| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: Global Positioning System, APOE4 and Memory |
| Discussion Leader: Luciano D'Adamio (Albert Einstein College of Medicine, USA) |
| 7:40 pm - 8:20 pm | John O'Keefe (University College London, United Kingdom)
"GPS and Memory" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Thomas Sudhof (Stanford University, USA)
"ApoE Function in Neurons" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Seeding and Spreading
of Proteopathic Seeds |
| Discussion Leader: John Trojanowski (University of Pennsylvania, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:40 am | Virginia Lee (University of Pennsylvania, USA)
"Transmission of Alpha-Synuclein in Synucleinopathies" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Lary Walker (Emory University, USA)
"The Prion Paradigm and Alzheimer's Disease" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Karen Ashe (University of Minnesota, USA)
"Beyond Tangles: Synaptic and Cognitive Dysfunction Caused by Non-Fibrillar Tau" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Yun-Ru Chen (Academia Sinica, Taiwan)
"The Discovery of Toxic TDP-43 Oligomers in TDP Proteinopathies" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Chiara Zurzolo (Pasteur Institute, France)
"Role of Tunneling Nanotubes in the Spreading of a-Syn Fibrils and Other Proteopathic Seeds" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Francesca-Fang Liao (University of Tennessee Health Science Center, USA)
"Can the Stress Regulating Heat Shock Factor HSF1 Be a Key Player in Synaptic Functions and Memory?" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Genetic and
Epigenetic Factors in Neurodegeneration |
| Discussion Leader: Bart De Strooper (VIB, KU Leuven, Belgium) |
| 6:00 pm - 6:05 pm | Introduction by Discussion Leader |
| 6:05 pm - 6:30 pm | Alison Goate (Icahn School of Medicine at Mount Sinai, USA)
"Role of Rare Variation in Risk for Alzheimer's Disease" |
| 6:30 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Andrew Teich (Columbia University, USA)
"A Systems Approach to Studying Synaptic Dysfunction in AD" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Rafael Fernandez-Chacon (Instituto de Biomedicina de Sevilla (IBiS) / Universidad de Sevilla / CSIC / CIBERNED, Spain)
"Cysteine String Protein-a (CSP-a) Maintains the Postnatal Quiescence of Neural Stem Cells Through Inhibition of mTOR" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:50 pm | Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, USA)
"Cell Type-Specific Epigenomic Analysis in the Neurodegenerating Brain" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Synaptic Plasticity in Health and Disease |
| Discussion Leader: Pablo Castillo (Albert Einstein College of Medicine, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:40 am | Jie Shen (Harvard Medical School, USA)
"Presenilins and Alzheimer's Disease: New Insight into the Pathogenic Mechanism" |
| 9:40 am - 9:55 am | Discussion |
| 9:55 am - 10:25 am | Ottavio Arancio (Columbia University, USA)
"Rearranging the Puzzle: A New View on Alzheimer's Disease Pathogenesis" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 11:05 am | Coffee Break |
| 11:05 am - 11:35 am | Inna Slutsky (Tel Aviv University, Israel)
"Transition Mechanisms from Physiology to Alzheimer's Disease Pathology" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Dieter Edbauer (German Center for Neurodegenerative Diseases (DZNE), Germany)
"The Role of TDP-43 in Trafficking and Signaling in Neurons" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Zohreh Farsi (Max-Planck Institute for Biophysical Chemistry, Germany)
"Single-Vesicle Imaging: A Novel Approach to Study the Vesicular Transporters and the Ion-Proton Exchangers on Synaptic Vesicles" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Jerrah Holth (Washington University in St. Louis, USA)
"The Interaction Between Sleep and Tau Pathology in the P301S Tauopathy Mouse Model" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Mitochondrial and Metabolic Dysfunction |
| Discussion Leader: Jie Shen (Harvard Medical School, USA) |
| 6:00 pm - 6:05 pm | Introduction by Discussion Leader |
| 6:05 pm - 6:35 pm | Giovanni Manfredi (Weill Cornell Medical College, USA)
"Mitochondria and Neurodegeneration" |
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:10 pm | Vanessa Morais (Institute of Molecular Medicine (IMM), University of Lisbon, Portugal)
"Quality Control Pathways of Neuronal Mitochondria" |
| 7:10 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:50 pm | Amantha Thathiah (University of Pittsburgh School of Medicine, USA)
"GPCR Dysfunction in Alzheimer's Disease" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Inflammation, Immunity and Neurodegeneration |
| Discussion Leader: David Holtzman (Washington University in St. Louis, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Christian Haass (Ludwig Maximilians University of Munich / German Center for Neurodegenerative Diseases (DZNE), Germany)
"Cellular Mechanisms of Alzheimer's Disease" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Morgan Sheng (Genentech, USA)
"The Role of Microglia in Neurodegeneration" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:15 am | Hui Zheng (Baylor College of Medicine, USA)
"An NFkB and Complement-Mediated Neuron-Glia Signaling in Neuronal Health and Alzheimer's Disease" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:50 am | Greg Petsko (Weill Cornell Medical College, USA)
"How Parkinson's Disease Starts - And How It Might Be Stopped" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:25 pm | Berislav Zlokovic (Keck School of Medicine of the University of Southern California, USA)
"Blood Brain Barrier: Cellular and Molecular Mechanisms of Neurodegeneration" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | APOE4, BACE1 and Ataxin 2 as Therapeutic Targets |
| Discussion Leader: Karen Ashe (University of Minnesota, USA) |
| 6:00 pm - 6:05 pm | Introduction by Discussion Leader |
| 6:05 pm - 6:45 pm | Joachim Herz (University of Texas Southwestern Medical Center, USA)
"Targeting ApoE4 for the Prevention of Alzheimer's Disease" |
| 6:45 pm - 6:55 pm | Discussion |
| 6:55 pm - 7:05 pm | Tien-Phat Huynh (Washington University School of Medicine, USA)
"Targeting Human APOE Using Antisense Oligonucleotides in APP Transgenic Mice" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:30 pm | Robert Vassar (Northwestern University, USA)
"BACE1: The Beta-Secretase Enzyme in Health and Alzheimer's Disease" |
| 7:30 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Aaron Gitler (Stanford University, USA)
"Therapeutic Reduction of Ataxin 2 Extends Lifespan and Rescues Pathological Features of ALS in TDP-43 Transgenic Mice" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Biomarkers and Therapeutics |
| Discussion Leader: Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:35 am | Leonard Petrucelli (Mayo Clinic College of Medicine, USA)
"C9orf72, Mechanisms of Toxicity and Therapeutic Potential" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Don Cleveland (Ludwig Institute for Cancer Research, USA)
"Gene Silencing Therapy for Human Neurodegenerative Disease" |
| 10:20 am - 10:35 am | Discussion |
| 10:35 am - 11:05 am | Coffee Break |
| 11:05 am - 11:35 am | Karen Duff (Columbia University, USA)
"Tau Spread, Clearance and Therapeutics to Prevent It" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Lennart Mucke (Gladstone Institute of Neurological Disease, University of California, San Francisco, USA)
"Mechanisms and Treatment of Neural Dysfunction in Alzheimer's Disease" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Protein Homeostasis |
| Discussion Leader: Cheryl Wellington (The University of British Columbia, Canada) |
| 6:00 pm - 6:05 pm | Introduction by Discussion Leader |
| 6:05 pm - 6:25 pm | Patrik Verstreken (VIB, KU Leuven, Belgium)
"Synaptic Protein Turnover for a Healthy Brain" |
| 6:25 pm - 6:35 pm | Discussion |
| 6:35 pm - 6:55 pm | Michael Lee (University of Minnesota, USA)
"Mutant Alpha-Synulcien Causes Postsynaptic Deficits by Inducing Tau Mislocalization to Dendritic Spines and AMPA Receptor Dysfunction" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Li Gan (Gladstone Institute of Neurological Disease, University of California, San Francisco, USA)
"Converging Pathways in AD and FTD" |
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 7:40 pm | Sara Calafate (Janssen Pharmaceutica / Vlaams Instituut voor Biotechnologie (VIB), KU Leuven, Belgium)
"Synaptic Modulation of Tau Pathology Propagation" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Lucia Chavez Gutierrez (VIB, KU Leuven, Belgium)
"PSEN Structural Metastability, Implications for Alzheimer's Disease" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
