Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Co-Evolution of the Nervous and Immune Systems
Discussion Leader: Mario Capecchi (University of Utah School of Medicine, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Thomas Bosch (University of Kiel, Germany)
"Neurons Interact with the Microbiome: An Evolutionary-Informed Perspective"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Irene Salinas (University of New Mexico, United States)
"Neuroimmune Communication in the Teleost Olfactory-Brain Axis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Javier Irazoqui (UMass Chan Medical School, United States)
"Neural Regulation of Intestinal Innate Immunity in C. elegans "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Hannah Gordon (University of Notre Dame, United States)
"A Paradox Promoted by Microglia Cannibalism Shortens the Lifespan of Developmental Microglia"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Borders of Brain and CNS Lymphatics
Discussion Leader: Katerina Akassoglou (Gladstone Institutes, UCSF, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Zsuzsanna Fabry (University of Wisconsin-Madison, United States)
"Immunoregulatory Niche at the Meningeal Lymphatics Near the Cribriform Plate"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Berislav Zlokovic (Zilkha Neurogenetic Institute, University of Southern California, United States)
"Blood-Brain Barrier Link to Neurodegeneration, Cognitive Impairment and Alzheimer’s Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Zhongxiao Fu (University of Virginia, United States)
"Microglia Regulate Cerebral Blood Flow and Neurovascular Coupling"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Diana Bohannon (EVMS, United States)
"Neuroimmunological Implications of Altered Amyloid Beta Processing by a Subset of Microvascular Pericytes"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Chenghua Gu (Harvard Medical School, United States)
"Brain Vasculature at the Neuro-Immune Interface"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Francisco Garcia (MIT Department of Brain and Cognitive Sciences, United States)
"Single-Cell Dissection of the Human Brain Vasculature"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Simone Brioschi (Washington University in St. Louis, United States)
"A Novel Cre Line for Brain Macrophages Reveals Specific Features of Microglia and BAMs"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
John Lukens (Center for Brain Immunology and Glia (BIG), University of Virginia, United States)
"SYKO Mode: SYK is a Critical Orchestrator of Neuroprotective Microglial Responses in AD and MS"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Claudia Han (University of California, San Diego, United States)
"Gene Regulatory Networks Underlying Human Microglia Maturation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Beth Stevens (Boston Children's Hospital and Harvard Medical School, United States), Michelle Monje (Stanford University, United States) and Chenghua Gu (Harvard Medical School, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Micro- and Macroglia in Neurologic Disease
Discussion Leader: Beth Stevens (Boston Children's Hospital and Harvard Medical School, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Benjamin Deneen (Baylor College of Medicine, United States)
"Astrocyte Regulation of Brain Circuits"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Cagla Eroglu (Duke University Medical Center, United States)
"How Do Astrocytes Sculpt Neuronal Circuits in Health and Disease?"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Dorothy Schafer (University of Massachusetts Chan Medical School, United States)
"Immune Mechanisms Governing Microglia-Astrocyte Crosstalk and Synapse Remodeling"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Jonathan Kipnis (Washington University in St. Louis, United States)
"New Insights into Brain Macrophages"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Microbial Crosstalk with the Nervous System in Health and Disease
Discussion Leaders: Ashley Moseman (Duke University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Jun Huh (Harvard Medical School, United States)
"Maternal Gut Bacteria Underlies Both Neurodevelopmental and Immune-Primed Phenotypes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Francesca Odoardi (University Medical Center Göttingen, Germany)
"Functional Cross-Talk Between the Lung Microbiota and CNS Autoimmunity"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Madison Mix (University of Iowa, United States)
"Physiologic Microbial Exposure Expands Memory T Cell Surveillance of the Brain"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Sydney Labuzan (University of Virginia, United States)
"Investigating the Role of Microglial SYK in a Toxoplasma gondii Model of Neuroinflammation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Dorian McGavern (National Institute of Neurological Disorders and Stroke, NIH, United States)
"Microglial Maintenance of CNS Barriers"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Burkhard Becher (University of Zurich, Switzerland)
"The Paradox of IL-12 in Neuroprotection and Inflammation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Abigail Vanderheiden (Washington University in St Louis, United States)
"Memory Deficits After COVID-19 is Associated with Loss of Hippocampal Synapses and Neurogenesis in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Troy Trevino (University of Illinois at Chicago, United States)
"Wnt/ß-Catenin Suppression in Aging Exacerbates SARS-CoV-2-Induced Blood-Brain Barrier Disruption"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurological Effects of COVID-19
Discussion Leader: Marco Colonna (Washington University School of Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Stanley Perlman (University of Iowa, United States)
"Mouse Models for COVID-19 Neurological Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Michelle Monje (Stanford University, United States)
"Neural-Immune Interactions in Cognitive Impairment Following Cancer Therapy or COVID"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Michelle Erickson (University of Washington, United States)
"Interactions of SARS-CoV-2 Spike Proteins with the Blood-Brain Barrier"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Gregor Hutter (University Hospital Basel and University of Basel, Switzerland)
"Actionable Biomarkers for Neurocovid and Long Covid"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aging and Neurodegeneration
Discussion Leader: Aleksandra Deczkowska (Institut Pasteur, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, United States)
"Crossed Wires: How Alzheimer’s Disease Risk Genes Disrupt Neuron-glia Interactions"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Alison Goate (Icahn School of Medicine at Mount Sinai, United States)
"Alzheimer’s Disease Genetic Risk Alleles Implicate Efferocytosis in Microglia"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Himanish Basu (Harvard University, United States)
"Gasdermin-E Mediates Mitochondrial Damage in Axons and Neurodegeneration"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Jeremy Hill (Washington University School of Medicine, United States)
"Modulation of Peripheral Ly6CHi Monocytes Rescues Synapse Elimination During Recovery From ZIKV Encephalitis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jo Anne Stratton (McGill, Canada)
"Prodromal Parkinson’s Disease: Initiating Inflammatory Mechanisms Drive Neurological Damage"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Li Gan (Weill Cornell Medicine, United States)
"Hyperactive Antiviral Response Impairs Cognitive Resilience in Neurodegeneration"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Irene Bertolini (The Wistar Institute, United States)
"Role of Extracellular Vesicles in the Cross-Talk Between Microglia and Glioma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Lior Mayo (Tel Aviv University, Israel)
"Astrocyte Immunometabolic Regulation of the Tumor Microenvironment Drives Glioblastoma Pathogenicity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancers and Neuroimmune-Tumor Interactions
Discussion Leaders: Mirko HH Schmidt (TU Dresden, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Justin Lathia (Cleveland Clinic Foundation, United States)
"Sex-Specific Neural-Immune Interactions Impact Immune Suppression in the Glioblastoma Microenvironment"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Hideho Okada (University of California, San Francisco, United States)
"Glioma-Induced Neuronal Remodeling Promotes Regional Immunosuppression"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Milan Chheda (Washington University School of Medicine, United States)
"Zika Virus to Treat Glioblastoma"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Varun Venkataramani (University Clinic Heidelberg, Germany)
"Multicellular Networks in Brain Tumors"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
CNS Autoimmunity: An Expanding Disease Category
Discussion Leaders: Lior Mayo (Tel Aviv University, Israel)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Jennifer Gommerman (University of Toronto, Canada)
"B cells and CNS Inflammation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Weiquan (Wendy) Zhu (University of Utah, United States)
"Crosstalk Between Proinflammatory and EndoMT-Inducing Signaling Pathways Disrupts Blood-CNS Barrier Function and Promotes Progression of Neuroinflammatory Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Aakanksha Jain (Boston Children's Hospital, United States)
"Nociceptor Neuroimmune Interactomes Reveal Cell Type- and Injury-Specific Inflammatory Pain Pathways"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Stefan Bittner (University Medical Center Mainz, Germany)
"Regulatory T cells Recruit CNS Myeloid Cells to Counteract CNS Tissue Inflammation via a TGF-ß-CXCL10-CXCR3 Axis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Adam Denes (Institute of Experimental Medicine, Budapest, Hungary, Hungary)
"Compartment-Specific Modulation of Neuronal and Vascular Responses by Microglia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Adriano Aguzzi (University of Zurich, Switzerland)
"Pathogenesis of Prion Diseases: a Status Report"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Beatrice Wasser (University Medical Center Mainz, Department of Neurology, Germany)
"Modulation of Immune-Mediated Glutamatergic Pathways is Efficient to Counteract Neuroinflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Liwen Deng (Harvard Medical School, United States)
"Staphylococcus aureus Activates Pruriceptor Neurons and Drives Itch through a V8 Protease-PAR1 Axis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pain, Itch and Neuroimmunity
Discussion Leader: Nader Ghasemlou (Queen's University, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Dan Kaplan (University of Pittsburgh, United States)
"Control of Local Skin Inflammation by Cutaneous Sensory Afferents"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Diana Bautista (University of California, Berkeley/ HHMI, United States)
"Protease Signaling in Itch, Pain and Airway Inflammation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Tuan Trang (University of Calgary, Canada)
"Transcriptional Regulation of Microglia in Opioid Analgesia and Withdrawal"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Seog Bae Oh (Seoul National University, South Korea)
"Role of Natural Killer Cells in Peripheral Neuropathy and Chronic Pain"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure