SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Resistance and the Gram Positive Cell Wall |
| Discussion Leader: Jennifer Leeds (Novartis) |
7:40 pm - 8:20 pm | Patrice Courvalin (Institute Pasteur)
"Antibiotics Are Self-Destructive"
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8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Alexander Tomasz (Rockefeller University)
"From Gene to Phenotype: New Genetic Determinants and Biochemical Mechanisms that Define the Antibiotic Resistant Phenotype in MRSA"
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9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Preclinical: Novel Approaches |
| Discussion Leader: Alex O'Neill (University of Leeds) |
9:00 am - 9:30 am | Marvin Miller (Notre Dame)
"Design, Syntheses and Studies of New Antibiotics and Selective Anti-TB agents"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Vanessa Sperandio (UT Southwestern)
"QseC Small Molecule Inhibitors as an Anti-Virulence Strategy Against Gram-Negative Pathogens"
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10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Erin Carlson (Indiana University)
"Small Molecule Inhibitors of Histidine Kinase Activity"
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11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Vincent Fischetti (Rockefeller University)
"Development of Epimerox, a Novel Compound with Reduced Resistance Potential to Treat Gram-Positive Bacterial Infections"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk: Ruben Tommasi (AstraZeneca)
"Improving Our Understanding of Porin Permeability in Gram-Negative Bacteria" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Reactive Oxygen Species in Antibiotic Mechanism |
| Discussion Leader: Daniel Ritz (Actelion) |
7:30 pm - 8:00 pm | Dan Dwyer (Boston University)
"Bactericidal Antibiotics, Metabolic Alterations and Reactive Oxygen Species"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kim Lewis (Northeastern University)
"Bactericidal and Sterilizing Antibiotics: How They Kill Regular and Dormant Cells"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Greg Somerville (University of Nebraska)
"Bacterial Cultivation and Antibiotic Susceptibility in Staphylococcus aureus"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Preclinical: Taking Aim at Resistance |
| Discussion Leader: Man-wah Tan (Genentech) |
9:00 am - 9:30 am | Deb Hung (Broad Institute)
"Killing More Bugs: Is This the Best That We Can Do?"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Terry Roemer (Merck)
"Chemical Genetic Strategies to Restoring MRSA Susceptibility to β-Lactam Antibiotics"
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10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Paul Hergenrother (University of Illinois)
"Small Molecules that Specifically Kill Fluoroquinolone-Resistant Bacteria"
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11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Christian Melander (North Carolina State University)
"Small Molecule Suppression of Antibiotic Resistance by Targeting Bacterial Two Component Systems"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk: Eleanor Allen (Stony Brook University)
"Translating Slow-Binding Inhibition Kinetics into Cellular and In Vivo Effects" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Microbiome - Opportunities and Challenges |
| Discussion Leader: Eric Pamer (Sloan-Kettering) |
7:30 pm - 8:00 pm | Michael Surette (McMaster University)
"The Challenge of Polymicrobial and Chronic Infections: Separating Friend from Foe"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Henry Haiser (Harvard University)
"Predicting and Manipulating Drug Inactivation by the Human Gut Microbiome"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Laura Cox (NYU)
"The Role of Early-Life Antibiotic Exposure in Shaping Adult Body Composition"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Clinical Update: Experience with New Regulatory Pathways |
| Discussion Leader: Alita Miller (AstraZeneca) |
9:00 am - 9:30 am | Nestor Molfino (KaloBios)
"Clinical Development of an Anti-Pseudomonas aeruginosa Type III Secretion System Antibody in Respiratory Diseases"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Mary Celine Scott (Trius/Cubist)
"Clinical Development of Tedizolid Phosphate - Executing an ABSSSI/cSSTI Phase 3 Program in the Global Regulatory Landscape"
|
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Lynn Connolly (Achaogen)
"Clinical Development of Plazomicin, a Next-Generation Aminoglycoside, for Serious Infections Due to Multidrug Resistant Enterobacteriaceae"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | John O'Donnell (AstraZeneca)
"Avibactam Combinations in the Clinic"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk: John Alumasa (Pennsylvania State University)
"Exploiting the Potential of Trans-Translation to Identify Molecular Targets for New Classes of Lead Antibiotic Candidates" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Public-Private Partnerships to Advance Antibacterial Discovery |
| Discussion Leader: Nicole Mahoney (Pew Charitable Trusts) |
7:30 pm - 8:00 pm | Angela Wittelsberger (Innovative Medicines Initiative)
"Public-Private Partnership to Address the Threat of Antimicrobial Resistance: The Innovative Medicines Initiative's ND4BB Programme"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Debra Hanna (Critical Path Institute)
"Critical Path to TB Drug Regimens: A Successful Consortium Model for Innovation"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Ann Eakin (NIH)
"NIAID Preclinical and Clinical Resources to Facilitate Antibacterial Development"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Poster Talk: Danielle Demers (University of South Florida)
"An Epigenetics Based Fungal Metabolite Screening Program for Antibacterial Lead Compounds" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Resistance: Mechanisms and Detection |
| Discussion Leader: Heike Brötz-Oesterhelt (University of Dusseldorf) |
9:00 am - 9:30 am | Lori Burrows (McMaster University)
"Novel Phenotypes Revealed by 'Ineffective' Antibiotic Concentrations"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Juan Hermoso (Inst. Rocasolano. Spanish National Research Council)
"Structural Basis of Allosteric Mechanism Controlling Antibiotic Resistance in PBP2a from MRSA"
|
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Gautam Dantas (Washington University)
"Networks of Exchanging Antibiotic Resistance in Human-Associated and Environmental Bacteria"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Michael Hodsdon (Yale University)
"Rapid Detection of Carbapenemase Activity in Clinical Specimens by Mass Spectrometry"
|
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | TBA (Late-Breaking Topic Talk) |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Resistance: Combinations to Fight Resistance |
| Discussion Leader: Arnold Bayer (UCLA School of Medicine) |
7:30 pm - 8:00 pm | Ann Kwong (InnovaTID)
"Lessons Learned from the Use of Combinations in HCV"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Khisi Mdluli (Global Alliance for TB Drug Development)
"Pre-Clinical and Clinical Development of Regimens that Shorten the Duration of TB Therapy and Eliminate Drug Resistance"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Victor Nizet (University of California, San Diego)
"Adjunctive Antibiotic Therapy to Enhance Endogenous and Administered Peptide Antibiotics: From Bedside to Bench"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |