Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Antibiotic Resistance and the Need for Novel Antibiotic Therapies
Discussion Leader: Heike Broetz-Oesterhelt (University of Tübingen, Germany)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
George Zhanel (University of Manitoba, Canada)
"Multi-Drug Resistant (MDR) Pathogens Are Driving The Need for New Novel Antibacterials"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Laura Piddock (Global Antibiotic R&D Partnership (GARDP), Switzerland)
"GARDP: Working Globally to Address the Antimicrobial Resistance Crisis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
David Weiss (Emory Antibiotic Resistance Center, United States)
"How Heteroresistance Changes our Understanding of Antibiotic Resistance"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Approaches to Antibiotic Discovery
Discussion Leader: Gerry Wright (McMaster University, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Kim Lewis (Northeastern University, United States)
"Reviving Natural Products Antibiotic Discovery"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Jonathan Stokes (McMaster University, Canada)
"Generative Artificial Intelligence for Antibiotic Discovery"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Cesar de la Fuente (University of Pennsylvania, United States)
"AI for Antibiotic Discovery"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Deborah Hung (Harvard Medical School and Massachusetts General Hospital, United States)
"Systems Chemical Biology Approach to Antibiotic Discovery"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Dr. Gaynor Watson-Creed (Dalhousie University Faculty of Medicine, Canada)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Targets to Drugs in Antibiotic Discovery
Discussion Leader: Kim Lewis (Northeastern University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Oliver Zerbe (University of Zurich, Switzerland)
"Macrocyclic Peptides Disassemble the Periplasmic LPS Transport Bridge: New Approaches to Kill Multidrug-Resistant Gram-Negative Bacteria"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Markus Weingarth (Utrecht University, The Netherlands)
"Cracking Nature’s Recipes to Design Lipid-Targeting Antibiotics"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Late-Breaking Topic
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
From Hits to Leads to Candidates
Discussion Leader: Ryan Cirz (Revagenix, Inc., United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Yossef Av-Gay (University of British Columbia, Canada)
"Achilles Heel of the Trojan Horse; Host Directed Therapy Against Mycobacterial Infections"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Holly Sutterlin (Prokaryotics Inc., United States)
"Discovering Mechanistically Novel Antibacterial Leads Through Phenotypic Screening"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Andrew Tomaras (Blacksmith Medicines, United States)
"Attracting new Anti-infective Candidates with Novel Targets Using the MAGNET Discovery Platform"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Chad Testa (Curza, United States)
"Engineering Broad Spectrum Novel Ribosome Inhibitors"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Shahul Hameed P (Bugworks Research Inc, India)
"Discovery of BWC0977: A Novel Bacterial Topoisomerase Inhibitor (NBTI) as a Broad-Spectrum Antibacterial Clinical Candidate with Potential to Treat Critical Care Infections"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Bacterial Cell Envelope: Targets and Requirements for Drug Permeation
Discussion Leader: Paul Hergenrother (University of Illinois at Urbana-Champaign, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Andrew Edwards (Imperial College London, United Kingdom)
"How do Polymyxins Kill Bacteria?"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Steven Rutherford (Genentech, United States)
"Measuring the Interactions of Polymyxins with the Gram-Negative Outer Membrane"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Karanbir Pahil (GSK, United States)
"A new Antibiotic Traps Lipopolysaccharide in its Intermembrane Transporter"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Antibiotic Combination Therapy
Discussion Leader: Robert Bonomo (Cleveland VA Case Western Reserve University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Olga Lomovskaya (Qpex Biopharma, United States)
"Beta-lactamases and Skaters: Pairs and Singles"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Lori Burrows (McMaster University, Canada)
"How to Give Bacteria Food Poisoning: Antibiotics that Hijack Nutrient Transporters"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Khalid M. Dousa (Assistant Professor, Case Western Reserve University, United States)
"Mycobacterium abscessus: The Promise of Dual ß-Lactams Therapy"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Jürgen Bulitta (University of Florida, United States)
"Mechanistic Insights and Therapeutic Strategies for Targeting the Most Synergistic Penicillin-Binding Proteins Across Three Gram-Negative ‘Superbugs’"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Maneesh Paul Satyaseela (Orchid Pharma, Microvioma, India)
"The journey for the Discovery of Enmetazobactam"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unconventional Antibiotics. Phage Therapy and Anti-infectives
Discussion Leader: Eric Brown (McMaster University, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Matthew Schaefers (Boston Children's Hospital, United States)
"Activation of a Signaling Pathway to Inhibit Bacterial Virulence"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Alexander Hynes (McMaster University, Canada)
"Biasing Bacteriophage Behaviours"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Gail Stanley (Yale University, United States)
"Tentative: Clinical Data on a Phage Trial"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Moving the Needle for Difficult-to-Eradicate Infections
Discussion Leader: Richard Lee (St. Jude Children's Research Hospital, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Julian Hurdle (Texas A&M Health Science Center, United States)
"Addressing Antimicrobial Resistance in Clostridioides difficile : Clinical Implications and the Motivation for Novel Treatment Approaches"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Vasan Sambandamurthy (Bugworks Research India Private Limited, India)
"A Six Decade Wait for a Novel Broad-spectrum Antibacterial Drug Class – Development of BWC0977"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Thomas Dick (Hackensack Meridian Health, United States)
"Redesign of Rifamycins for the Treatment of Mycobacterium Abscesuss Lung Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Lynn Connolly (AN2 Therapeutics, United States)
"Epetraborole: A New Option in the Antimicrobial Arsenal for NTM Treatment"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Sven Hobbie (University of Zurich, Switzerland)
"Apramycin, a Promising Candidate in the Treatment of Chronic NTM Infections"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Learning from Failures and Moving to Success in Clinical Trials
Discussion Leader: Vasan Sambandamurthy (Bugworks Research India Private Limited, India)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Subasree Srinivasan (GARDP, United States)
"Designing and Executing Clinical Trials for Success: Case Study on Developing Targeted Antibiotics"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
William Stubbings (F. Hoffmann-La Roche Ltd.,, Switzerland)
"Experiences and Learnings through Developing a Novel Antibiotic, Zosurabalpin"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Ursula Theuretzbacher (Center for Anti-Infective Agents, Austria)
"Integrating Global Needs and R&D Activities to Solve the Antibiotic Resistance Crisis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure