Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Leveraging Structural Biology to Study Natural Product Biosynthesis
3:45 pm - 4:20 pm
"Snapshots of Metalloenzymes Involved in Natural Product Biosynthesis"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exploiting Nature to Make Natural Product Derivatives / Preparation of Complex Bioactive Natural Products
7:30 pm - 7:45 pm
"Microbial Synthesis and Evolution of Pharmaceutical Leads"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"New Methods for Biosynthetic Derivatization of Antimicrobial Orthosomycins to Engage a Unique Ribosomal Binding Site"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Investigation of Lipid II-Binding Antimicrobial Peptides"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Total Synthesis of Mytilipin B"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Asymmetric Synthesis of Caged Indolenine Alkaloids, Strictamine and Arborisidine"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Development of a Unified Strategy for the Synthesis of Delavatine A and Incarviatone A"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Synthetic Efficiency via Computation and Catalyst Design / Tools for Characterizing Natural Products and Their Biosyntheses
9:00 am - 9:15 am
"From the Construction of Valuable Azacycles to New Catalyst Design: Using Catalyst-Controlled C-H Amination to Access Nitrogen-Containing Small Molecules"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Total Synthesis of Indoloditerpenoid Natural Products Enabled by Computational Augmentation of a Transform-Guided Retrosynthetic Strategy"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Synthesis of (-)-Melodinine K: A Case Study in Efficiency"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"A Modified Isolation Chip for In Situ Cultivation and Isolation of Antimicrobial Drug-Producing Bacteria from Social Spider Nests"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Partial Promiscuity of Dirigent Proteins and Their Application for Lignan Analog Synthesis"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Small Molecules to Probe Dynamic Protein-Protein Interactions in Fatty Acid and Polyketide Biosynthesis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
1:30 pm - 2:30 pm
Panel Discussion
Careers in Natural Products
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
