Gordon Research Conference on “Nitric Oxide (NO)” is designed to provide chemists, biologists, cell biologists, clinicians and other scientists with state of the art knowledge on the basic structure/function relationships of NO generating systems and the biology of NO as a signaling molecule in physiological and pathophysiological states. Sessions will include the chemical and molecular mechanism of action of nitric oxide in cardiovascular and neurodegenerative diseases as well as cancer. Specific sessions will focus on basic chemistry and biochemistry with emphasis on the mechanisms of NO action at various levels of NO and its role in cardiovascular, neurodegenerative disease and cancer. In addition, there are two prominently featured poster sessions selected from abstracts submitted to the meeting and a special "hot topics" session that encourages last minute submissions of exciting findings from new or established investigators culminating in awards for outstanding junior investigators. The main strength of this meeting is the opportunity for cross disciplinary interactions in a highly focused, yet informal intellectually stimulating atmosphere. The Gordon Conference on NO plays an essential role in exploring new vistas in this important translational field.