Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Keynote Talk by Dr. Lauren Orefice
Discussion Leader: Alejandra Fernandez (Oregon Health and Science University, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:25 pm
Lauren Orefice (Massachusetts General Hospital /Harvard Medical School, United States)
"Understanding Somatosensory Circuit Alterations in Autism Spectrum Disorder"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sensory Signaling, Physiology, and Circuit Development
Discussion Leader: Oscar Marcelo Lazo (University College London, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Emma Lloyd (University College London, United Kingdom)
"Investigating the Spatial Regulation of Protein Synthesis in Adult Sensory Neurons During Homeostasis and Regeneration"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Eric Villalón Landeros (Johns Hopkins University School of Medicine, United States)
"The Nociceptive Activity of Peripheral Sensory Neurons is Modulated by the Neuronal Membrane Proteasome"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Alejandra Fernandez (Oregon Health and Science University, United States)
"Pten Signaling Drives Primary Sensory Neuron Population Diversification"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Emily Scott-Solomon (Harvard University, United States)
"The Root of Hair Loss: Nerves, Immune Cells, and Stem Cells in Stress Induced Alopecia"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Lauren Miller (Oregon Health & Science University, United States)
"Role of Retrograde Neurotrophic Factor Signaling During Mechanosensory Circuit Formation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Pia Boxy (Danish Research Institute of Translational Neuroscience (DANDRITE), Denmark)
"Single-Chain SorCS2 Impairs Cerebellar Morphology and Connectivity: Implications for Cognitive and Motor Function"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Lily Quach (Oakland University William Beaumont School of Medicine, United States)
"Antiferromagnetic Auto-Oscillators as Artificial Neurons: A Platform for Neuromorphic Computing and Physiological Modeling"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Neurotrophic Factor Cell Biology
Discussion Leader: Lily Quach (Oakland University William Beaumont School of Medicine, United States)
9:00 am - 9:10 am
Marousa Darsinou (University College London, United Kingdom)
"Identification of the RNA Binding Proteins that Regulate Tp53inp2 mRNA Function in Neurons"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Braulio Martinez (UCL, United Kingdom)
"Local Control of Axonal Translation During Neuronal Development by N6-methyladenosine (m6A) Methylation of Long 3-UTRs"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Guillermo Moya (Johns Hopkins University, United States)
"Axonal targeting of membrane protein by transcytosis"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Reynaldo Tiburcio Felix (Universidad Andrés Bello, Chile)
"BDNF-Dependent Translational Control of Signaling Endosomes in Axons of Cortical Neurons"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Keeley Spiess (University of North Carolina - Chapel Hill, United States)
"Apoptosis in Neurons: Transient and Reversible"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Jose Norberto (Jobert) Vargas (UCL- Institute of Neurology; UK Dementia Research Institute, United Kingdom)
"BDNF Remodels the Phosphorylation Network of Cytoskeletal Effectors in iPSC-derived Human Motor Neurons"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Julia Zbiegly (UK Dementia Research Institute, University of Cambridge, United Kingdom)
"The TrkB Protein Interactome Changes from Embryonic State to Adulthood and Displays Specific Changes in a Prion Mouse Model for Neurodegeneration"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Oscar Marcelo Lazo (University College London, United Kingdom)
"Anterograde Delivery of Rab10-organelles Regulates the Sorting of Internalised TrkB for Retrograde Axonal Transport: A Matter of Flexibility"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Neurotrophic Mechanisms in Disease and Therapeutics
Discussion Leader: Srestha Dasgupta (Rutgers University-Newark, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 1:45 pm
Giulia Borgonovo (Bio@SNS, Scuola Normale Superiore, Italy)
"Exploring the Contribution of Microglial NGF-TrkA Signaling in Health and Disease"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:00 pm
Maria Anna Papadopoulou (University of Crete, Medical school, Greece)
"The Pan-Neurotrophin Receptor p75NTR and its Effects in Adult Neurogenesis and Human Neural Stem Cells: A Novel Therapeutic Target Against Alzheimer’s Disease"
2:00 pm - 2:05 pm
Discussion
2:05 pm - 2:15 pm
Ellie Rhymes (Department of Neuromuscular Diseases, University College London, United Kingdom)
"Optimising AAV-BDNF Gene Therapy in Mouse Models of Charcot Marie Tooth Disease Type 2D."
2:15 pm - 2:20 pm
Discussion
2:20 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes