Saturday |
1:30 pm - 4:30 pm | Arrival and Check-in |
3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:15 pm - 4:00 pm | How
to Qualify a Drug Candidate for Development |
| Discussion Leader: Matthew Surdel (Vanderbilt University, USA) |
3:15 pm - 3:50 pm | Lynn Silver (LL Silver Consulting, LLC, USA) "How to Qualify a Drug Candidate for Development" |
3:50 pm - 4:00 pm | Discussion |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Early
Discovery and Mechanism of Action Studies |
| Discussion Leaders: Linda Oyama (Aberystwyth University, United Kingdom) and Marina Santiago (Harvard University, USA) |
5:30 pm - 5:45 pm | Renee Bouley (University of Notre Dame, USA) "Exploration of the Mechanism of Action and Structure-Activity Relationship for a New Class of Quinazolinone Antibiotics" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:05 pm | Jennifer Stepanek (Ruhr-University Bochum, Germany) "Dual Mechanism of Action of the Atypical Tetracycline Chelocardin" |
6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:25 pm | Michaela Wenzel (University of Amsterdam, The Netherlands) "Reorganization of Fluid Lipid Domains by Daptomycin Inhibits Bacterial Cell Wall Synthesis" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:45 pm | Ashleigh Paparella (The University of Adelaide, Australia) "Template Guided Synthesis Provides New Antibacterials and Antifungals" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:05 pm | Andrew Lim (University of Dundee, United Kingdom) "Mug the Bug: Applying Phenotypic Screening and Metabolomics in the Search for Novel Antibacterials" |
7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Bradley Poulsen (Massachussetts General Hospital / Broad Institute, Harvard Medical School, USA) "A Multiplexed Chemical Screen of Pseudomonas aeruginosa Hypomorphs Rapidly Identifies Novel Antibiotic Leads" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Sunday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Achieving,
Maintaining, and Restoring Compound Efficacy |
| Discussion Leader: Philip Bulterys (University of California, Los Angeles, USA) |
9:00 am - 9:45 am | Ursula Theuretzbacher (Center for Anti-Infective Agents, Austria) "Understanding PK/PD in Early Antibiotic R&D" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Bimal Jana (University of Copenhagen, Denmark) "Gene-Antimicrobial Drug Interactome of MDR Klebsiella pneumoniae ST258" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Giulia Orazi (Geisel School of Medicine, Dartmouth College, USA) "Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection" |
10:35 am - 10:40 am | Discussion |
10:40 am - 10:55 am | Ryan Lamers (McMaster University, Canada) "Reversing Beta-Lactam Resistance in Pseudomonas aeruginosa: A High-Throughput Screen for Inhibitors of Peptidoglycan Recycling" |
10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Mentorship Component: Insights from the Industry |
| Discussion Leader: Miranda Jarrett (St. Jude Children's Research Hospital, USA) |
1:30 pm - 2:30 pm | Panel Discussion |
| "Lessons Learned from a Career in Drug Discovery and Development" |
|
- Michael Dudley (The Medicines Company, USA)
- Lynn Silver (LL Silver Consulting, LLC, USA)
|
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |