SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Co-Chairs |
7:40 pm - 9:30 pm | KEYNOTE ADDRESSES |
| Discussion Leader: Trevor Trust (AstraZeneca Boston) |
7:40 pm - 8:25 pm | Roberto Kolter (Harvard Medical School) "Microbial Chemical Ecology and the Future of Antibiotics" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Christopher A. Lipinski (Scientific Advisor, Melior Discovery, Inc.) "Bridging the Gap Between Academic Drug Discovery and Development" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | MULTIDRUG RESISTANCE |
| Discussion Leader: Jennifer Leeds (Novartis Institutes for Biomedical Research) |
9:00 am - 9:30 am | Keith Poole (Queens University, Canada) "Multidrug efflux systems as components of stress responses in Pseudomonas aeruginosa: implications for in vivo recruitment of efflux mechanisms and promotion of multidrug resistance" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk: M. Stephen Trent (University Of Texas) "A link between membrane assembly and bacterial locomotion in Campylobacter jejuni" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Shahriar Mobashery (University of Notre Dame) "The BlaR Protein and Its Involvement in Methicillin-Resistance in Staphylococcus aureus" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Olga Lomavskaya (MPEX Pharmaceuticals) "Bacterial Multidrug Resistance Pumps as Targets for Inhibitors" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk: Amrita Bharat (McMaster University) "Targeting bacterial ribosome biogenesis by inhibition of the essential GTPase EngA" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk: Bernard Weisblum (University Of Wisconsin) "Screen for compounds that induce autolysis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PHARMCODYNAMICS MATTERS |
| Discussion Leader: Sujata Bhavnani (Institute for Clinical Pharmacodynamics) |
7:30 pm - 8:00 pm | David Melnick (Astra Zeneca) "Use of Pharmacodynamics in Early Antibiotic Lead Optimization" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Juergen Bulitta (University at Buffalo, Ordway Research Institute) "Mechanism-Based Approach to Combination Antimicrobial Chemotherapy" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David D’Argenio (University of Southern California, Biomedical Engineering) "New Mathematical Approaches for Pharmacodynamics" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW DRUGS FOR BAD BUGS |
| Discussion Leader: Gary Noel (Johnson and Johnson PRD) |
9:00 am - 9:30 am | Lou Rice |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ken Coleman (Novexel Pharmaceuticals) "Impact of a New, Broad Spectrum β-lactamase Inhibitor" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Poster Talk: Heike Broetz-Oesterhelt (University Of Duesseldorf) "Structures of bacterial ClpP in complex with a novel class of acyldepsipeptide antibiotics reveal its activation mechanism" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | John Bruss (Achaogen) "The Aminoglycosides: They’re BAAAAACK" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Jian Li (Monash University, Australia) "Optimal Use of Colistin for the Treatment of MDR Gram-negative Pathogens" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ANTIBACTERIAL DRUG DEVELOPMENT: WHAT WENT WRONG? |
| Discussion Leader: W. Michael Scheld (University of Virginia) |
7:30 pm - 7:55 pm | Tom Parr (The Medicines Company) "Impact of Regulatory Uncertainty on Drug Development-Industrial Perspective" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Zuoyu Xu (NIAID) "We’re NIAID and We’re in the Game" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Edward Cox (FDA) "Regulatory Uncertainty: The Regulator’s Perspective" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Robert Guidos (Infectious Diseases Society of America (IDSA) "The 10 X '20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW BIOLOGY |
| Discussion Leader: Stephen Trent (University of Texas, Austin) |
9:00 am - 9:30 am | Claire Poyart (Pasteur Institute) |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk: Jeffrey Schertzer (University Of Texas) "Characterization of an Oxygen-Sensitive Switch Controlling P. aeruginosa Virulence" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Marvin Whitely (University of Texas, Austin) "Using bacterial 'lobster traps' to study antibiotic resistance" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Chris Whitfield (University of Guelf) "Biosynthesis and export of bacterial lipopolysaccharides" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk: Steven Firestine (Wayne State University) "Studies on a novel membrane targeted antibiotic" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk: Jennifer Campbell (Harvard Medical School - Dept Of Microbiology) "Discovery and evaluation of Staphylococcus aureus wall teichoic acid biosynthesis inhibitors" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | NEW CHEMISTRY |
| Discussion Leader: Stew Fisher (Astra Zeneca) |
7:30 pm - 8:00 pm | Justin Nodwell (McMaster University) "Activation of secondary metabolite production by genetic and chemical manipulation of Streptomyces spp" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Brian Bachmann (Vanderbilt University) "New Methods for the Discovery of Antimicrobial Natural Products from Hypogean Ecosystems" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Caren Meyers (Johns Hopkins University, School of Medicine) "Targeting Non-Mammalian Isoprenoid Biosynthesis" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW APPROACHES TO ANTIBACTERIAL DRUG DISCOVERY |
| Discussion Leader: Karen Bush (University of Indiana) |
9:00 am - 9:30 am | Jared Silverman (Cubist Pharmaceuticals) "A History of the Development of Daptomycin: From Bedside to Bench and Back Again" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Poster Talk: Shailendra Sonawane (Piramal Life Sciences Ltd) "Protoplast fusion of marine actinomycetes as a tool to discover new bioactive leads" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Bob Hancock (University of British Columbia) "Innate Defence Regulators as a new anti-infective strategy" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Terry Roemer (Merck Research Laboratories) "An Antisense-based Genetic Potentiation Strategy to Restore Antibiotic Susceptibility against MRSA" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk: Richard Lee (St Jude Children's Research Hospital) "Novel spectinomycin analogs as anti-tubercular agents" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk: Bruce Maguire (Pfizer Inc) "The development of a robust industrial crystallography program for structure based design of antibiotics acting on the 50S ribosomal subunit" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW APPROACHES TO ANTIBACTERIAL DRUG DEVELOPMENT |
| Discussion Leader: Ken Bartizal (Trius Therapeutics) |
7:30 pm - 8:00 pm | Paul Ambrose (Institute for Clinical Pharmacodynamics) "Have We Actually Been Able to Link Exposure to Response?" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Keith Rodvold (University of Illinois at Chicago, School of Pharmacy) "Penetration of Antimicrobials into ELF: Impact on Outcome in Pneumonia Trials" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Francoise Van Bambeke (Catholic Universite Louvain) "Intracellular Killing: Where’s the Bug?/Where’s the Drug?" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |