Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Emerging Topics in Neuroimmunology
This session will feature a keynote speaker, Nobel Laureate, Prof. Mario Capecchi.
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"The Presence of at Least Two Ontogenetic Distinct Microglia Populations in the Mammalian Brain"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Persistent Tri-Glial Dysfunction in Methotrexate Chemotherapy-Induced Neurological Impairment"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Power of ONE: Immunology in the Age of Single Cell Genomics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuroimmunology Beyond Microglia
9:00 am - 9:20 am
"Modulation of Neuroinflammation via Lymphatic Endothelial Growth Factor Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reversing Behavioral Abnormalities in Mice Exposed to Maternal Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Meningeal Lymphangiogenesis Effect on Malignancy of Glioblastoma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Mobilization of Meningeal Immune Cells Using Integrin Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Setting Some Boundaries: Neurodegeneration vs. Neuroinflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Saving the Synapse: MHC Class I, Pruning and Plasticity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Systems Level Analysis of the Response to CNS Injury: Revealing Targets for Neuroprotection and Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deciphering the Cellular Landscape of the Alzheimer's by Single Nucleus RNA-Seq"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microglia and Other Glia Functions During Homeostasis and in Neurological Diseases
7:30 pm - 7:50 pm
"Impact of TREM2 in Microglia Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Myeloid Side of the Brain"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Environmental Control of CNS-Resident Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Impact of Immune Cells in Alzheimer's Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Effects on Brain Function
9:00 am - 9:20 am
"How Does Inflammation Alter Antigen Sampling from the Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Microglia Differentiation In Vivo and In Vitro "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Microglial GPR56 Regulates Developmental Synaptic Pruning"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"DNA Damage Surveillance by the Innate Immune System in CNS Health and Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Microglia Mediate Masculinization of the Brain via Multiple Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cytokine Control of Brain Macrophage Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Transcriptional Programs Underlying Astrocyte-Driven CNS Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Brain Localized Inflammation Leads to Peripheral Tissue-Specific Macrophage Infiltration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Neurodegenerative Diseases
Session in memory of Ben Barres.
7:30 pm - 7:50 pm
"How Microglia Dysfunction Contributes to Tauopathy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Blocking Immune Checkpoint Signaling Pathways for Alzheimer's Disease Immunotherapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Immune-CNS Crosstalk: A Fine Line Between Injury and Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Brain Vasculature as a Target of Circulatory Factors During Aging"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome-CNS Communication
9:00 am - 9:20 am
"Brain Autoimmunity: Activation Events in Autoimmune T Cells Targeting the CNS"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Control of Neurodevelopmental Disorder by Maternal Bacteria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"From T Cell Receptor to Antigen: Systems Approaches to Discovering T Cell Antigen(s) in Neurological Diseases"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Th17 by IL-17: Implications for Autoimmunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Gut-Microbiome-Brain Connections in Neurodevelopment"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Sex Specific Differences in Microglia Response to Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Microbiota-Derived Short-Chain Fatty Acids Promote Amyloid Deposition via Microglial Activation in an AD Mouse Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
BBB and Other Barriers: Function and Dysfunction
7:30 pm - 7:50 pm
"Fibrinogen in Neurological Diseases: From Mechanisms to Therapies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Immune Mechanisms Underlying Restoration of CNS Barriers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Blood-Brain Barrier Structure, Function and Pathology: Implications for Dementia and Alzheimer's Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Developing MRI Markers of Chronic Inflammation in Multiple Sclerosis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infections, Immunity and CNS
9:00 am - 9:20 am
"Understanding Microglia State Changes in Development and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Enteric Neuron Function in Immune-Mediated Intestinal Barrier Protection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Brain-Bacteria Interface: A Brainless Xenopus laevis Developmental Model Reveals a Role for Brain in Regulating the Early Innate Immune Response"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"CSFR1 Signaling Is Required for Local Restimulation of Antiviral CD8+ T Cells During Viral Encephalitis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Genome-Wide Approaches to Defining Human Microglia Identity and Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"How Much Do We Need to Know About P. falciparum Cerebral Malaria to Treat It"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"CNS Intrinsic Mechanisms Suppressing T Cell Driven Neuroinflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"ZBP1 and RIPK3 Induce an Antiviral Metabolic State in Neurons via IRG1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroimmunology Outside of CNS
7:30 pm - 7:50 pm
"Neuro-Immune Regulation of Bacterial Infection at Barrier Sites"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Activating the Brain to Control Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Neuronal Regulation of Innate Lymphocytes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Progranulin Loss Dysregulates Splenic and Peripheral Blood Immune Cells Populations and May Contribute to Neuroinflammation and Neurodegeneration in Frontotemporal Dementia"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Sensory Neuronal Regulation of Enteric Host Defense Against Salmonella typhimurium "
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure