Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Heme and Nitric Oxide
Discussion Leader: Jonathan Stamler (Case Western Reserve University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:45 pm
Dennis Stuehr (Cleveland Clinic, United States)
"From Heme to Nitric Oxide and Back Again: Remarkable Relationships and Their Astounding Consequences"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Kyle Lancaster (Cornell University, United States)
"Heme P460: It's NO P450"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cardiovascular Function: The Role of Nitric Oxide in Physical Performance and Health
Discussion Leaders: Jason Allen (Universtiy of Virginia, United States) and Anni Vanhatalo (University of Exeter, United Kingdom)
9:00 am - 9:20 am
Chris Easton (University of the West of Scotland, United Kingdom)
"Nitric Oxide Effect? The Intra- and Interindividual Variability in the Response to Dietary Nitrate Supplementation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Simone Porcelli (University of Pavia, Italy)
"Changes in Nitric Oxide Metabolism with Exercise Training: Do We Really Need More at Skeletal Muscle Level?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Nathan Bryan (Nitric Oxide Innovations, LLC, United States)
"Bridging the Gap: Translation of Nitric Oxide Discoveries Into Clinical Medicine"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
Hans Ackerman (National Institute of Allergy and Infectious Diseases, NIH, United States)
"Human Arterial Vasoreactivity is Modulated by Variation in The Abundance and Structure of Endothelial Hemoglobin"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Gianmichele Massimo (Queen Mary University of London, United Kingdom)
"Natural mutations of human XDH promote the nitrite-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Taiming Liu (Loma Linda University, United States)
"A nitrodilator-activated intracellular NO store (NANOS) important for cardiovascular health"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Miriam Cortese-Krott (Heinrich Heine University Düsseldorf, Germany) and Amrita Ahluwalia (Queen Mary University of London, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cysteine Modification
Discussion Leaders: Annie Beuve (New Jersey Medical School, Rutgers University, United States) and Hozumi Motohashi (Tohoku University, Japan)
7:30 pm - 7:55 pm
Ben Gaston (Indiana University School of Medicine, United States)
"S-nitrosocysteine and Respiratory Control"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Paschalis-Thomas Doulias (University of Ioannina, Greece)
"Protein S-Nitrosylation: From Methodology to Biology and Function"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Hozumi Motohashi (Tohoku University, Japan)
"Nrf2 as a Regulator of Mitochondrial Activity, NO Signaling and Sulfur Metabolism"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Guenter Schwarz (University of Cologne, Germany)
"Regulation of GABAergic Synapses by Gephyrin S-Nitrosylation"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sources of Nitric Oxide Bioactivity and The Role of Redox in Their Regulation
Discussion Leaders: David Wink (National Cancer Institute, NIH, United States) and Ingrid Fleming (Goethe University Frankfurt, Germany)
9:00 am - 9:20 am
Mattias Carlstrom (Karolinska Institutet, Sweden)
"Red Blood Cells from eNOS-Deficient Mice and Patients with Preeclampsia Induce Endothelial Dysfunction via Oxidative Stress and Abnormal Arginase Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Takaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Nitric Oxide Synthases, a New Family of NADPH-Dependent Sulfur Oxidoreductases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Adam Straub (University of Pittsburgh, United States)
"Redox Regulation of sGC by CYB5R3"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
Ji Won Park (Molecular Medicine Branch, NIDDK, NIH, United States)
"Nitric Oxide Metabolism in the Eye: the Importance of Nitrate Reduction Pathways"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Christopher Switzer (Queen Mary University of London, United Kingdom)
"Epigenetic Alterations Induced by Reactive Nitrogen and Sulfur Species"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Laxman Poudel (Wake Forest University, United States)
"Thiol Facilitated Reductive Nitrosylation of Free Heme in a Membrane System"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling Mechanisms of Nitric Oxide and Other Oxidants
Discussion Leaders: Martin Feelisch (University of Southampton, United Kingdom) and Katrina Miranda (University of Arizona, United States)
7:30 pm - 7:50 pm
Miriam Cortese-Krott (Heinrich Heine University Düsseldorf, Germany)
"The Redox Physiology of Red Blood Cells: Lessons from Erythroid Cell-Specific Knock-out and Knock-in Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Melanie Madhani (University of Birmingham, United Kingdom)
"Nitrite and Persulfides in Cardiovascular Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Annie Beuve (New Jersey Medical School, Rutgers University, United States)
"Soluble Guanylyl Cyclase Uses Thioredoxin as a Nitrosothiol Relay: A Marriage of Reason?"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Anthony DeMartino (University of Maryland School of Medicine, United States)
"Thiol Facilitated Reductive Nitrosylation Reaction of Nitric Oxide and Ferric Heme Form A Labile Iron-Nitrosyl-Heme and Thiyl Radical"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Tristan Lewis (Case Western Reserve University School of Medicine, United States)
"S-Nitrosocysteine Behaves as a Hypoxia-Mimetic, cGMP-Independent Ligand, Signaling Through Kvß2"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of Nitric Oxide in Pregnancy and Development
Discussion Leaders: Sharon Glynn (University of Galway, Ireland) and Sruti Shiva (University of Pittsburgh, United States)
9:00 am - 9:20 am
Shathiyah Kulandavelu (Interdisciplinary Stem Cell Institute, University of Miami, United States)
"Role of S-nitrosylation and S-nitrosogluathione Reductase (GSNOR) in Mouse and Human Pregnancy."
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Phoebe Stapleton (Rutgers University, United States)
"Uterine Vascular Reliance on Nitric Oxide During Pregnancy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Thea Golden (University of Pennsylvania, United States)
"Mechanisms of Placental Dysfunction"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
Paola Corti (University of Maryland School of Medicine, United States)
"Cytoglobin Regulates Nitric Oxide-Dependent Cilia Motility and Organ Laterality in Development"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Mauricio Lillo (Rutgers University, United States)
"Connexin 43 Hemichannels and Calcium Entry in Arterial Relaxation in Female Mice"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Veronica Demicheli (Departamento de Bioquimica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay, Uruguay)
"Lysine Acetylation in human MnSOD May Rotect From Tyrosine-34 Nitration and Enzyme Inactivation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunometabolism and Cellular Phenotype
Discussion Leaders: Bruce Freeman (University of Pittsburgh, United States) and Sarah Ewald (University of Virginia, United States)
7:30 pm - 7:55 pm
Mark Crabtree (University of Surrey, United Kingdom)
"Regulation of Macrophage-derived Itaconate by Nitric Oxide: Insights from Cell and Mouse Models of BH4 and NO Deficiency"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Erika Palmieri (National Cancer Institute at Frederick, NIH, United States)
"Nitric Oxide in Macrophage Immunometabolism: Evidence for HNO-mediated Inhibition of Pyruvate Dehydrogenase"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Jenny Chang (Houston Methodist Hospital, United States)
"Dissecting The Synergistic Effects of Nitric Oxide Synthase and PI3K Inhibitors in Metaplastic Breast Cancer"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cardiopulmonary Effects of Nitric Oxide
Discussion Leaders: Amrita Ahluwalia (Queen Mary University of London, United Kingdom) and Debra Laskin (Rutgers University, United States)
9:00 am - 9:20 am
Lorenzo Berra (Massachusetts General Hospital, United States)
"High Dose Inhaled Nitric Oxide: A Very Preliminary Clinical Experience"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stacy Wendell (University of Pittsburgh, United States)
"Nitro-fatty Acid Regulation of Host and Microbial Signaling in Obesity-Associated Asthma"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Thomas Raffay (Case Western Reserve University, United States)
"S-Nitrosoglutathione Reductase: A New Target for Therapeutic Development in Bronchopulmonary Dysplasia"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Serpil Erzurum (Cleveland Clinic, United States)
"Asthma and Nitric Oxide and Inflammation with Arginine Metabolism"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Mamta Sumi (Cleveland clinic foundation, United States)
"Impact of Low NO level on Globin Maturation and Functional Significance of Hemoglobin Resident in The Lung Epithelium"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Zohreh Safari (University of Maryland School of Medicine, United States)
"Oxygen Responsive Metabolic Regulation In Red Blood Cells Via ENOS Based S-nitrosylation Signaling"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Ramesh Chennupati (Universitätsklinikum Düsseldorf, Germany)
"Chronic anemia aggravates the systemic endothelial dysfunction in acute myocardial infarction"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Tomas Schiffer (Karolinska Institutet, Sweden)
"Dimethyl Malonate Preserves Kidney and Mitochondrial Function in A Mouse Model of Acute Kidney Injury"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Sophia Heuser (Heinrich-Heine-University, Germany)
"Erythroid Specific Knock Out of Soluble Guanylyl Cyclase Leads to Disrupted Erythropoiesis, Anemia and Splenomegaly in Mice"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Nitric Oxide Signaling in Vascular Health
Discussion Leader: Lou Ignarro (UCLA Professor Emeritus, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Jon Lundberg (Karolinska Institutet, Sweden)
"Red cells, Hypoxia and Cardioprotection"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Brant Isakson (University of Virginia School of Medicine, United States)
"Emerging Roles for Alpha Globin in the Cardiovascular System"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure