Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Critical Lessons of the Past and Their Application to Modern Antibacterial Drug Discovery and Development
Discussion Leader: Karen Bush (Indiana University Bloomington, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 8:40 pm
Christopher Walsh (Stanford University, USA)
"Scaffold Complexity Generation by Tailoring Enzymes in Natural Product Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Patricia Bradford (Antimicrobial Development Specialists, LLC, USA)
"Development and Approval Pathway for Ceftazidime-Avibactam: A Step Towards Tailoring Programs to Address Antibiotic Resistance"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Clinical Reality – Single Agent Therapeutics and Antibacterial Drug Resistance: Examining the Need for New Therapeutic Options in the Clinic
Discussion Leader: David Shlaes (Anti-Infectives Consulting (retired), USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Louis Rice (Brown University, USA)
"Pushing the Envelope: Multi-Resistance in Gram-Negative Bacteria"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Romney Humphries (Accelerate Diagnostics, USA)
"Diagnostics for Single Pathogen Drugs"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Jason Rosch (St. Jude Children's Research Hospital, USA)
"Emergence of Antibiotic Resistance in the Immune-Compromised"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Julian Hurdle (Texas A&M Health Science Center, USA)
"Clostridium difficile Infection: Drug Resistance Concerns Mandate the Need for Targeted Therapeutics"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Helen Zgurskaya (University of Oklahoma, USA)
"Kinetic and Molecular Determinants of Antibiotic Permeation Barriers"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Joe Thomas (The Pew Charitable Trusts, USA)
"SPARK: Pew's Shared Platform for Antibiotic Research and Knowledge"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Patricia Bradford (Antimicrobial Development Specialists, LLC, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Twenty First Century Natural Product-Based Antibiotic Discovery
Discussion Leader: Lynn Silver (LL Silver Consulting, LLC, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Bradley Moore (University of California, San Diego, USA)
"Mining Genomes for Antibiotics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Lucy Foulston (Warp Drive Bio, USA)
"Harnessing Genomic Information to Engineer the Biosynthesis of Novel Antibiotics with Novel MOA"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Gerry Wright (McMaster University, Canada)
"Molecular Phylogentics to Guide New Natural Product Discovery"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
John Chu (The Rockefeller University, USA)
"Bioinformatics and Chemistry Join Forces for Antibiotics Discovery"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Gram-Negative Outer Membrane Biogenesis – Targeting Antibiotic Barrier
Discussion Leader: Alita Miller (Entasis Therapeutics, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Daniel Kahne (Harvard University, USA)
"Characterizing the Machine that Builds the Outer Membrane"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Natividad Ruiz (Ohio State University, USA)
"Understanding LPS Transport"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Maofu Liao (Harvard Medical School, USA)
"High Resolution Views of Lipopolysaccharide Transport Revealed by Cryo-EM"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
Anna Konovalova (University of Texas Health Science Center at Houston, USA)
"Chemical Inhibitor of an Essential Stress Response Pathway"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Ryan Cirz (Achaogen, Inc., USA)
"Widening the Therapeutic Window of LpxC Inhibitors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mary Alexander (Genentech, USA)
"Inhibition of the LPS ABC Transporter MsbA as a Novel Antibacterial Strategy for Gram-Negative Pathogens"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Re-Examining Chemical Design Strategies for Antibacterial Agents
Discussion Leader: Heinz Moser (Novartis Institutes for Biomedical Research, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Paul Hergenrother (University of Illinois at Urbana-Champaign, USA)
"Predictive Guidelines for Compound Accumulation Lead to New Broad-Spectrum Antibiotics"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Peter Tonge (Stony Brook University, USA)
"Drug-Target Kinetics and Antibacterial Efficacy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Thomas Durand-Reville (Entasis Therapeutics, USA)
"The Rational Design and Discovery of ETX2514, a Novel Broad Spectrum Inhibitor of Class A, C and D β-Lactamases"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Alastair Parkes (Evotec (UK) Ltd, United Kingdom)
"Hybrid Antibacterials: A Strategy to Improve Potency and Spectrum"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Antibacterial Agents and Alternative Approaches
Discussion Leader: Heike Broetz-Oesterhelt (University of Tübingen, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Peter Smith (Genentech, USA)
"Optimized Arylomycins Are a New Class of Gram-Negative Antibiotics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Cuong Vuong (AiCuris Anti-Infective Cures GmbH, Germany)
"Bottromycin - Inhibition of Protein Synthesis by a New Binding Mode"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Erik Boettger (University of Zurich, Switzerland)
"Development of Next Generation Aminoglycosides with Activity Against Multidrug-Resistant Pathogens"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Deborah Hung (Broad Institute / Harvard Medical School / Massachusetts General Hospital, USA)
"Systems Chemical Biology Approach to Antibiotic Discovery?"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Shahriar Mobashery (University of Notre Dame, USA)
"Targeting Clostridium difficile with Novel Classes of Antibiotics"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Marius Spohn (Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Germany)
"Exploiting Termite Nest Microbiomes for Antibiotic Discovery"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Craig MacNair (McMaster University, Canada)
"Overcoming mcr -1 Mediated Colistin Resistance with Colistin in Combination with Other Antibiotics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Antibacterial Agents for Difficult to Eradicate Infections
Discussion Leader: Aileen Rubio (Spero Therapeutics, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Clifton Barry (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Lessons from Oxazolidinones for Tuberculosis Treatment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Raymond Schuch (ContraFect Corporation, USA)
"Lysin CF-301: A Potent Anti-Staphylococcal Biofilm Agent"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Anu Arya (Arietis, USA)
"Development of Ureadepsipeptides to Treat Difficult to Eradicate Infections"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
David Roper (University of Warwick, United Kingdom)
"Antibiotic Inhibition of D-Ala:D-Ala Ligase Through a Novel Phosphoryl Intermediate"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Therapeutic Candidates in the Clinical Development Pipeline
Discussion Leader: George Drusano (University of Florida, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Jennifer Leeds (Novartis Institutes for BioMedical Research, USA)
"LYS228, a Novel Monobactam to Treat Infections Caused by Multi-Drug Resistant Enterobacteriaceae"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Lynn Connolly (Achaogen, USA)
"The Plazomicin Development Program: Lessons Learned from Running Resistant Pathogen Focused Trials"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Troy Lister (Spero Therapeutics, USA)
"Potentiation as an Approach to Gram-Negative Anti-Infective Drug Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Mike Gordeev (MicuRx Pharmaceuticals, Inc., USA)
"Anti-Gram-Negative Agent MRX-8: Innovative Polymyxin with Improved Class Safety"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
V. Balasubramanian (BUGWORKS Research Inc., India)
"Novel Dual Target Bacterial Replication Inhibitors with Extensive Broad Spectrum Activity"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Joe Newman (Tetraphase Pharmaceuticals, USA)
"TP-6076: Novel Fluorocycline Antibiotic with Potent Activity Against Carbapenem-Resistant Gram-Negative Isolates"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Antibacterial Drug Discovery and Development in the Next Decade
Discussion Leader: Laura Piddock (University of Birmingham, United Kingdom / Global Antibiotic R&D Partnership (GARDP), Switzerland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Steven Projan (MedImmune / AstraZeneca, USA)
"Pathogen Specific Biologic Drugs as Antibacterial Agents: Emil von Behring vs. Sir Alexander Fleming"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Michael Dudley (The Medicines Company, USA)
"Success vs. Failure, and Punishing Good Deeds: Hard Questions for Innovation in Infectious Diseases"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
John Rex (Rex Life Sciences LLC, USA)
"Predictions Are Difficult, Especially When They Are About the Future – So What Should You Consider as You Place Your Bets for the Future"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure