Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Antibacterial Drug Discovery: Perspectives from Industry
Discussion Leader: Alen Krajnc (University of Ljubljana, Slovenia)
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:50 pm
Scott Hecker (Qpex Biopharma, United States)
"Discovery and Development of Antibacterial Agents: Vaborbactam Case Study"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Alternative Approaches for Discovering Antibacterials from Gram-Positive and Gram-Negative Bacterial Threats
Discussion Leader: Renee Fleeman (The University of Central Florida, United States)
5:30 pm - 5:45 pm
Geetika Dhanda (Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), India)
"Small Molecular Adjuvants: Resistance Breakers That Revitalize Obsolete Antibiotics Against Gram-Negative Superbugs!"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Neha Prasad (University of California, San Francisco, United States)
"A Pooled CRISPRi Screen to Probe Pseudomonas aeruginosa Gene Vulnerability in a Murine Pneumonia Model"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Archit Vasan (University of Illinois at Urbana-Champaign, United States)
"Investigating Molecular Mechanisms of Antibiotic Permeation through Outer Membrane Porins"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Rebecca Ulrich (University of Illinois at Urbana-Champaign, United States)
"Exploring the Physicochemical Properties Governing Compound Efflux in Gram-Negative Bacteria"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Kenneth Rachwalski (McMaster University, Canada)
"Using a Transcriptional Reporter to Identify Antimicrobial Compounds that Target the Bacterial Cell Envelope"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Petra Szili (Biological Research Centre, Hungary)
"Rational Design of Balanced Dual-Targeting Antibiotics with Limited Resistance"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Development of New Antibacterials with Novel Targets and New Mechanisms of Action
Discussion Leader: Tomayo Berida (University of Mississippi, Oxford Mississippi, United States)
9:00 am - 9:30 am
Heike Broetz-Oesterhelt (University of Tübingen, Germany)
"Keynote: Mechanism of Action Studies of Natural Product Antibacterials"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Lindsey Carfrae (McMaster University, Canada)
"Inhibiting Fatt Acid Biosynthesis Reverses Colistin Resistance in mcr-1 Expressing Enterobacteriaceae "
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Victoria (Tori) Klein (National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States)
"Elucidating the Mechanism of Action of Marine-Derived Antibiotic Adjuvants from a Class of Pyrrole-Imidazole Alkaloids"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Melissa Vázquez Hernández (Ruhr Universität Bochum, Germany)
"Dual Mechanism Antimicrobial Agents – Trans -Translation Inhibition Synergizes With Copper Toxicity"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Chandradhish Ghosh (Institute for Molecular Infection Biology, Germany)
"My Quest for Alternatives to Antibiotics: From Membrane-Active Agents to Antisense Therapy"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Panel Discussion: Leading Researchers in Academia and Industry
Discussion Leaders: Victoria Coles (McMaster University, Canada)
1:30 pm - 2:30 pm
Panel Discussion
Leading Researchers in Academia and Industry
Heike Broetz-Oesterhelt (University of Tübingen, Germany)
Scott Hecker (Qpex Biopharma, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes