Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Thinking Outside the (Skinner) Box: Beyond Rodent Models for Studying Drug-Abuse
Discussion Leader: BaDoi Phan (University of Pittsburgh, United States)
3:45 pm - 4:00 pm
Madelyn Ray (Boston University School of Medicine, United States)
"Cell Type Specific Transcriptional Signatures Associated with Opioid Use Disorder Using Single Nuclei RNA-seq of Human Postmortem Brain"
4:00 pm - 4:05 pm
Discussion
4:05 pm - 4:20 pm
Gabriel Bosse (Universite Laval-CERVO, United States)
"Neurosteroids in Opioid Addiction"
4:20 pm - 4:25 pm
Discussion
4:25 pm - 4:30 pm
General Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Mechanisms in Drug-Seeking and Relapse
Discussion Leader: Katherine Savell (National Institute on Drug Abuse IRP, United States)
7:30 pm - 7:45 pm
Rajtarun Madangopal (National Institute on Drug Abuse IRP, United States)
"In Vivo Labeling and Molecular Characterization of Cocaine Relapse Ensemble Neurons in the Infralimbic Cortex Using a Photo-Activatable Calcium Integrator"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Kimberly Thibeault (Vanderbilt University, United States)
"Defining the Ensemble-Specific Activity Signatures Controlling Cocaine Reinforcement"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Caleb Browne (Icahn School of Medicine at Mount Sinai, United States)
"Transcriptome Profiling of the Brain’s Reward Circuitry in Heroin Self-Administration Identifies a Ventral Hippocampus Gene Network Related to Relapse Susceptibility"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Miguel Á. Luján (University of Maryland, School of Medicine, United States)
"Prenatal THC exposure promotes aberrant reward seeking and exacerbated dopaminergic encoding of reward-predictive cues in the adult offspring."
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Ileana Morales (University of Michigan, United States)
"Optogenetic Stimulation of the Central Nucleus of the Amygdala Intensifies and Narrows Incentive Salience Toward a Laser-Paired Remifentanil Reward"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The Role of Negative Affect and Drug Withdrawal in Drug Addiction
Discussion Leader: Sam Golden (The University of Washington, United States)
9:00 am - 9:15 am
Brianna George (Wake Forest School of Medicine, United States)
"The Interaction of Early-life Stress, Biological Sex, and Mesolimbic Dopamine Function on Vulnerability to Heroin Self-Administration"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Fabrice Chaudun (Unige, Switzerland)
"Cellular Determinants of Negative Reinforcement in Fentanyl Addiction"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Kimberly Newman (Rutgers University, United States)
"The Orexin/Hypocretin System Mediates Adverse Withdrawal States Driving Opioid Demand"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jessica Tooley (Washington University in St. Louis, United States)
"Opioid Withdrawal Potentiates Synaptic Output from the Ventral Pallidum to the Lateral Habenula"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Allison McDonald (Amsterdam UMC, VUmc, The Netherlands)
"The Role of the Nucleus Accumbens Shell in Alcohol Use Despite Negative Consequences in Rats"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Andrew Kesner (NIAAA, United States)
"Modeling Sleep Disruption During Spontaneous THC Withdrawal in Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Session
Discussion Leader: Marina Wolf (Oregon Health & Science University, United States)
1:30 pm - 2:20 pm
Panel Discussion
Career Development Session
James Jentsch (Binghamton University, United States)
Marina Picciotto (Yale University, United States)
2:20 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
