Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Natural Products in the Service of Human Health
Discussion Leader: Michael Tarselli (SLAS, USA)
7:40 pm - 8:20 pm
Steven Projan (Beat the Reaper, USA)
"The Economics of Antibacterial Drug Development, Getting Biotech and Big Pharma Back in the Game"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Amos Smith (University of Pennsylvania, USA)
"Recent Advances in Natural Product and Bioactive Compound Synthesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Discovery and Chemistry of New Secondary Metabolites
Discussion Leaders: Elizabeth Meier (Zymergen, USA) and David Olson (University of California, Davis, USA)
9:00 am - 9:30 am
Olga Genilloud (Fundación MEDINA, Spain)
"Mining Microbial Metabolome: A New Paradigm in Natural Products Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Tomoyasu Hirose (Kitasato Institute for Life Sciences, Kitasato University, Japan)
"Utilization of Hydrophobic TAGs for Synthesis of Unique Peptide Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Carole Bewley (National Institutes of Health, USA)
"Insights from Screening 10,000 Marine Natural Products Extracts for Antimicrobial Activity"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Christina Smolke (Antheia / Stanford University , USA)
"Microbial Biosynthesis of Complex Plant-Derived Natural Products"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Dee Casteel (Bucknell University, USA) and Elizabeth Meier (Zymergen, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Constructing Architecturally Complex Molecules
Discussion Leader: Jeff Ciavarri (Takeda Pharmaceuticals, USA)
7:30 pm - 8:00 pm
Maria Christina White (University of Illinois at Urbana-Champaign, USA)
"Molecular Surgery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Mohammad Movassaghi (Massachusetts Institute of Technology, USA)
"Complex Alkaloid Total Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Richard Taylor (University of Notre Dame, USA)
"Conformation-Activity Relationships in Complex Natural Products Inspired by Biosynthesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methods Development in Pursuit of Bioactive Molecules
Discussion Leader: Mariya Kozytska (Wave Life Sciences, USA)
9:00 am - 9:30 am
Marisa Kozlowski (University of Pennsylvania, USA)
"Oxygen Driven Fragment Coupling by Activation of C-H, N-H and O-H Bonds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Helge Bode (Goethe University Frankfurt, Germany)
"NRPS-Engineering for the Modification and De Novo Generation of Peptide Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Alan Cherney (Amgen, USA)
"The Sweet Taste of Replacing Hydrogen with Glucose: Catalytic Synergy for Chemoselective Enzymatic Reductions"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Pamela Silver (Harvard University, USA)
"Deploying Natural Design Principles for Cell-Based Factories"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Synthetic Biology and Chemistry
Discussion Leader: Jennifer Leeds (Novartis Institutes for BioMedical Research, USA)
7:30 pm - 8:00 pm
Helen Blackwell (University of Wisconsin-Madison, USA)
"Chemical Tools to Intercept and Interrogate Bacterial Communication Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Dean Toste (University of California, Berkeley, USA)
"Organic Reactions Inspired by the Chemistry of Gold"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jeff Ciavarri (Takeda Pharmaceuticals, USA)
"Discovery of TAK-243: An Investigational, First-in-Class Inhibitor of the Ubiquitin Activating Enzyme"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Paradigm Shifting Technology
Discussion Leader: Doug Johnson (Biogen, USA)
9:00 am - 9:30 am
Deepak Nijhawan (University of Texas Southwestern Medical School, USA)
"Using Old Chemistry to Find New Cancer Targets"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Dustin Maly (University of Washington, USA)
"Engineered Protein Switches for Studying Dynamic Cellular Processes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Ruben Tommasi (Entasis Therapeutics, USA)
"Improving Our Approach Towards Gram-Negative Drug Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Martin Eastgate (Bristol-Myers Squibb, USA)
"Innovation in the Synthesis of Complex Pharmaceuticals"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Carlos Zepeda (Ontario Institute for Cancer Research, Canada)
"Novel Benzamide Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Complex Molecular Drug Discovery
Discussion Leader: Philip Kym (AbbVie, USA)
7:30 pm - 8:00 pm
Michael Patane (Astellas Pharmaceuticals, USA)
"Lifting the Body's Energy Embargo"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Marvin Miller (University of Notre Dame, USA)
"Design, Syntheses and Studies of Antibiotics to Circumvent Bacterial Resistance"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Nicholas Meanwell (Bristol-Myers Squibb, USA)
"Inhibitors of HIV-1 Maturation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Product-Inspired Medicinal Chemistry
Discussion Leaders: Michael Acker (Novartis Institutes for BioMedical Research, USA) and Mohindra Seepersaud (LifeMine Therapeutics, USA)
9:00 am - 9:30 am
Jef De Brabander (University of Texas Southwestern Medical Center, USA)
"Discovery, Target Identification and Validation of a Novel Class of Potent Highly Selective Anti-Colon Cancer Small Molecules"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Ian Seiple (University of California, San Francisco, USA)
"Can We Beat Nature? Rational Design, Chemical Syntheses and Molecular Mechanisms of Action of New Antibiotics Based on Old Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Lauren Monovich (Novartis Institutes for Biomedical Research, USA)
"Design of Technology-Compatible Cyclic Peptide Scaffolds with Oral Bioavailability"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Chris Heise (Genentech, USA)
"Optimization of the Arylomycin Natural Product into Gram-Negative Antibiotics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The State-of-the-Art of Discovery in Natural Products
Discussion Leader: James Leahy (University of South Florida, USA)
7:30 pm - 8:15 pm
Frank Petersen (Novartis Institutes for Biomedical Research, Switzerland)
"Natural Product Sciences in Modern Drug Discovery and Paths to the Future"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
Phil Baran (Scripps Research , USA)
"Studies in Natural Product Synthesis"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure