Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Emerging Topics in Neuroimmunology
This session will feature a keynote speaker, Nobel Laureate, Prof. Mario Capecchi.
Discussion Leader: Carla Shatz (Stanford University, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
Mario Capecchi (University of Utah School of Medicine, USA)
"The Presence of at Least Two Ontogenetic Distinct Microglia Populations in the Mammalian Brain"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michelle Monje (Stanford University, USA)
"Persistent Tri-Glial Dysfunction in Methotrexate Chemotherapy-Induced Neurological Impairment"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ido Amit (Weizmann Institute of Science, Israel)
"The Power of ONE: Immunology in the Age of Single Cell Genomics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuroimmunology Beyond Microglia
Discussion Leader: Hartmut Wekerle (Max Planck Institute of Neurobiology, Germany)
9:00 am - 9:20 am
Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Modulation of Neuroinflammation via Lymphatic Endothelial Growth Factor Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Gloria Choi (Massachusetts Institute of Technology, USA)
"Reversing Behavioral Abnormalities in Mice Exposed to Maternal Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Eric Song (Yale University, USA)
"Meningeal Lymphangiogenesis Effect on Malignancy of Glioblastoma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Antoine Louveau (University of Virginia, USA)
"Mobilization of Meningeal Immune Cells Using Integrin Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lawrence Steinman (Stanford University, USA)
"Setting Some Boundaries: Neurodegeneration vs. Neuroinflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Carla Shatz (Stanford University, USA)
"Saving the Synapse: MHC Class I, Pruning and Plasticity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Inbal Benhar (Broad Institute of MIT and Harvard, USA)
"Systems Level Analysis of the Response to CNS Injury: Revealing Targets for Neuroprotection and Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Naomi Habib (Hebrew University of Jerusalem, Israel)
"Deciphering the Cellular Landscape of the Alzheimer's by Single Nucleus RNA-Seq"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Zsuzsanna Fabry (University of Wisconsin-Madison, USA) and Tika Benveniste (University of Alabama at Birmingham, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microglia and Other Glia Functions During Homeostasis and in Neurological Diseases
Discussion Leader: Frauke Zipp (University Medical Center, Johannes Gutenberg University Mainz, Germany)
7:30 pm - 7:50 pm
Marco Colonna (Washington University School of Medicine, USA)
"Impact of TREM2 in Microglia Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Marco Prinz (University of Freiburg, Germany)
"The Myeloid Side of the Brain"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Francisco Quintana (Brigham and Women's Hospital, USA)
"Environmental Control of CNS-Resident Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, USA)
"Impact of Immune Cells in Alzheimer's Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Effects on Brain Function
Discussion Leader: Tika Benveniste (University of Alabama at Birmingham, USA)
9:00 am - 9:20 am
Zsuzsanna Fabry (University of Wisconsin-Madison, USA)
"How Does Inflammation Alter Antigen Sampling from the Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Florent Ginhoux (Singapore Immunology Network, Singapore)
"Microglia Differentiation In Vivo and In Vitro "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Xianhua Piao (University of California, San Francisco, USA)
"Microglial GPR56 Regulates Developmental Synaptic Pruning"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: John Lukens (Center for Brain Immunology and Glia (BIG), University of Virginia, USA)
"DNA Damage Surveillance by the Innate Immune System in CNS Health and Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Margaret McCarthy (University of Maryland School of Medicine, USA)
"Microglia Mediate Masculinization of the Brain via Multiple Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Melanie Greter (University of Zurich, Switzerland)
"Cytokine Control of Brain Macrophage Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Michael Wheeler (Brigham and Women's Hospital, USA)
"Transcriptional Programs Underlying Astrocyte-Driven CNS Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Celia Shiau (University of North Carolina at Chapel Hill, USA)
"Brain Localized Inflammation Leads to Peripheral Tissue-Specific Macrophage Infiltration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Neurodegenerative Diseases
Session in memory of Ben Barres.
Discussion Leader: Beth Stevens (Boston Children's Hospital, USA)
7:30 pm - 7:50 pm
Li Gan (Gladstone Institutes / University of California, San Francisco, USA)
"How Microglia Dysfunction Contributes to Tauopathy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Michal Schwartz (Weizmann Institute of Science, Israel)
"Blocking Immune Checkpoint Signaling Pathways for Alzheimer's Disease Immunotherapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Frauke Zipp (University Medical Center, Johannes Gutenberg University Mainz, Germany)
"Immune-CNS Crosstalk: A Fine Line Between Injury and Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Tony Wyss-Coray (Stanford University School of Medicine, USA)
"Brain Vasculature as a Target of Circulatory Factors During Aging"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome-CNS Communication
Discussion Leader: Robyn Klein (Washington University School of Medicine in St. Louis, USA)
9:00 am - 9:20 am
Hartmut Wekerle (Max Planck Institute of Neurobiology, Germany)
"Brain Autoimmunity: Activation Events in Autoimmune T Cells Targeting the CNS"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jun Huh (Harvard Medical School, USA)
"Control of Neurodevelopmental Disorder by Maternal Bacteria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Naresha Saligrama (Stanford University, USA)
"From T Cell Receptor to Antigen: Systems Approaches to Discovering T Cell Antigen(s) in Neurological Diseases"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Leslie Kirby (Johns Hopkins School of Medicine, USA)
"Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rachel Caspi (National Eye Institute, NIH, USA)
"Regulation of Th17 by IL-17: Implications for Autoimmunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Sarkis Mazmanian (California Institute of Technology, USA)
"Gut-Microbiome-Brain Connections in Neurodevelopment"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Susanna Rosi (University of California, San Francisco, USA)
"Sex Specific Differences in Microglia Response to Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Arthur Liesz (Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany)
"Microbiota-Derived Short-Chain Fatty Acids Promote Amyloid Deposition via Microglial Activation in an AD Mouse Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
BBB and Other Barriers: Function and Dysfunction
Discussion Leader: Zsuzsanna Fabry (University of Wisconsin-Madison, USA)
7:30 pm - 7:50 pm
Katerina Akassoglou (Gladstone Institutes / University of California, San Francisco, USA)
"Fibrinogen in Neurological Diseases: From Mechanisms to Therapies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Dorian McGavern (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Immune Mechanisms Underlying Restoration of CNS Barriers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Berislav Zlokovic (Zilkha Neurogenetic Institute, University of Southern California, USA)
"Blood-Brain Barrier Structure, Function and Pathology: Implications for Dementia and Alzheimer's Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Daniel Reich (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Developing MRI Markers of Chronic Inflammation in Multiple Sclerosis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infections, Immunity and CNS
Discussion Leader: Irene Knuesel (Roche Innovation Center Basel, Switzerland)
9:00 am - 9:20 am
Beth Stevens (Boston Children's Hospital, USA)
"Understanding Microglia State Changes in Development and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jhimmy Talbot (Skirball Institute of Biomolecular Medicine, NYU Langone Health, USA)
"Enteric Neuron Function in Immune-Mediated Intestinal Barrier Protection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Celia Herrera-Rincon (Tufts University, USA)
"Brain-Bacteria Interface: A Brainless Xenopus laevis Developmental Model Reveals a Role for Brain in Regulating the Early Innate Immune Response"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Kristen Funk (Washington University School of Medicine, USA)
"CSFR1 Signaling Is Required for Local Restimulation of Antiviral CD8+ T Cells During Viral Encephalitis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Christopher Glass (University of California, San Diego, USA)
"Genome-Wide Approaches to Defining Human Microglia Identity and Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Susan Pierce (National Institute of Allergy and Infectious Diseases, NIH, USA)
"How Much Do We Need to Know About P. falciparum Cerebral Malaria to Treat It"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Jorge Alvarez (University of Pennsylvania, USA)
"CNS Intrinsic Mechanisms Suppressing T Cell Driven Neuroinflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Andrew Oberst (University of Washington, USA)
"ZBP1 and RIPK3 Induce an Antiviral Metabolic State in Neurons via IRG1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroimmunology Outside of CNS
Discussion Leader: Jonathan Kipnis (University of Virginia, USA)
7:30 pm - 7:50 pm
Isaac Chiu (Harvard Medical School, USA)
"Neuro-Immune Regulation of Bacterial Infection at Barrier Sites"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Asya Rolls (Technion - Israel Institute of Technology, Israel)
"Activating the Brain to Control Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Henrique Veiga-Fernandes (Fundação Champalimaud, Portugal)
"Neuronal Regulation of Innate Lymphocytes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Malu Tansey (University of Florida College of Medicine, USA)
"Progranulin Loss Dysregulates Splenic and Peripheral Blood Immune Cells Populations and May Contribute to Neuroinflammation and Neurodegeneration in Frontotemporal Dementia"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Nicole Lai (Harvard Medical School, USA)
"Sensory Neuronal Regulation of Enteric Host Defense Against Salmonella typhimurium "
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure