Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Protein Processing, Aggregation and Toxicity
Discussion Leader: Tien-Phat Huynh (Washington University School of Medicine, USA)
3:15 pm - 3:20 pm
Opening Remarks
3:20 pm - 3:35 pm
Maria Szaruga (VIB, KU Leuven, Belgium)
"Molecular Mechanisms Underlying Familial Alzheimer's Disease, Providing the Basis for Novel Drug Discovery Strategies"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Olga Zolochevska (University of Texas Medical Branch, USA)
"Epigenetic Modulation of Synaptic Resilience in Alzheimer's Disease"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cellular and Subcellular Mechanisms of Neurodegeneration
Discussion Leader: Kriti Chaplot (Indian Institute of Science Education and Research (IISER), India)
5:30 pm - 5:50 pm
Enrico Bagnoli (CURAM, National University of Ireland Galway, Ireland)
"DOPAL-Treated Olfactory Bulb Organotypic Slices as a Model of Prodromal Parkinson's Disease"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Stephanie Kyle (Emory University, USA)
"Using a Novel LSD1-Mediated Model of Neurodegeneration to Study the Molecular Mechanism of Alzheimer's Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Eileen Ruth Torres (Oregon Health & Science University, USA)
"Apolipoprotein E Isoform-Specific Effects on Cortical Oxysterols in Mice"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Elisa Navarro (Icahn School of Medicine at Mount Sinai, USA)
"Trans-Regulation of Gene Expression in Human Monocytes and Macrophages Implicate the Lysosomal Pathway in the Pathogenesis of Parkinson's Disease"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Glia and Neuroinflammation
Discussion Leader: Jessica Rexach (UCLA Neurology, USA)
9:00 am - 9:20 am
Emily Button (University of British Columbia, Canada)
"Pharmacological and Genetic Manipulation of Lipoprotein Metabolism Alters Neuroinflammation in APP/PS1 Mice"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Brian Lananna (Washington University in St. Louis, USA)
"The Astrocytic Circadian Clock Gates Neuroinflammation and Neuronal Health Through Regulation of Alzheimer's Disease Biomarker Chi3l1 (YKL-40)"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Hazel Hall-Roberts (University of Oxford, United Kingdom)
"Phenotypic Studies of the R47H Alzheimer's Disease Mutation of TREM2 Using Human iPSC-Macrophages"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Alexandre Trotier (National University of Ireland Galway, Ireland)
"Mechanically Induced Neuroinflammation to Reproduce Peri-Electrode Gliosis Macro Environment"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
An interactive Q&A session with a panel of leaders in the field.
Discussion Leaders: Peter Chung (University of Chicago, USA) and Heather Rice (VIB & KU Leuven Center for Brain & Disease Research, Belgium)
1:30 pm - 2:30 pm
Panel Discussion
Career Paths and Experiences
Cheryl Wellington (University of British Columbia, Canada)
Andrew Yoo (Washington University School of Medicine, USA)
Judith Steen (Harvard Medical School, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes