| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and William C. Sessa (Yale University) |
| 7:40 pm - 9:30 pm | KEYNOTE LECTURES |
| Discussion Leader: Steven S. Gross (Cornell University Medical School) |
| 7:40 pm - 8:25 pm | Salvador Moncada (University College London)
"Role of NO in mitochondrial function" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Bettie Sue Masters (University of Texas Health Sciences, San Antonio)
"Perspectives in NOS enzymology from insights derived from P450" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NO GENERATING/SENSING PATHWAYS: STRUCTURE AND FUNCTION |
| Discussion Leader: Brian Crane (Cornell University) |
| 9:00 am - 9:25 am | Elizabeth D. Getzoff (The Scripps Research Institute)
"Structural insights into NOS function" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | William R. Montfort (University of Arizona)
"Nitrophorins as NO transport proteins" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break / Group Photo |
| 11:10 am - 11:35 am | Dennis Stuehr (Cleveland Clinic Foundation)
"Mechanisms of NOS catalysis" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Focco van den Akker (Case Western Reserve University)
"Insights into NO activation of the soluble guanylyl cyclase" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IN VIVO CHEMISTRY AND ACTIONS OF NO: NO ADDUCTS OR CGMP SIGNALING |
| Discussion Leader: Charles Lowenstein (The Johns Hopkins Hospital) |
| 7:30 pm - 7:55 pm | Mark Gladwin (National Institute of Health)
"Nitrite regulation of regional blood flow control" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Joan Mannick (University of Massachusetts Medical School)
"S-nitrosylation and ALS" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Doris Koesling (Ruhr-Universitat Bochum)
"Physiological roles of NO-cGMP-PKA pathways in vivo" |
| 9:15 pm - 9:30 | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | UNCOUPLED NOS: IS IT REAL IN VIVO? MECHANISMS AND PATHOPHYSIOLOGY |
| Discussion Leader: Kirk Pritchard (Medical College of Wisconsin) |
| 9:00 am - 9:25 am | Antonius Gorren (Karl-Franzen - Universitat Graz)
"Biochemistry of uncoupled NOS: Truth and fiction" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Jay Zweier (The Ohio State University)
"Detection and generation of superoxide from NOS" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 | Coffee Break |
| 11:10 am - 11:35 am | Ingrid Flemming (Klinikum der J.W. Goethe-Universitat)
"Regulation of eNOS function" |
| 11:35 am - 11:50 am | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELLULAR BIOLOGY OF NO AND NOS |
| Discussion Leader: David Fulton (Medical College of Georgia) |
| 7:30 pm - 7:55 pm | Tim Billiar (University of Pittsburgh)
"TBA" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | N Tony Eissa (Baylor College of Medicine)
"Post-translational control of iNOS" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Charles Lowenstein (The Johns Hopkins Hospital)
"NO regulation of secretion" |
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TERMINATION OF NO SIGNALING |
| Discussion Leader: Ferid Murad (University of Texas - Houston Medical School) |
| 9:00 am - 9:25 am | Harry Ischiropoulos (University of Pennsylvania)
"Redox regulation of NO bioactivity" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Limin Liu (University of California, San Francisco)
"Physiological control of SNO activity by SNO reductase" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:40 am - 11:05 am | Sharron Francis (Vanderbilt University School of Medicine)
"cGMP phosphodiesterase control of NO signaling" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 12:30 pm | HOT TOPICS SESSION (YOUNG INVESTIGATORS AWARDS) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 8:10 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:10 pm - 9:10 pm | Alexander Varshavsky (California Institute of Technology)
"NO and regulated protein degradation" |
| 9:10 pm - 9:25 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ROLES OF NO IN PHYSIOLOGY AND PATHOPHYSIOLOGY |
| Discussion Leader: Gabor M. Rubanyi (Cardium Therapeutics, Inc.) |
| 9:00 am - 9:25 am | Manasi Nandi (University Colllege London)
"Regulation of ADMA in Health and disease" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | James G. Tidball (University of California, Los Angeles)
"nNOS correction of cardiomyopathy" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 11:10 am - 11:35 am | David Roberts (National Institute of Health)
"Reciprocal control of angiogenesis by NO and thrombospondins" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Kenneth Bloch (Massachusetts General Hospital)
"Role of NO in models of heart disease" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THERAPEUTIC STRATEGIES AIMED AT REGULATING NO BIOLOGY |
| Discussion Leader: William C. Sessa (Yale University) |
| 7:30 pm - 7:55 pm | Vijay Shah (Mayo Clinic)
"Manipulation of NO in liver disease" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Warren Zapol (Massachusetts General Hospital)
"Inhaled NO as a Therapeutic" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Jane R. Connor (Pfizer)
"Role of NO in arthritis" |
| 9:15 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
