhancers"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Lin Feng (Sun Yat-sen University Cancer Center, China)
"Nasopharyngeal Carcinoma Susceptibility Gene TNFRSF19 Inhibits TGFβ Signaling and Promotes Tumorigenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Miao Xu (Sun Yet-sen University Cancer Center, China)
"Genome Sequencing Analysis Identifies Epstein-Barr Virus Subtypes Associated with the Risk of Nasopharyngeal Carcinoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Quynh-Thu Le (Stanford University, USA) and Maria Lung (University of Hong Kong, Hong Kong SAR China)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Lytic and Latent EBV Infection
Discussion Leader: Mei-Ru Chen (National Taiwan University, Taiwan)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Shannon Kenney (University of Wisconsin-Madison, USA)
"Differentiation-Dependent Lytic EBV Reactivation in Epithelial Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Lori Frappier (University of Toronto, Canada)
"New Functions for EBV Proteins in Manipulating Cellular Processes Important for Cancer"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Mu Sheng Zeng (Sun Yat-Sen University Cancer Center, China)
"The Key Cellular Factors in EBV Infection of Epithelial Cells"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Risk Factors and Novel Markers for NPC
Discussion Leader: Jin-Xin Bei (Sun Yat-Sen University Cancer Center, China)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Wei-Hua Jia (Sun Yat-sen University Cancer Center, China)
"Genetic Predisposition of Nasopharyngeal Carcinoma: Evidence from GWAS and Sequencing Studies"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Jin-Ching Lin (National Yang-Ming University, Taiwan)
"Application of Plasma EBV DNA Assay in Daily Practice of NPC Management"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Dennis Lo (Chinese University of Hong Kong, Hong Kong SAR China)
"Plasma EBV DNA for Screening Nasopharyngeal Carcinoma"
10:35 am - 10:45 am
Discussion
10:45 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
Maria Lung (University of Hong Kong, Hong Kong SAR China)
"New Insights in NPC Detection Utilizing Circulating Tumor Cell Enumeration and NGS Analysis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Scott Bratman (Princess Margaret Cancer Centre, Canada)
"Circulating Tumor DNA: Detection and Applications in Curable Cancers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Molecular Profiling of NPC
Discussion Leader: Andrew Futreal (University of Texas MD Anderson Cancer Center, USA)
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:25 pm
Kwok Wai Lo (The Chinese University of Hong Kong, Hong Kong SAR China)
"Acquired Genomic Changes in Nasopharyngeal Carcinoma"
4:25 pm - 4:35 pm
Discussion
4:35 pm - 4:55 pm
Wei Dai (The University of Hong Kong, Hong Kong SAR China)
"Genetic Susceptibility in Nasopharyngeal Carcinoma"
4:55 pm - 5:05 pm
Discussion
5:05 pm - 5:35 pm
Daniel De Carvalho (University Health Network / University of Toronto, Canada)
"Translational Aspects of DNA Methylation in Cancer"
5:35 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Selected from Poster Abstracts: Ming-Han Tsai (National Yang-Ming University, Taiwan)
"The M81 Epstein-Barr Virus Associated RNA2 Enhances CXCL8 Production and Spontaneous Virus Lytic Replication in Primary B Lymphocytes"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Microenvironment of NPC
Discussion Leader: Eric Stanbridge (University of California, Irvine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Pierre Busson (Gustave Roussy, France)
"Galectin-9 and Other Factors of Immune Escape in NPC Tumor Microenvironment: How to Bring Them Under Control?"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Maria Massucci (Karolinska Institutet, Sweden)
"A Role of Bacterial Co-Infection in the Pathogenesis of NPC?"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Selected from Poster Abstracts: Alan Chiang (The University of Hong Kong, Hong Kong SAR China)
"A Novel Mechanism of Induction of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-Positive Epithelial Malignancies Through Intracellular Iron Chelation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Zhi-Ming Mai (The University of Hong Kong, Hong Kong SAR China)
"Are Exposure to Sunlight, Dietary Vitamin D Intake, Serum and Genetically Derived 25-Hydroxyvitamin D Risk Factors of Nasopharyngeal Carcinoma (NPC)?"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Shibing Li (Sun Yat-sen University Cancer Center, China)
"ISNLx Regulates Cellular Metabolic Reprogramming and Is a Potential Therapeutic Target for Nasopharyngeal Carcinoma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Jun Zhang (The University of Hong Kong, Hong Kong SAR China)
"Epstein-Barr Virus-Encoded LMP1 Reprograms Glucose Metabolism to Drive Cell Motility Through mTORC2/PDHE1α-Mediated Histone Acetylation in Nasopharyngeal Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Xuefeng Liu (Georgetown University, USA)
"Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Dewi Kartikawati Paramita (Universitas Gadjah Mada, Indonesia)
"NPC Strip G: Rapid Test Strip Detecting IgG Against EBV Antigens in NPC"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Challenges and Novel Approaches in NPC Treatment
Discussion Leader: Brian O'Sullivan (University of Toronto, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Danny Rischin (Peter MacCallum Cancer Centre, Australia)
"Role of Chemotherapy in NPC: Not Novel, but Still Challenging"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Jun Ma (Sun Yat-Sen Medical University, China)
"Comprehensive Treatment Strategy in Locoregionally Advanced Nasopharyngeal Carcinoma"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Anne Lee (The University of Hong Kong, Hong Kong SAR China)
"Challenges and Novel Approaches in Radiotherapy for Nasopharyngeal Carcinoma"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Troy Messick (The Wistar Institute, USA)
"Development of an EBNA1 Inhibitor for the Treatment of NPC: Toward First-in-Human Studies"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunotherapy of NPC
Discussion Leader: Dora Kwong (University of Hong Kong, Hong Kong SAR China)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Lillian Siu (Princess Margaret Cancer Centre, Canada)
"Immune and Other Biomarkers of Resistance to Anti-PD1 Therapy in NPC"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Rajiv Khanna (QIMR Berghofer Medical Research Institute, Australia)
"Adoptive T Cell Therapy for NPC: Immune Correlates to Immune Contexture"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Graham Taylor (University of Birmingham, United Kingdom)
"The NPC Immunotherapy Landscape"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Han Chong Toh (National Cancer Centre Singapore, Singapore)
"Cellular Immunotherapy for Nasopharyngeal Cancer: Learning from the Past for a Better Tomorrow"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Brigette Ma (The Chinese University of Hong Kong, Hong Kong SAR China)
"Immune Checkpoint Inhibitor in the Treatment of Nasopharyngeal Carcinoma: A Clinical Overview"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Keynote Session: Future Perspectives in NPC Research and Treatment
Discussion Leader: Quynh-Thu Le (Stanford University, USA)
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:45 pm
Tak Mak (Princess Margaret Cancer Centre, University Health Network, Canada)
"Beyond Targeting Oncogenes: Future Anti-Cancer Strategies"
4:45 pm - 5:00 pm
Discussion
5:00 pm - 5:40 pm
Lawrence Young (University of Warwick, United Kingdom)
"The Future of NPC Research: Opportunities and Challenges"
5:40 pm - 5:55 pm
Discussion
5:55 pm - 6:00 pm
Closing Remarks
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure