| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome by Conference Chair David Ginty / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Neurotrophic Factors Signaling I |
| Discussion Leader: Carlos Ibanez (Karolinska Institute) |
| 7:40 pm - 8:05 pm | Barbara Hempsted (Cornell University)
"The diverse actions of proneurotrophins" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Larry Benowitz (Children’s Hospital/Harvard)
"Mst3b, a neuron-specific homolog of Ste20, mediates the effects of multiple growth factors on axogenesis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | David Kaplan (University of Toronto)
"The p53 family and neuronal survival death, and aged-related degeneration" |
| 9:15 pm - 9:25 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Neurotrophic Factors and Development I |
| Discussion Leader: Bill Snider (UNC) |
| 9:00 am - 9:25 am | Qiufu Ma (Dana-Farber Cancer Institute)
"Runx1 controls nociceptor subtype specification and innervation" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Sam Pfaff (Salk Institute)
"Gene regulation of motor neuron development and connectivity" |
|
10:00 am - 10:10 am | Discussion |
| 10:15 am | Group Photo |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Silvia Arber (University of Basel)
"Transcriptional specification of sensory-motor connectivity by peripheral
inductive signals" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Rudiger Klein (Max Planck Institute)
"Eph and Ret receptor signaling during axonal guidance and growth" |
| 11:45 am - 11.55 am | Discussion |
| 11: 55 am - 12:20 pm | Kuo-Fen Lee (Salk Institute)
"P75 as a co-receptor in neural development" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Neurotrophic Factors and Behavior |
| Discussion Leader: Moses Chao (NYU, Skirball) |
| 7:30 pm - 7:55 pm | Rene Hen (Columbia University)
"Neurogenesis and Depression" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Francis Lee (Cornell Medical School)
"Functional analysis of a genetic variant BDNF (Val66Met) mouse model" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Lisa Monteggia (UT Southwestern)
"Role of BDNF in Neuropsychiatric Disorders" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Yun Li (UT Southwestern) Short talk
"TrkB regulates hippocampal neurogenesis and governs sensitivity to
antidepressive treatment" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:15 pm | Neurotrophic Factors and Plasticity I |
| Discussion Leader: Yves Alain Barde (University of Basel) |
| 9:00 am - 9:25 am | Mike Ehlers (Duke University)
"Positioning Endocytic Machinery in Dendrites and Spines" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Nancy Ip (Hong Kong University)
"Regulation of synapse development by receptor tyrosine kinase signaling" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Bai Lu (NIMH)
"Yin-Yang hypothesis: opposing roles of pro- and mature BDNF in synapse development and plasticity" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Martha Constantine-Paton (Yale University)
"NMDA receptors BDNF Traffic PSD-95 to Visual Synapes" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | James McNamara (Duke University)
"TrkB and Epileptogenesis: In Search of an Ounce of Prevention" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Neurotrophic Factors and Neurological Disorders I |
| Discussion Leader: Rosalind Segal (Children’s Hospital/Harvard) |
| 7:30 pm - 7:55 pm | Frank Longo (Stanford University)
"Small Molecule neurotrophin receptor ligands" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Jeff Kordower (Rush Medical School)
"Gene therapy for Parkinson’s disease: Preclinical and clinical studies" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Kevin Jones (Univ. of Colorado, Boulder)
"Expression Profiling of Animal Models Supports a Link Between BDNF Loss and Huntington's Disease" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Alexander Parsadanian (Washington University) Short Talk
"Neuroprotective effects of transgene GFLs in mouse models of motoneuron and motor axon degeneration" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:20 pm | Neurotrophic Factors and Development II |
| Discussion Leader: Story Landis (NIH) |
| 9:00 am - 9:25 am | Tom Jessell (Columbia University)
"Sensory-Motor Circuit Assembly in the Spinal Cord" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Tony Pawson (University of Toronto)
"The Nck SH2/SH3 adaptor protein in the guidance of spinal cord neurons" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:35 am | Coffee Break |
| 10:35 am - 11:00 am | Fan Wang (Duke University)
"Retrograde BMP signaling regulates somatosensory neuron differentiation and somatosensory map formation" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Gabriel Corfas (Children’s Hospital/Harvard)
"Neuregulin-Erb signaling in oligodendrocytes" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:10 pm | Steve Burden (Skirball Institute)
"MuSK controls the position of motor axons and synapses in muscle" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Neurotrophic Factors and Neurological Disorders II |
| Discussion Leader: Susan Meakin (Robarts Research Institute) |
| 7:30 pm - 7:55 pm | Erika Hozbaur (University of Pennsylvania)
"Cytoplasmic dynein function and dysfunction in axonal transport" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Yamin Yang (Stanford University)
"Transport defects in the pathogenesis of neurodegeneration" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Jack Griffin (JHU)
"Roles of Trk signaling in the adult PNS" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | David Katz (Case Western University)
"Dysregulation of BDNF Expression and Neurosecretion in a Mouse Model of Rett Syndrome" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:15 pm | Neurotrophic Factor Signaling II |
| Discussion Leader: Louis Reichardt (UCSF) |
| 9:00 am - 9:25 am | Enrico Tongiorgi (University of Trieste)
"Trafficking and cellular effects of BDNF isoforms" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Gary Landreth (Case Western University)
"Erk2 signaling in the adult cortex" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:35 am - 10:55 am | Bruce Carter (Vanderbilt University)
"Mechanisms of apoptotic signaling by p75" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Mark Bothwell (University of Washington)
"Trk transactivation fragments the neuronal Golgi complex" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Lino Tessarollo (NCI)
"Conserved residues that modulate Trk signaling in vivo" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Neurotrophic Factors and Plasticity II |
| Discussion Leader: Hermes Yeh (Dartmouth) |
| 7:30 pm - 7:55 pm | Andres Buonanno (NIH)
"Neuregulins Depotentiate LTP at Glutamatergic Synapses: Possible Implications in Schizophrenia"
|
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Patricia Salinas (University College, London)
"Wnts and transynaptic signaling" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Shumin Duan (Chinese Academy of Sciences)
"Turning on presynaptic silent synapses by BDNF-CDC42 signaling" |
| 9:05 pm - 9:15 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
