Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | NO/NOS in the Central Nervous System |
| Discussion Leader: Joseph Beckman (Oregon State University, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 8:15 pm | Valina Dawson (Johns Hopkins University School of Medicine, USA) "AMPA Receptor Surface Expression is Regulated by S-Nitrosylation of Thorase" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Stuart Lipton (Sanford-Burnham Medical Research Institute, USA) "CNS and S-Nitrosylation" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Monday |
8:30 am | Group Photo |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nitric Oxide Synthases / sGC Structure-Function |
| Discussion Leaders: Dennis Stuehr (Cleveland Clinic, USA) and William Sessa (Yale University, USA) |
9:00 am - 9:30 am | Linda Roman (University of Texas Health Science Center, San Antonio, USA) "NO Control: Nitric Oxide Synthase in Skeletal Muscle" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Elsa Garcin (University of Maryland, Baltimore County, USA) "Regulation of Soluble Guanylate Cyclase Activity by Protein Interactions" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Dennis Stuehr (Cleveland Clinic, USA) "The NO-sGC-hsp90 Nexus" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | C. S. Raman (University of Maryland, USA) "Visualizing the Reaction Dynamics of a NO Sensor at Atomic Resolution" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NO and GSNOR |
| Discussion Leader: Andrew Gow (Rutgers University, USA) |
7:30 pm - 8:00 pm | Limin Liu (University of California, San Francisco, USA) "Regulation of Protein S-Nitrosylation and Protection Against Carcinogenesis by S-Nitrosoglutathione Reductase" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Wolfram Goessling (Dana-Farber Cancer Institute, USA) "GSNOR Biology" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Moran Benhar (Technion, Israel) "Redox Regulation Through S-Nitrosylation" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nitric Oxide/NOS Interaction with H2S and NOX |
| Discussion Leaders: Bruce Freeman (University of Pittsburgh, USA) and Christopher Kevil (Lousiana State University, USA) |
9:00 am - 9:30 am | Ruma Banerjee (University of Michigan, USA) "Hydrogen Sulfide Oxidation and Reaction Sulfur Species" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Amrita Ahluwalia (Queen Mary University of London, United Kingdom) "Dietary Nitrate and Atherosclerosis" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Csaba Szabo (University of Texas Medical Branch, Galveston, USA) "Cooperative Interactions of H2S and NO Signalling in the Control of Vascular Tone and Angiogenesis" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Martin Feelisch (Southampton University, United Kingdom) "What 'Gasotransmitter'? The Chemistry that Underpins the NO/Sulfide Cross-Talk" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NO PTM'S and Bioenergetics |
| Discussion Leader: Victor Darley-Usmar (University of Alabama, Birmingham, USA) |
7:30 pm - 8:00 pm | Takaaki Akaike (Tohoku University Graduate School of Medicine, Japan) "Redox-Active Cysteine Polysulfide Modulates NO and Electrophilic Protein Modification" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Neil Hogg (Medical College of Wisconsin, USA) "NO and Bioenergetics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Elizabeth Murphy (National Heart, Lung and Blood Institute, USA) "Signaling by S-Nitros(yl)ation in the Heart" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NO, Arginase, Metabolism and Cardiovascular Biology |
| Discussion Leaders: Eddie Weitzberg (Karolinska Institutet, Sweden) and Mark Gladwin (Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, USA) |
9:00 am - 9:30 am | Paul Huang (Massachusetts General Hospital, USA) "Modulation of NO/eNOS Pathways by Arginases and Effects on Metabolism" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Claudia Morris (Emory University School of Medicine, USA) "An Altered Arginine Metabolome in Hemoglobinopathies" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Karin Potoka (University of Pittsburgh, Vascular Medicine Institute, USA) "Aiming at Sickle Cell Disease with Novel Small Molecules that Target sGC" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Brendan Lee (Baylor College of Medicine, USA) "Arginosuccinate Lyase and Nitric Oxide Production" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late-Breaking Topics / Keynote |
| Discussion Leader: Sruti Shiva (University of Pittsburgh, USA) |
7:30 pm - 7:40 pm | Selected from Poster Abstracts: Miriam Cortese-Krott (Heinrich Heine University of Düsseldorf, Germany) "Purification, Intracellular Signaling and Function of a NO-Sensitive Guanylate Cyclase in Red Blood Cells" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Selected from Poster Abstracts: Todd Milne (Ironwood Pharmaceuticals, USA) "Discovery and Characterization of a Novel Class of sGC Stimulators for the Treatment of Cardiovascular Diseases" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Selected from Poster Abstracts: Justin Percival (University of Miami, Miller School of Medicine, USA) "Deciphering the Potential of cGMP as a Pharmacotherapy for Obesity and Diabetes" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Selected from Poster Abstracts: Antonius C.F. Gorren (Karl-Franzens University Graz, Austria) "Non-Enzymatic Thiol Nitrosation by Submicromolar Nitric Oxide" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Keynote: Michael Marletta (The Scripps Research Institute, USA) "There and Back Again" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NO and Protein PTMs |
| Discussion Leader: Jonathan Stamler (Case Western Reserve University, USA) |
9:00 am - 9:30 am | Alvaro Estevez (University of Central Florida, USA) "Nitrotyrosine a Signaling Post-Translational Modification" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Paul Fox (Cleveland Clinic, USA) "iNOS-S100A8/A9 Nitrosylase Complex Directs Protein S-Nitrosylation by Primary Sequence Motif Recognition" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Dario Vitturi (University of Pittsburgh, USA) "Origin and Fate of Nitrated Fatty Acids in Biology: From Test Tube, to Mice, to Humans" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Steven Tannenbaum (Massachusetts Institute of Technology, USA) "SNOTRAP: A New Tool for the Analysis of S-Nitrosated Peptides and Proteins by Mass Spectrometry and Imaging" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NO and GNOR Biology |
| Discussion Leader: Jon Lundberg (Karolinska Institutet, Sweden) |
7:30 pm - 8:00 pm | Joshua Mattila (University of Pittsburgh, USA) "Nitric Oxide Synthase Expression in Cynomolgus Macaques with Pulmonary Tuberculosis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Andres Vazquez-Torres (University of Colorado, Denver, USA) "Adaptive Transcriptional Responses to NO-Mediated Metabolic Stress" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ferric Fang (University of Washington, USA) "Antimicrobial Actions of Nitric Oxide" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |