Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Neurotrophin Signaling Mechanisms
Discussion Leader: Michael Greenberg (Harvard Medical School, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Carlos Ibanez (Karolinska Institute, Sweden)
"Mechanism-Based Pharmacology of the p75 Neurotrophin Receptor"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Fernanda Ledda (University of Buenos Aires, Argentina)
"Pea3 Transcription Family Members and Neuronal Differentiation in Response to Neurotrophins"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Rejji Kuruvilla (Johns Hopkins University, USA)
"Axonal Targeting Mechanisms for Neurotrophin Receptors"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurotrophin Effects on Nervous System Development
Discussion Leader: Barbara Hempstead (Weill Cornell Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:50 am
Alexander M. Cruickshank Lecture: Liqun Luo (Stanford University, USA)
"Neurotrophin Signaling in Competitive Dendrite Morphogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Elizabeth Coulson (University of Queensland, Australia)
"Regulation of Cholinergic Basal Forebrain Function and Dysfunction by p75"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
Lauren Orefice (Harvard Medical School, USA)
"Development and Organization of Low-Threshold Mechanosensory Neurons"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Lloyd Greene (Columbia University, USA)
"What Is ATF4 Doing in the Brain and Why Should Neurotrophiners Care?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Rosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Plasticity
Discussion Leader: Moses Chao (New York University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Martin Korte (TU Braunschweig, Germany)
"Role of Ligand-Independent TrkB Transactivation
in Controlling Dendritic Architecture of Interneurons, Granule Cells and Pyramidal Neurons"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Martha Escobar (Autonomous University of Mexico, Mexico)
"Neurotrophins
in Plasticity and Metaplasticity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Marco Canossa (European Brain Research Institute (EBRI), Italy)
"Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Neurotrophic Factors in Disease
Discussion Leader: Lloyd Greene (Columbia University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Helen Scharfman (Nathan Kline Institute, New York University, USA)
"The Role of BDNF in Epilepsy"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
William Mobley (University of California, San Diego, USA)
"Neurotrophins and Neurodegenerative Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Cheryl Dreyfus (Robert Wood Johnson Medical School, Rutgers University, USA)
"Enhancing Recovery from a Demyelinating Lesion Through the Actions of BDNF: The Role of Astrocytes and Metabotropic Glutamate Receptors"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Michael Sendtner (University of Wuerzburg, Germany)
"Altered Axonal Actin Dynamics in Spinal Muscular
Atrophy and Amyotrophic Lateral Sclerosis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Patrick Mantyh (University of Arizona Cancer Center, USA)
"NGF and Skeletal Pain"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intracellular Trafficking and Local Signaling
Discussion Leader: Francisca Bronfman (Pontificia Universidad Catolica de Chile, Chile)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Giampietro Schiavo (University College London, United Kingdom)
"Functional Characterisation of Axonal Signalling Endosomes in Motor Neurons"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Enrico Tongiorgi (University of Trieste, Italy)
"Spatial and Quantitative Regulation of Local BDNF
Synthesis in Dendrites"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jeffery Twiss (University of South Carolina, USA)
"Signaling to Stress Granules Alters Axon Regeneration"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Mechanisms of Neurotrophin Function
Discussion Leader: Mark Bothwell (University of Washington, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Anton Maximov (The Scripps Research Institute, USA)
"Intrinsic Assembly of Excitatory Circuits"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Tonis Timmusk (Tallinn University of Technology, Estonia)
"Regulation
of BDNF Gene Transcription and Translation in Neuronal and Non-Neuronal Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Mollie Meffert (Johns Hopkins University School of Medicine, USA)
"Post-Transcriptional Control of Trophic
Responses"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Mladen-Roko Rasin (Robert Wood Johnson Medical School, Rutgers University, USA)
"Ribosome Signature, RNA Binding Proteins and Trophic Factors in Neurogenesis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Lino Tessarollo (National Cancer Institute, NIH, USA)
"Physiological Roles and Signaling of Truncated
Trk Receptors"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Neurotrophins and Behavior
Discussion Leader: Louis Reichardt (Simons Foundation, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Thomas Carew (New York University, USA)
"Using a Simple System to Explore a Complex Question: The Role(s)? of Growth Factor Signaling in Memory Formation in Aplysia"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Francis Lee (Weill Cornell Medicine, USA)
"Neurotrophic Factors and OCD-Like Phenotypes"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Eero Castren (University of Helsinki, Finland)
"TrkB Signaling Activated by Drugs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Axonal Growth, Degeneration and Signaling
Discussion Leader: Bruce Carter (Vanderbilt University School of Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Mike Fainzilber (Weizmann Institute of Science, Israel)
"Acting Locally to Grow Globally – Localized Mechanisms in Neuron Growth Regulation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Rosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA)
"RNA Transport Granules and Axonal Degeneration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Eran Perlson (Tel Aviv University, Israel)
"Spatial Effect of Neurotrophic Factors on Motoneuron Health"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
David Simon (Stanford University, USA)
"Control of Sensory Axon Degeneration
by the Neuronal Cell Body"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Avraham Yaron (Weizmann Institute of Science, Israel)
"Mechanisms
of Axonal Pruning"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stem Cell Regulation by Neurotrophic Factors
Discussion Leader: David Kaplan (Hospital for Sick Children, Canada)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Freda Miller (University of Toronto, Canada)
"Growth Factors and Cell Genesis in the Developing Mammalian Brain"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Armen Saghatelyan (Laval University, Canada)
"Neuronal Migration and Maturation in the Adult Brain"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Lee Rubin (Harvard University, USA)
"Using Stem Cells to Model and Treat Neurodegenerative Disease"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure