| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Synaptic Dysfunction in Neurodegeneration |
| Discussion Leader: Maj-Linda Selenica (USF Health Byrd Alzheimer's Institute, USA) |
| 3:15 pm - 3:20 pm | Opening Remarks |
| 3:20 pm - 3:35 pm | Sara Calafate (Janssen Pharmaceutica / Vlaams Instituut voor Biotechnologie (VIB), KU Leuven, Belgium)
"Synaptic Modulation of Tau Pathology Propagation" |
| 3:35 pm - 3:40 pm | Discussion |
| 3:40 pm - 3:55 pm | Cheng Fang (Boston University, USA)
"Neuronal System to Detect Prion Toxicity" |
| 3:55 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Cell Biology of Neurodegeneration: Toxic Species, Endocytosis, Trafficking, and Degradation |
| Discussion Leaders: Marc Aurel Busche (Technical University of Munich, Germany) and Tatyana Shelkovnikova (Cardiff University, United Kingdom) |
| 5:30 pm - 5:50 pm | Daniela Papadia (Karolinska Institutet, Sweden)
"A Neuroprotective Role for Insulin and Pyruvate in Energy Compensatory Mechanisms" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Hermien Acx (Vlaams Instituut voor Biotechnologie (VIB), KU Leuven, Belgium)
"Accumulation of APP CTFs: Not the Cause of Neurodegeneration in Gamma-Secretase KO Mice" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Theresa Pohlkamp (University of Texas Southwestern Medical Center, USA)
"Reelin and EphB/Ephrin-B Interplay: Neuronal Migration or Synaptic Plasticity?" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Smriti Sangwan (University of California, Los Angeles, USA)
"Structure Guided Approach Reveals the Basis of Neurotoxicity in ALS" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Translational Applications |
| Discussion Leader: Maria-Belen Lopez (Institut du Cerveau et de la Moelle Épinière / INSERM U1127, France) |
| 9:00 am - 9:20 am | Marie Bordone (Instituto de Medicina Molecular, Universidade de Lisboa, Portugal)
"Going Deep in the Brain with Alternative Splicing in Parkinson's Disease" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Vishal Jain (Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organisation, India)
"Neuronal Release of Alpha-Synuclein During Hypoxia Causes Neuroinflammation and Exacerbates Neurodegeneration Through Mac1/NOX2 Pathway" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Lisa McGinley (University of Michigan, USA)
"Human Neural Stem Cells Improve Cognition and Disease Pathology in the APP/PS1 Alzheimer's Mouse Model" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Tien-Phat Huynh (Washington University School of Medicine, USA)
"Use of Anti-Sense Oligonucleotides: An Approach to Knock Down APOE in the Adult Brain" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Pathways to Success in Neurobiology |
| Discussion Leaders: Courtney Lane-Donovan (University of Texas Southwestern Medical Center, USA) and Lorena Saelices Gomez (University of California, Los Angeles, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Pathways to Success in Neurobiology" |
|
- Robert Finkelstein (National Institute of Neurological Disorders and Stroke, NIH, USA)
- David Holtzman (Washington University in St. Louis, USA)
- Joachim Herz (University of Texas Southwestern Medical Center, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
