SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome: Bob Hancock, Chair (University of British Columbia) / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | The Picture Today and Tomorrow - Keynote Addresses |
7:35 pm - 7:45 pm | Discussion Leader: Trevor Trust (Astra Zeneca) |
7:45 pm - 8:30 pm | Julian Davies (University of British Columbia) "Resistance: Lessons to learn" |
8:30 pm - 9:15 pm | Karen Bush (Johnson and Johnson) "What is in the future for antibiotics?" |
9:15 pm - 9:30 pm | General Discussion |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Conventional Targets |
| Discussion Leader: Lynn Silver (LL Silver Consulting) |
9:00 am - 9:25 am | Prabhavathi Fernandes (Cempra Pharmaceuticals Inc) "What makes a good antibiotic target" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Roy Kishony (Harvard) "Antibiotic interactions to discourage resistance development" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Hans Georg Sahl (U. Bonn) "Cell Walls as a target" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break / Group Photo |
11:20 am - 11:45 am | Ann Eakin (Astra Zeneca) "DNA synthesis as a target" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Roger C. Levesque (U. Laval) "Cell Division as a target" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:15 pm | Poster Session 1 |
5:30 pm - 7:30 pm | Screening Strategies and Hit Generation |
| Discussion Leader: Tim Falla (Helix Biomedix) |
5:30 pm - 5:55 pm | Jay Hinton (Inst. Food Research, UK) "Differences between in vitro and in vivo lifestyle" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Dieter Habich (Bayer) "Reversed genomics and chemical post-evolution of natural products - Sources for new antibacterials" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Jennifer Leeds (Novartis) "New screening strategies" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Selected Poster Talk: Jonathan Swoboda (Harvard Medical School)
"Genetic analysis of Staphylococcus aureus Wall Teichoic Acid (WTA) biosynthesis and an in vivo high throughput screen for inhibitors targeting this pathway" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:15 pm - 11:00 pm | Poster Session 1 (continued); Beverages available |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Alternative Antibacterial Approaches |
| Discussion Leader: William Shafer (Emory U. School of Medicine) |
9:00 am - 9:25 am | James Mond (BioSynexus) "Therapeutic Antibodies" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Oreola Donini (Inimex Pharma)
"Selective Immunomodulators" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Vincent Fischetti (Rockefeller University) "Using phage lytic enzymes to control pathogenic bacteria" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:25 am | Coffee Break |
11:25 am - 11:50 am | Alan Bocking (Mt. Sinai Hospital) "Probiotics and Perinatal Health" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected Poster Talk: Anna Maria Pirttila (University of Oulu)
"Endophytic fungi as a source of new antimicrobials" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected Poster Talk: Elizabeth Moritz (University of Illinois)
"The prevalence of toxin-antitoxin systems in clinical isolates and investigation into their tractability as novel antimicrobial targets" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:15 pm | Poster Session 2 |
5:30 pm - 6:30 pm | Pre-Clinical and Clinical Considerations |
| Discussion Leader: Julian Davies (University of British Columbia) |
5:30 pm - 5:55 pm | John Rex (Astra Zeneca) "Clinical considerations for a new antibiotic" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:25 pm | Keith Rodvold (PharmD) "Infection site antibiotic concentrations and their meaning" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 7:30 pm | Cell Division and Antibiotic Signatures |
6:30 pm - 6:40 pm | Selected Poster Talk: Remco Kort (TNO Quality of Life)
"The fingerprints that antibiotics leave in the transcriptome of Staphylococcus aureus" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Selected Poster Talk: Elizabeth Harry (University of Technology Sydney)
"Targeting cell division: The Z Ring assembles from a dynamic helical-like structure" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Selected Poster Talk: Neil Stokes (Prolysis Limited)
"CDI-936 series of novel cell division inhibitors with potent and selective anti-staphylococcal activity" |
7:10 pm - 7:15 pm | Discussion |
8:00 pm | Dinner |
9:15 pm - 11:00 pm | Poster Session 2 (continued); Beverages available |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Gram Negative Active Drugs |
| Discussion Leader: Laura Piddock (Birmingham Medical School) |
9:00 am - 9:25 am | Matthew E. Falagas (Alfa Institute of Biomedical Sciences) "Revival of the Polymyxins" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Tim Falla (Helix Biomedix) "The evolution of the innate immunity antibiotic" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Dirk Buman (Hannover Medical School) "Identifying new targets for Salmonella through in vivo screening" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:25 am | Coffee Break |
11:25 am - 11:50 am | Natalie Strynadka (Univ of British Columbia) "Structural biology approaches to understanding antibiotic mechanisms and resistance" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected Poster Talk: Kristen Schurek (University of British Columbia)
"Identification of novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected Poster Talk: Ruslan Tsivkovski (MPEX Pharmaceuticals)
"Efflux pump inhibitors (EPIs): Multiple ways to inhibit a single pump" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:15 pm | Poster Session 3 |
5:30 pm - 7:30 pm | Novel Targets and Overcoming Resistance |
| Discussion Leader: Jared Silverman (Cubist Pharmaceuticals) |
5:30 pm - 5:55 pm | Patricia Bradford (Wyeth) "Where are we with Resistance?" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:25 pm | Sheo Singh (Merck) "New strategies to develop novel targets: Platensimycin, a selective FabF inhibitor" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Satoshi Murakami (Institute of Scientific and Industrial Research, Osaka University) "Structure and mechanism of bacterial multi-drug efflux systems" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | Eric Brown (McMaster U) "Probing uncharted physiology in bacteria with new (and old) small molecules" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
9:15 pm - 11:00 pm | Poster Session 3 (continued); Beverages available |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:10 am | Selected Topics & Late Breakers |
| Discussion Leaders: Patrice Courvalin (Institut Pasteur) |
9:00 am - 10:40 am | Selected Topics and Late Breakers: Attendees are invited to discuss topics of interest in less than 5 minutes with 5 slides (strictly regulated). Presenters will be selected at the Gordon Conference by the Chair. |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:30 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
11:30 am - 12:30 pm | Recent Experience with Clinical Trials |
| Discussion Leader: Patricia Bradford (Wyeth) |
11:30 am - 11:55 am | Jutta Heim (Basilea) "Anti-resistance; ceftobiprole, an anti-MRSA broad-spectrum cephalosporin antibiotic" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Bruce Montgomery (Gilead Sciences) "Inhaled antibiotics" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time |
5:30 pm - 7:30 pm | Towards More Efficient Antibacterial Development |
| Discussion Leader: Keith Poole (Queens U) |
5:30 pm - 5:55 pm | Jacques Schrenzel (U Hospitals Geneva) "Combined proteomics and transcriptomics approach for the identification of resistance-related markers: glycopeptide-resistance in Staph. aureus" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Rod Hubbard (York U) "Fragment-based drug discovery" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Rudolf Then (Consultant) "Multiple mode of action antibiotics: some lessons from nature and application in antibiotic design" |
7:05 pm - 7:15 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |