Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Advances in Epigenetic and Circuit Mechanisms of Drug Addiction: Implications to Treatment
Discussion Leader: Marina Picciotto (Yale University, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Eric Nestler (Icahn School of Medicine at Mount Sinai, United States)
"Epigenetic Mechanisms of Drug Addiction"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Rita Valentino (National Institute on Drug Abuse, United States)
"New Vistas In Addiction Research"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular and Circuit Mechanisms of Opioid Addiction and Pain
Discussion Leader: Michelle Mazei-Robison (Michigan State University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Laura Bohn (UF Scripps Research, United States)
"The Pharmacology of Mu Opioid Biased Agonists"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Stefan Schulz (University Hospital Jena, Germany)
"Cellular Mechanisms of Opioid Analgesia, Tolerance, Side Effects and Withdrawal"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Nurulain Zaveri (Astraea Therapeutics, United States)
"Novel Mixed Mu/Nociception Biased Agonists for the Treatment of Pain and Addiction"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Gregory Scherrer (University of North Carolina at Chapel Hill, United States)
"Recent Advances in the Understanding the Function of Mu and Delta Opioid Receptors in Pain"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Rajita Sinha (Yale Stress Center, United States) and Diana Martinez (Columbia University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Learning Mechanisms of Drug Addiction
Discussion Leader: Karen Ersche (University of Cambridge, United Kingdom)
7:30 pm - 7:55 pm
Rita Fuchs (Washington State University, United States)
"Circuits of Reconsolidation of Cocaine Memories"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Gavan McNally (University of New South Wales, Australia)
"Cognitive Distortions in Compulsivity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Regina Carelli (University of North Carolina at Chapel Hill, United States)
"Role of Accumbens and mPFC in Encoding Drug-Induced Negative Affective States"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Muhammad Parvaz (Icahn School of Medicine at Mount Sinai, United States)
"Psychophysiological and Computational Tracking of Sensitivity to Reward Value in Substance Use"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Synaptic Mechanisms of Drug Addiction
Discussion Leader: Anjali Rajadhyaksha (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Yan Dong (University of Pittsburgh, United States)
"Novel Synaptic Mechanisms of Incubation of Cocaine Craving"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Kasia Radwanska (Nencki Institute of Experimental Biology, Polish Academy of Sciences, Poland)
"Role of Hippocampal Silent Synapses in an Individual Difference-Based Mouse Addiction Model"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Thomas Jhou (Medical University of South Carolina, United States)
"Rostromedial Tegmental Roles in Punishment and Cocaine Aversion"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Meaghan Creed (Washington University School of Medicine, United States)
"Role of Ventral Pallidum Projections in Appetitive and Aversive Learning"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Cassandra Gipson-Reichardt (University of Kentucky, United States)
"Novel Non-neuronal Cell Signaling Mechanisms of Synaptic Plasticity During Nicotine Seeking"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Addiction Theories
Discussion Leader: Rita Goldstein (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:55 pm
David Epstein (NIDA Intramural Research Program, NIH, United States)
"Theories of Addiction: Less 'or'! More 'and'!"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
James Jentsch (Binghamton University, United States)
"The Frontostriatal Dysfunction Theory of Addiction: Past, Present and Future"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Steve Negus (Virginia Commonwealth University, United States)
"Addiction As A Brain Disease: A Behavioral Pharmacology Perspective"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Diana Martinez (Columbia University, United States)
"Addiction as a Brain Disease: An Aspiring Philosopher's Perspective"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Animal Models of Drug Addiction and Relapse
Discussion Leaders: Anne-Noel Samaha (University of Montreal, Canada)
9:00 am - 9:25 am
Olivier George (University of California, San Diego, United States)
"The Escalation Model of Drug Addiction"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Michael Nader (Wake Forest School of Medicine, United States)
"Role of Social Hierarchy and Sex Differences in Cynomolgus Monkey Models of Drug Abuse"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Chris Pierce (Rutgers University, United States)
"Psychostimulant Versus Opioid Self-Administration in a Rat Model of Transgenerational Addiction"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Marco Venniro (University of Maryland School of Medicine, United States)
"The Protective Effect of Social Choice on Drug Use and Relapse in a Rat Model"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Nathan Marchant (Amsterdam UMC, Location VUmc / Vrije Universiteit Amsterdam, The Netherlands)
"Relapse After Punishment: Behavior and Circuits"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Morgan James (Rutgers University, United States)
"A Novel Model of Uncertain Intermittent Drug Self-Administration"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Erin Calipari (Vanderbilt University, United States)
"Role of Estrous Cycle in PIT: Implications for Sex Differences in Cocaine Intake"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Translational Research in Drug Addiction
Discussion Leader: Markus Heilig (Linkoping University, Sweden)
7:30 pm - 7:55 pm
Aldo Badiani (Sapienza University of Rome, Italy)
"Translational Behavioral and Imaging Studies on the Role of Context in Heroin Versus Cocaine Use"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sandra Comer (Columbia University, United States)
"Medications Development for Opioid Addiction: Do the Preclinical and Clinical Data Align?"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Courtney Miller (The Scripps Research Institute, United States)
"Nonmuscle Myosin IIB as a Therapeutic Target for Methamphetamine Addiction"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Matt Banks (VCU School of Medicine, United States)
"Testing the 10 Most Wanted: A Translational Algorithm"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Hedy Kober (Yale University, United States)
"The Circuitry of Cue-Induced Drug Craving in Humans"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Circuitry of Drug Addiction
Discussion Leader: Marisela Morales (National Institute on Drug Abuse, NIH, United States)
9:00 am - 9:25 am
John Mantsch (Medical College of Wisconsin, United States)
"Circuits of Stress-Induced Reinstatement of Cocaine Seeking"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sara Jones (Wake Forest University School of Medicine, United States)
"Circuit and Cellular Mechanisms of Chronic Amphetamine Maintenance Therapy in a Rat Model"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Kate Wassum (UCLA, United States)
"Striatal Cholinergic Interneurons and Motivated Behavior"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Nii Addy (Yale University, United States)
"Role of Dopamine Projections in Cocaine Relapse"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Kathryn Reissner (University of North Carolina at Chapel Hill, United States)
"Nucleus Accumbens Astroglia and Cocaine Relapse"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Rebecca Hofford (Wake Forest School of Medicine, United States)
"Neuroimmune Regulation of the Behavioral Effects of Cocaine"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
New Imaging Methods to Visualize the Effect of Addictive Drugs on the Brain
Discussion Leaders: Bruce Hope (National Institute on Drug Abuse, NIH, United States)
5:30 pm - 5:55 pm
Byungkook Lim (University of California, San Diego, United States)
"Viral Tools Using the Novel Recombinase System for Dissecting Specific Neuronal Circuitry"
5:55 pm - 6:05 pm
Discussion
6:05 pm - 6:30 pm
Rajtarun Madangopal (National Institute on Drug Abuse IRP, United States)
"FOS and Calcium"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Ream Al-Hasani (Washington University in St. Louis, United States)
"Novel Methods for In Vivo Detection of Opioid Peptides"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Seksiri Arttamangkul (Oregon Health & Science University, United States)
"New Methods for In Vivo Visualization of Opioid Receptors"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure