Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Intercellular Communication in Alzheimer's Disease
Discussion Leader: Biswarathan Ramani (University of California San Francisco, United States)
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:35 pm
Mitali Tyagi (University of Utah, United States)
"Arc Mediates the Intercellular Transfer of Tau"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Gerard Crowley (UK Dementia Research Institute at University College London, United Kingdom)
"Chemogenetic Activation of the Perforant Pathway Induces Microglial Complement Signalling and Synapse Loss"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Identifying and Characterizing Neurodegeneration
Discussion Leader: Amanda McQuade (University of California, San Francisco, United States)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:50 pm
Sahba Seddighi (NIH/NINDS, United States)
"Proteogenomic Identification of Mis-splicing Biomarkers in ALS/FTD"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:10 pm
Benedikt Hölbling (University College London, United Kingdom)
"A High-throughput Screening Platform to Identify Modulators of Endogenous C9orf72 RAN Translation"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:30 pm
Jillybeth Burgado (UCSD/Salk, United States)
"Astrocyte Transcriptome and Secretome Remodeling of Alzheimer’s Disease: Contributions to Neuronal Dysfunction"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 7:20 pm
Celeste Karch (Washington University School of Medicine, United States)
"Keynote: Genetic Drivers of Alzheimer's Disease"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Innovations in Therapeutics
Discussion Leader: Edward Harding (University of Cambridge, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Lesley Golden (University of Kentucky, United States)
"APOE Allele Switching as a Therapeutic Approach for Alzheimer's Disease: Development of Novel Transgenic Mouse Models"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Phillip Gross (Georgetown University, United States)
"Clearance of Senescent-Like Microglia Improves Remyelination in a Mouse Model of Focal Demyelination"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Rachel Knopp (University of Washington, United States)
"Senolytics have Age-Specific Effects in the SAMP8 Mouse Model"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Khaled Abd-Elrahman (University of Ottawa, Canada)
"M1 Muscarinic Acetylcholine Receptors as a Therapeutic Target for Alzheimer’s Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 10:50 am
Isabel Salas (Salk Institute, United States)
"Targeting Astrocyte Glypican 5 to Prevent Synapse Dysfunction in Alzheimer's Disease"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Neuronal Excitability and Neurodegeneration
Discussion Leader: Javier Rueda-Carrasco (University College London, United Kingdom)
1:30 pm - 1:45 pm
Steven Boggess (University of California, San Francisco, United States)
"Uncovering Mechanisms of Hyperexcitability in Neurodegenerative Disease with Functional Genomics"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Hannah Phillips (SUNY Upstate Medical University, United States)
"Restoring Prefrontal Hypoactivity Rescues Social Behavior Deficits in a Mouse Model of Late-stage FTD"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Eric Bancroft (Texas A&M College of Medicine, United States)
"Effects of Extracellular S100B on Voltage-gated Channel Activity in Dopaminergic Neurons"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes