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Nitric Oxide

Gordon Research Conference

Nitric Oxide and Sulfide in Redox Signaling and Medicine

February 9 - 14, 2025

Chair

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Nitric Oxide GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2025 Gordon Research Conference (GRC) on Nitric Oxide marks a significant milestone, celebrating 30 years of groundbreaking research and collaborative scientific exchange. This special anniversary edition, themed "NO and Sulfide in Redox Signaling and Medicine," is designed to highlight cutting-edge advancements in the nitric oxide (NO) field, its interaction with the newly born sulfide field, and how these molecules continue to push the boundaries of science and medicine. This conference is designed to provide a unique opportunity for scientists from diverse fields and at diverse stage of their career to share unpublished findings, discuss novel opportunities, and foster collaborations, thereby advancing our understanding and application of NO and sulfide in health and disease. Invited speakers include experts in chemistry, physiology, pharmacology, and redox medicine.

Related Meeting

This GRC will be held in conjunction with the "Nitric Oxide" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: The Evolving Landscape of Nitric Oxide Research in Redox Signaling and Redox Medicine Discussion Leader:
7:40 pm - 7:55 pm	Introduction by Discussion Leader
7:55 pm - 8:25 pm	"Reactive Sulfur Species Regulation of Cardiometabolic Disease"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 9:10 pm	"Location, Location, Location: What is eNOS Doing in the Nucleus?"
9:10 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Chemistry and Enzymology of Nitric Oxide and Sulfide and their Relevance in the Cellular Environment Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Exploring the Potential of Hydropersulfides (RSSH) to Rescue Deficient Iron-Sulfur Cluster Biosynthesis and Treat Friedreich’s Ataxia"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Molecular Basis for the Scaffolding Activity of Caveolin-1"
9:55 am - 10:05 am	Discussion
10:05 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"New Role for NO in Regulating Cell Heme Allocations and Hemeprotein Activities"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Stimuli Responsive Nitric Oxide Releasing Materials (NORMs) for Cardiovascular Applications"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizers: , and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Translational Studies and Pharmacological Applications Discussion Leaders: and
7:30 pm - 7:50 pm	"Aortic Valve Disease and Systemic Endothelial Function on Nitric Oxide Metabolism"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"New Studies on Heme and Hemoglobin Based NO Signaling"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Human Specific cGMP Regulation: cGMP Measurements in Living Human Cardiomyocytes Reveal New Drug NO-based Targets"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Late-Breaking Topic
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Nitric Oxide and Sulfur Species in Redox Signaling and Cysteine Modification Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Thiol Redox Sensing and Signaling in the Cardiovascular System: Therapeutic Opportunities"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Essential Role of Sulfide Oxidation in Brain Health"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	Late-Breaking Topic
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Aberrant S-Nitrosylation Disrupts TCA Cycle Energy Production in Neurons and thus Contributes to Synapse Loss in Alzheimer’s Disease"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Neuroprotective Actions by Fatty Acid Nitroalkene in Parkinson’s Disease"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Non-Canonical Signaling and Cell-Cell Communication Discussion Leaders: and
7:30 pm - 7:50 pm	"Nitrite Modulates Mitochondrial Dynamics to Attenuate Pathological Vascular Remodeling"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Updating the Biological Chemistry of Peroxynitrite"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Hydrogen Cyanide, an Emerging Novel Mammalian Gaseous Transmitter"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Late-Breaking Topic
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Redox Signaling and Mechanotransduction Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Can You Feel the Force? A New Mode of Mechanosensitive NO-cGMP Signaling in the Cardiovascular System."
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Signaling by Red Blood Cells in Cardiovascular Regulation"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Nitric Oxide and Redox Cross Talk in the Vascular Wall"
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Iron Regulation of Endothelial NO"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Nitrite Reductase Activity of Liver-derived Xanthine Oxidoreductase Maintains Cardiovascular Homeostasis"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Insights of the NO/Sulfide Redox Lanscape: Single Cell Analysis, Interorgan Communication, and Microbiome Discussion Leader:
7:30 pm - 7:50 pm	"Microbiome-derived Hydrogen Sulfide as a Metabolic Trigger for CIMP Colorectal Cancer"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Sulfide Talks, Adipose Tissue Listens"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Late-Breaking Topic
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Late-Breaking Topic
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Integrating Nitric Oxide and Sulfide Research into Clinical Practice Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Exploring High-Dose Inhaled Nitric Oxide as an Innovative Antipseudomonal Treatment"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Novel NO and Heme-Independent sGC Activators: A treatment Approach for Cardiorenal Diseases"
9:55 am - 10:05 am	Discussion
10:05 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Small Molecule Nitroalkene Regulation of Tissue Metabolic and Inflammatory Stress"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Late-Breaking Topic
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Late-Breaking Topic
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Bringing the Nitric Oxide Field into the Future of Redox Medicine Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	"Targeting iNOS for Cancer Treatment: From Basic Science to Clinical Application"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:00 pm	"The Role of NO/cGMP in Energy Homeostasis and Brown Adipose Tissue"
9:00 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

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Conference History Nitric Oxide (GRS)

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